Cerebellar Purkinje cells change dendritic architecture during primate evolution biorxiv.org 2026-06-08 Vertebrate evolution has driven adaptive remodeling of brain regions impacted by changing sensorimotor demands.
Early life adversity is associated with mental health and life histories through short-term mindsets biorxiv.org 2026-06-08 Early life adversity is associated with increased risk for psychopathology and shifts in life history (LH) strategies, but the psychological mechanism
Cross-domain encoding models reveal shared and domain-specific neural representations across language and mathematics biorxiv.org 2026-06-08 Whether language and mathematics rely on shared or distinct neural representations remains an unresolved question in cognitive neuroscience.
A modular neural circuit for computing the motion of objects biorxiv.org 2026-06-08 Computing the direction of a moving object requires integrating motion signals from its component edges into coherent patterns.
Early postnatal DNA methylation dynamics define neuronal subtypes and are disrupted by MECP2 loss biorxiv.org 2026-06-08 DNA methylation is the foundational layer of epigenetic regulation underlying mammalian tissue specification.
Spatial and Molecular Progression of Neural Progenitor Cells in the Developing Human Dentate Gyrus biorxiv.org 2026-06-08 The cellular diversity in the human brain is underpinned by neural progenitor cells(NPCs).
Homophily-informed generative models of brain maps biorxiv.org 2026-06-08 The structural and functional organization of the brain can be studied across multiple scales, yielding richly detailed topographic brain maps of biol
Distinct associations between thalamo-amygdala pathways and state anxiety biorxiv.org 2026-06-08 Neurobiological models of emotion have proposed the existence of multiple direct subcortical pathways in humans, often referred to as "low roads", lin
Sound-evoked orofacial motion only affects a fraction of visually responsive V1 neurons in a multisensory detection task with delayed reward delivery biorxiv.org 2026-06-08 Auditory stimuli have been known to elicit neural responses in visual cortical areas, but such responses are partly associated with sound-evoked orofa
Genome degradation in the c-di-GMP signaling pathways and serovar-specific YhjH-YciG interactions rewired motility regulation in Salmonella Paratyphi A biorxiv.org 2026-06-08 Salmonella enterica serovars Typhimurium (STM) and Paratyphi A (SPA) cause clinically distinct diseases, yet the molecular bases for their different l
The huntingtin-HAP40 complex is a bidirectional cellular rheostat biorxiv.org 2026-06-08 Huntingtin-associated protein 40 (HAP40) is an obligate structural subunit of huntingtin (HTT) and is rapidly degraded when unbound, yet has been cons
Asymmetric introgression and thermal advantage jointly drive climate-mediated lineage turnover in a mixed-ploidy reed biorxiv.org 2026-06-08 Species distribution forecasts commonly overlook intraspecific genetic variation, missing a potentially important mechanism of ecosystem change: clima
Cross Potential Selection for Multiple Traits Considering the Progeny Distribution of Future Inbred Lines in Plant Breeding Programs biorxiv.org 2026-06-08 In plant breeding, it is often necessary to improve a target trait while maintaining other essential traits within desirable ranges.
Genomic Inbreeding and Selection Signatures analyses in the Doberman Pinscher breed biorxiv.org 2026-06-08 The Doberman Pinscher population has undergone strong artificial selection for morphology and behavior, which can reduce genomic diversity and increas
scFAIR Consortium: a decentralized hub for single-cell RNA-Seq data standardization and unification biorxiv.org 2026-06-08 The rapid accumulation of single-cell RNA-Seq (scRNA-seq) data across multiple repositories presents major challenges for data accessibility, integrat
Conformational changes underlying electromechanical transduction in prestin resemble a transport transition in pendrin biorxiv.org 2026-06-08 Prestin (SLC26A5), a membrane protein in cochlear outer hair cells, drives electromechanical transduction essential for mammalian hearing.
MZF1-mediated GAPDH overexpression drives glycolytic reprogramming and neuroendocrine progression in advanced prostate cancer biorxiv.org 2026-06-08 Drug resistance to the androgen receptor (AR) antagonist is a critical obstacle in the clinic for advanced prostate cancers.
Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional Analyses biorxiv.org 2026-06-08 Multiple myeloma (MM) evolves from asymptomatic precursor conditions through progressive genetic and epigenetic remodeling, yet the regulatory mechani
A human lung organoid co-culture model of early bone sarcoma metastasis reveals contact-dependent epithelial remodeling at the metastatic interface biorxiv.org 2026-06-08 Lung metastasis drives mortality across cancer types, yet how infiltrating tumor cells remodel the lung epithelium to establish metastatic niches rema
Tumor-derived FXII engages the intrinsic coagulation cascade to support breast cancer liver metastasis. biorxiv.org 2026-06-08 Metastasis is the leading cause of death in breast cancer, yet the mechanisms controlling organotropism are not well defined.
Biotic versus environmental controls on microbial degradation of permafrost organic matter biorxiv.org 2026-06-08 Permafrost thaw exposes ancient organic matter to microbial degradation, which is predicted to release globally significant quantities of greenhouse g
DNMT mRNA stability and YB-1 cooperatively regulate ABCB1 to drive cisplatin chemoresistance in cholangiocarcinoma biorxiv.org 2026-06-07 Background and Aims: Intrahepatic cholangiocarcinoma (iCCA) is a tumor type with a high lethality due to late diagnosis and profound resistance to con
AKIP1 is an inner scaffold component required for centriole integrity biorxiv.org 2026-06-07 Centrioles are microtubule-based organelles that play crucial roles in various biological processes, including cell division, ciliogenesis and flagell
Identification of highly immunogenic endogenous dsRNAs from cellular MDA5 filaments biorxiv.org 2026-06-07 ADAR1 converts adenosine to inosine in endogenous double-stranded RNAs (dsRNAs) to prevent excessive MDA5-driven interferon-stimulated gene expression
Effects of ERK1/2 Signaling on Cell Cycle Regulation by the Tuberin-Cyclin B1 Complex biorxiv.org 2026-06-07 How cells balance growth (cell size) and division (cell number) requires a complex interplay between response to external signals, including growth fa
Heterochromatin organization and liquid-liquid phase separation: it is not about if but about when biorxiv.org 2026-06-07 Heterochromatin is a membraneless compartment within the cell nucleus.
Copper transport to mitochondria by SLC25A3 contributes to skeletal myoblast differentiation and is required for survival of differentiated myotubes biorxiv.org 2026-06-07 Differentiation of skeletal muscle is associated with increased mitochondrial biogenesis and reliance of oxidative phosphorylation (OXPHOS).
Cell free-mtDNA release drives pyroptosis and inflammation in cell models carrying the mitochondrial m.3243A>G pathogenic variant biorxiv.org 2026-06-07 Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) syndrome is primarily caused by the heteroplasmic m.3243A>G/MT-TL1
A transient epithelial plasticity state defines the developmental window for uterine gland specification biorxiv.org 2026-06-07 Uterine gland development and function is essential for reproduction and womens health, yet the epithelial cell states and signaling interactions that
Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy biorxiv.org 2026-06-07 Background: Successful pregnancy requires substantial maternal cardiovascular adaptation, including expansion and remodelling of the uterine arteries