The WormFood CURE: Screening for bioactive metabolites that antagonize the Caenorhabditis elegans Ras signaling pathway biorxiv.org 2026-06-07 Course-based Undergraduate Research Experiences (CUREs) provide an accessible, scalable platform for scientific discovery.
Gap junctions in the alimentary tract regulate reproductive span in C. elegans biorxiv.org 2026-06-07 Aging does not occur uniformly throughout an organism but is instead differentially regulated across distinct physiological systems.
Epigenetic conditioning improves sequence-based modeling of gene regulation across cell types and alleles biorxiv.org 2026-06-07 Epigenetic state modulates gene regulation in a manner not always predictable from DNA sequence alone, yet current genomic deep learning models do not
FBH1 Reverses Stalled Replication Forks via Sequential Unwinding of Nascent Strands biorxiv.org 2026-06-07 Replication fork reversal is a DNA damage tolerance mechanism important for genome stability that entails annealing of parental DNA to push the fork b
Development of a Staining-based Electrophoretic Mobility Shift Assay for Analyzing Pbx1, DNA and HoxA9 Interactions biorxiv.org 2026-06-07 Transcription factors (TFs) are master regulators of gene expression and control a wide range of cellular functions including embryonic development, s
TPR Domains Drive the Functional Phase Separation of HOP and its Regulation by Hsp90 and Hsp70 biorxiv.org 2026-06-07 HOP is a cochaperone that facilitates client transfer between two major chaperones, Hsp90 and Hsp70.
Small but Mighty: The Surprising Metabolic Range of a Bacterial Microcompartment biorxiv.org 2026-06-07 Bacterial microcompartments (BMCs) are protein-based metabolic modules increasingly investigated as potential intracellular nanoreactors.
Glycolipid MPIase is essential for the TAT (Twin-Arginine Translocation) pathway biorxiv.org 2026-06-07 TAT (Twin-Arginine Translocation) is a preprotein translocation system dedicated to membrane translocation of prefolded proteins in plants and bacteri
Overestimating zero-shot fitness prediction: Broad benchmarks mask local failures and practical limitations biorxiv.org 2026-06-07 Deep learning models have emerged as promising tools for navigating mutational landscapes in protein engineering.
A Passive-Oxygenation Silicone Platform for Biomass Production: Maximizing Labor Productivity and Process Efficiency in Cellular Agriculture Development biorxiv.org 2026-06-07 The commercial production of cell-based food is currently hindered by existing bioreactor technologies, which require substantial capital investment,
Macrocycle screening against the C-terminal region of CHD4 uncovers its role as an interaction hub in the formation of the nucleosome remodeling and deacetylase complex biorxiv.org 2026-06-07 The Nucleosome Remodeling and Deacetylase complex (NuRD) plays a key role in regulating hemoglobin expression in adult erythroid cells.
Chaperonin recognition of protein dynamics drives drug resistance biorxiv.org 2026-06-07 The emergence of drug resistance is typically driven by mutations that alter drug-target affinity, yet the role of host cellular machinery regulating
Recipient cell identity governs intracellular transport and membrane interactions of extracellular vesicles across species biorxiv.org 2026-06-07 Extracellular vesicles (EVs) function as a natural communication system, enabling transfer of biomolecules between cells.
Molecular dynamics insights into biomineralisation mediated by acidic intrinsically disordered proteins: a case study of molluscan Aspein from the pearl oyster Pinctada fucata biorxiv.org 2026-06-07 Biomineralisation is a ubiquitous phenomenon that still fascinates the scientific community.
Autoantibodies Drive Fc Gamma Receptor-Dependent Colon Inflammation During Immune Checkpoint Blockade biorxiv.org 2026-06-07 Immune-related adverse events (irAEs), particularly colitis, are major limitations of immune checkpoint inhibitor (ICI) therapy, but their mechanisms
High resolution spatial transcriptomics decodes the microenvironmental determinants of response to Nr-CWS therapy in cervical precancerous lesions biorxiv.org 2026-06-07 Immunotherapy with Nocardia rubra cell wall skeleton (Nr-CWS) can clear human papillomavirus (HPV) and induce regression of cervical precancerous lesi
Galectin and Myc enable cochlear progenitor expansion in vitro and in vivo biorxiv.org 2026-06-07 The neonatal cochlear epithelium harbors regenerative capacity, attributable to the transient greater epithelial ridge (GER).
Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis biorxiv.org 2026-06-07 Tertiary lymphoid structures (TLSs) are sites of immune organization in peripheral tissues that arise from chronic inflammation.
G quadruplex DNA facilitates a pervasive path to homologous recombination biorxiv.org 2026-06-07 Homologous recombination (HR) requires efficient homology search and strand invasion, yet how homologous templates are identified within the nucleus r
Correlative SHG-AFM imaging workflow for label-free quantitative analysis of collagen structure-function relationships biorxiv.org 2026-06-07 We present a user-friendly correlative second harmonic generation (SHG) and atomic force microscopy (AFM) imaging workflow for quantifying the nanomec
Why diabetes matters in dementia studies. Excluding diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimers disease biorxiv.org 2026-06-08 Diabetes is a major risk factor for Alzheimers disease (AD), and both diseases involve mitochondrial dysfunction.
Associations Between Plasma Lipoprotein(a) Levels and Circulating Monocyte Subsets Differ across Populations biorxiv.org 2026-06-07 Objective: Lipoprotein(a) [Lp(a)] is a causal cardiovascular disease (CVD) risk factor, with plasma concentrations generally higher in Black than Whit
Validation-free estimation of chronological age via close-kin biorxiv.org 2026-06-07 Age is a fundamental life-history parameter in animal ecology and wildlife management.
Exploring the diversity and spatial distribution of Anopheles mosquitoes and their associated Plasmodium species in Tanzania using the ANOSPP amplicon panel biorxiv.org 2026-06-07 Species-level identification of malaria vectors and parasites is essential for targeted vector control, surveillance, and clinical case management.
An Automated Wireless Seesaw System Enabling Spatial Separation of Action and Reward in Group-Housed Marmosets biorxiv.org 2026-06-07 Cooperation in social species is shaped by ongoing social relationships, partner choice, and group interactions, demanding experimental systems that p
An Itch Receptor Drives Melanoma biorxiv.org 2026-06-07 Mas-Related GPCR X4 (MRGPRX4) is a sensory neuron-restricted receptor for cholestatic itch.
Mechanistic pathway modeling reveals how IL-10 generates pleiotropic immune responses biorxiv.org 2026-06-07 IL-10 is a key anti-inflammatory cytokine whose activity is impaired in autoimmune diseases.
Nutrient control enables metabolic reconstruction of L. rhamnosus GG and analysis of secretions biorxiv.org 2026-06-07 Lacticaseibacillus rhamnosus GG (LGG) is an important gut commensal bacterial strain that has been extensively studied in both industrial and health s
Megalin (LRP2), prenatal betamethasone, and injury susceptibility in the developing kidney biorxiv.org 2026-06-07 Preterm infants undergo postnatal nephrogenesis and are often exposed to gentamicin (gent).
Fusion peptides of enveloped viruses actively mediate membrane fusion in model cell membranes biorxiv.org 2026-06-07 Enveloped viruses can enter host cells by fusing their membrane with that of the host cell, a process known as membrane fusion.