Integrated Evaluation of Osmotic and Antioxidant Defense Mechanisms in Cotton Genotypes Exposed to NaCl Stress biorxiv.org 2026-06-06 Salinity stress is one of the major abiotic factors limiting cotton productivity worldwide by inducing osmotic imbalance, oxidative stress, and metabo
Nucleoporin1 maintains male germ unit organization and transport in Arabidopsis pollen tubes, likely through shaping nuclear morphology biorxiv.org 2026-06-06 The male germ unit (MGU) in Arabidopsis pollen is comprised of one vegetative nucleus (VN) and two sperm nuclei (SN).
Dynamic gene gain and loss during the divergence of obligate biotrophic powdery mildew pathogens biorxiv.org 2026-06-06 Powdery mildew outbreaks can result in devastating crop losses across both horticultural and cereal crops.
Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions biorxiv.org 2026-06-06 Multicellular vertices are important cellular interfaces for mediating tissue dynamics across the epithelium.
Lysosomal lipid metabolism promotes tumor cell invasion through local energetics and membrane lipid remodeling biorxiv.org 2026-06-06 Metabolic vulnerabilities in cancer have been targeted primarily to suppress tumor growth, but less is known about the metabolic requirements for tumo
Magnetic Tweezers Experiments Reveal Increased Mechanical Sensitivity of the F2561Y Mutant in Von Willebrand Factor biorxiv.org 2026-06-06 The large glycoprotein von Willebrand factor (VWF) is essential for primary hemostasis.
Simulation of transcription factor clustering in nuclei from molecular kinetics biorxiv.org 2026-06-06 Transcription factors form clusters often described as condensates that exhibit emergent biophysical properties.
Temporal coding expands the bandwidth of GPCR-mediated neuromodulation biorxiv.org 2026-06-06 The advent of modern transcriptomic approaches has revealed a breadth of neuromodulatory G protein-coupled receptor (GPCR) co-expression far exceeding
iSBEM: An Open-Source Workflow for Automated ROI Targeting in Volume Electron Microscopy biorxiv.org 2026-06-06 Serial Block Face - Scanning Electron Microscopy (SBF-SEM) is a volume EM method suited to investigate the 3D architecture of tissues and even entire
Metformin Redirects Autophagy from Bulk Turnover to Mitochondrial Clearance biorxiv.org 2026-06-06 Metformin is the most widely prescribed antidiabetic drug and an active candidate for repurposing in oncology.
Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling biorxiv.org 2026-06-06 Across species, germ cells divide and differentiate as interconnected units, termed cysts.
Organ-specific fibroblast dynamics revealed via an integrated experimental-computational framework biorxiv.org 2026-06-06 Fibrosis is a progressive pathological process driven by dysregulated fibroblast activity and excessive extracellular matrix deposition, leading to sc
Constitutive plasma membrane interaction of active Rho GEF Ect2 inhibits cortex contraction pulses biorxiv.org 2026-06-06 During cell division, multiple guanine nucleotide exchange factors (GEFs), including the mitotic regulator Ect2 and Lbc-type GEFs, regulate the dynami
Vacuole pH loss triggers ESCRT-dependent plasma membrane remodeling to prevent amino acid toxicity biorxiv.org 2026-06-06 Loss of lysosomal or vacuolar acidity is a hallmark of aging, metabolic dysfunction, and cellular stress, yet how cells adapt to this condition remain
Piezo1 transduces mechanical signals to inhibit osteoclast fusion and coordinate bone homeostasis biorxiv.org 2026-06-06 Osteoclasts originate from bone marrow-derived macrophages, and their maturation relies on fusion of pre-osteoclasts into mature osteoclasts that main
Nir1-Nir2 Heterodimerization Confers Robustness to the Phosphoinositide Cycle biorxiv.org 2026-06-06 The phosphatidylinositol (PI) cycle maintains plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2) levels to sustain signaling and cellul
Matrix nucleotide homeostasis couples energetic state to mitochondrial translation biorxiv.org 2026-06-06 Mitochondrial protein synthesis must adapt to fluctuations in organellar energetic state to sustain oxidative phosphorylation and cellular homeostasis
Molecular basis of competence for neural induction in the chick embryo biorxiv.org 2026-06-06 Competence is the capacity of a cell or tissue to respond to a specific inducing signal from a neighbouring tissue, by changing its fate in a specific
Rab8a-positive vesicles transport Wnt8a along cytonemes in zebrafish embryogenesis. biorxiv.org 2026-06-06 Wnt signalling is a conserved pathway that orchestrates key developmental processes by regulating cell fate, proliferation, and tissue organisation.
MarkerScout: A Disease-Agnostic Machine Learning Framework for Biomarker Prediction from Multi-Scale Mechanistic Models biorxiv.org 2026-06-05 Identifying robust biomarkers from high-dimensional biomedical data is a central challenge in translational research, but candidate rankings produced
The canine respiratory epithelium is a permissive ecosystem for influenza interspecies transmission and emergence biorxiv.org 2026-06-05 The outcome of virus spillover ranges from dead-end infections to pandemics and is underpinned by host-pathogen interactions as well as evolutionary a
Galectin-3 recruitment at the Mycobacterium tuberculosis-containing phagosome is critical in macrophage but dispensable in epithelial cells biorxiv.org 2026-06-05 Mycobacterium tuberculosis (Mtb) virulence relies in part on its ability to induce phagosomal membrane rupture, enabling bacterial access to the host
Longitudinal RNA Seq analyses reveal the prominent role of Vagococcus in broiler meat spoilage microbiome biorxiv.org 2026-06-05 Background Raw broiler meat products are highly perishable, and microbial activity is the main factor limiting their shelf lives.
Inorganic sulfate transport by the Mycobacterium tuberculosis PE22/PPE36 complex biorxiv.org 2026-06-05 Mycobacterium tuberculosis (Mtb) encodes two multigene families with 169 members that are exclusive to mycobacteria, the pe and ppe genes.
Disrupting IFIT1-STAT2 viral evasion synergy yields live-attenuated flavivirus with enhanced immune priming biorxiv.org 2026-06-05 Diverse human viruses deploy a common immune-evasion strategy: viral 2'-O-methylation coupled with STAT2 antagonism.
Variable zinc concentrations among commercially available Mueller-Hinton Broth brands affects SIR interpretations during broth microdilution in vitro antimicrobial susceptibility testing with the novel metallo-beta-lactamase inhibitor APC148 biorxiv.org 2026-06-05 The well-known discrepancy between the in vitro and in vivo efficacy of {beta}-lactam antibiotics in metallo-{beta}-lactamase (MBL) containing Gram-ne
Minimal effective dose of telacebec administered orally in a murine model of leprosy biorxiv.org 2026-06-05 Leprosy treatment requires prolonged therapy with challenging patient follow-up. New regimens are needed to simplify current treatments.
MicroGrowAgents: An Agentic AI System for Microbial Cultivation Engineering biorxiv.org 2026-06-05 Microbial cultivation optimization remains labor-intensive and inefficient, requiring extensive experimental screening to identify suitable growth con
Characterization of velvet DNA-binding region by Aspergillus nidulans VelB biorxiv.org 2026-06-05 Velvet regulators characterized by a conserved velvet domain function as a central hub that coordinately govern fungal development, secondary metaboli
Quantitative stable isotope probing to measure in situ growth of protist populations biorxiv.org 2026-06-05 Soil protists shape microbial food webs and nutrient cycling, yet methods for measuring their population growth in soil have lagged behind the taxonom