Integrating longitudinal hyperspectral phenotyping with AI and GWAS to dissect barley waterlogging responses biorxiv.org 2026-06-05 Waterlogging is a major constraint on barley productivity, yet its dynamic, multi-phase nature makes it challenging to dissect using traditional pheno
NeuroCaptain v2 - Interactive Three-Dimensional fNIRS Optode and Probe Montage Design Platform Based on Blender biorxiv.org 2026-06-05 Significance: Accurate and reproducible optode placement is crucial for obtaining high-quality fNIRS data in both individual and group-level neuroimag
Brain dynamics supporting high cognitive performance reorganize after midlife biorxiv.org 2026-06-05 Quantifying functional brain aging trajectories at scale remains a fundamental challenge due to the scanner-bound limitations of traditional neuroimag
Global nonequilibrium cortical dynamics tie mid-level pupil-linked arousal to optimal task performance in humans biorxiv.org 2026-06-05 Ongoing fluctuations in brain state, largely driven by neuromodulators of arousal, shape how sensory inputs are processed and decisions are made.
Intrinsic Population Dynamics are a Neuronal Substrate for Visual Attention biorxiv.org 2026-06-05 Perception results from a dynamic interplay between the feedforward processing of sensory stimuli and intrinsic neural activity, which is often dismis
Scalable in vivo cardiac functional genomics with compressed AAV-Perturb-seq reveals a common mitochondrial response to perturbation biorxiv.org 2026-06-05 Efficient identification of new targets to treat human disease requires a scalable way to link genotype to phenotype directly in the target organ.
An enhancer-centric approach applied to human immune system epigenomes revealed the association of macrophage enhancers with cardiovascular disease biorxiv.org 2026-06-05 Complex diseases are influenced by both genetic and environmental factors.
SOD1 Catalyses Thiol Oxidation to Thiosulfinates biorxiv.org 2026-06-05 Cu/Zn superoxide dismutase (SOD1) is canonically regarded as a superoxide scavenging antioxidant yet is paradoxically associated with multiple disease
RISOP, a Reference-Assisted Approach for Enhanced Identification of Oxidized Phospholipids biorxiv.org 2026-06-05 Oxidized phospholipids (OxPLs) play critical roles in inflammation, ferroptosis, and other oxidative stress-associated processes, yet their systematic
inGSEA: An Improved Method for Gene Set Enrichment Analysis Using a Weighted Integral Statistic biorxiv.org 2026-06-05 Gene Set Enrichment Analysis (GSEA) is one of the most popular methods for transcriptomic analysis, yet its statistical power is limited when the biol
Insight across contexts: Phenomenological differences and the role of meaning in belief change biorxiv.org 2026-06-05 Insight is commonly studied in laboratory paradigms as a sudden shift in understanding accompanied by characteristic "Aha!" experiences.
Tracking multi-site somatic voltage dynamics via high-speed fiber photometry biorxiv.org 2026-06-05 Investigating neural circuit dynamics across distributed brain regions in awake, behaving animals is crucial for understanding complex behavior.
Hippocampal consummatory reward ensembles dynamically engage theta-SWR states during spatial working memory biorxiv.org 2026-06-04 Reward consumption consists of temporally structured sensory and behavioral episodes critical for memory-guided behavior.
Dysregulated flow responses drive pathogenesis in a cellular model of Sturge-Weber syndrome biorxiv.org 2026-06-04 Vascular diseases comprise a broad spectrum of conditions associated with organ dysfunction, yet how endothelial responses to mechanical forces drive
Passive acoustic monitoring of the rare orange-bellied parrot: automated detection using BirdNET-based transfer learning biorxiv.org 2026-06-04 Efficiently finding rare species is a perennial challenge in conservation science.
PETase Kubu enables near-complete enzymatic depolymerization of commercial PLA/PBAT blend mulch film biorxiv.org 2026-06-04 Agricultural mulch films improve crop productivity, but post-use recovery and recycling remain difficult because the films are thin, fragmented, dispe
Direct Detection and Atomic Modeling of Ligands in Cryo-EM Maps Using Deep Learning biorxiv.org 2026-06-04 Cryogenic electron microscopy (cryo-EM) has become an increasingly important for structure-based drug discovery by enabling characterization of intera
KBase Research Agent: Automated Multi-Agent Workflow Construction for Reproducible Genome Analysis biorxiv.org 2026-06-04 Constructing multi-step bioinformatics workflows, from read quality control through genome assembly to functional annotation, requires expertise in bo
Organoid-based colorectal tumor microenvironment model for immuno-oncology research biorxiv.org 2026-06-04 The development of cancer immunotherapies is hindered by the lack of human-relevant models that accurately translate to patient outcomes.
A Self-Priming Neural Chain Links Sequential Behaviors Across Timescales biorxiv.org 2026-06-04 Behavioral sequences are essential for survival, yet the neural mechanisms that link one action to the next remain incompletely understood.
Beyond forced choice: hyper-realistic AI faces reveal a four-cluster perceptual geometry of emotion biorxiv.org 2026-06-04 Forced-choice paradigms in facial emotion perception research require observers to commit to a single label and discard any simultaneous activation of
Falls Induced by Optogenetic Inhibition of Basal Forebrain Cholinergic Projections after Dorsomedial Striatal Dopamine Depletion in a Dual Disruption Model of Falling Vulnerability in Parkinson Disease biorxiv.org 2026-06-04 Falls are a common and debilitating feature of Parkinson's Disease (PD) patients.
Transition Metal-Weak Organic Acid Synergy Enables Rapid Bactericidal and sporicidal Activity biorxiv.org 2026-06-04 The global rise in antibiotic-resistant bacteria underscores the urgent need for alternative antimicrobial strategies capable of limiting bacterial gr
Immune-competent apical out airway organoids reveal distinct antiviral strategies of macrophages, neutrophils, and monocytes during influenza infection biorxiv.org 2026-06-04 The respiratory mucosa is the primary entry site for influenza virus and early antiviral immunity is governed there by interactions between epithelial
dCas allele sequestration (das-CRISPR): A Versatile New Method to Achieve Monoallelic Gene Editing in Mouse Embryos and in cell culture. biorxiv.org 2026-06-04 CRISPR-Cas9 technology is a powerful tool extensively used for genome editing in mouse and many other species.
Evolution and mechanism of MEIS2-mediated forelimb specialization in bats biorxiv.org 2026-06-04 The genomic basis of limb adaptations in tetrapods is thought to be largely driven by changes in gene regulation.
Ultra-Fast Implementation of Multivariate GWAS in Genomic SEM Using Flexible Analytic Estimation biorxiv.org 2026-06-04 Many medical, physiological, and psychiatric traits and disorders are highly polygenic and exhibit complex patterns of genetic sharing and differentia
DeltaMut: An Integrative Database of AlphaFold2-Derived Missense Variant Structures biorxiv.org 2026-06-04 The widespread use of next-generation sequencing has led to a surge in the number of identified variants with uncertain effects on protein function.
Correlative X-ray imaging and fluorescence microscopy biorxiv.org 2026-06-04 Imaging the structural organization inside cells in their native state is essential for understanding how the arrangement and interactions among molec
Vitality capacity preservation through lifelong aerobic exercise: a pathway to healthy ageing biorxiv.org 2026-06-04 Background The distinction between healthy and pathological ageing has led to the concept of vitality capacity (VC), which can be understood as the bo