EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogramming biorxiv.org 2026-06-04 Squamous cell carcinoma of the lung is a difficult-to-treat cancer with high prevalence in the US, and particularly in Kentucky.
PRMT1 arginine methylation of MCM4 restricts ssDNA gap formation during DNA replication biorxiv.org 2026-06-04 Replication-associated single-stranded DNA (ssDNA) gaps are increasingly recognized as major sources of genome instability, but how replisome-associat
Analysis of dRIF Composition Identifies ZNF346 as a Regulator of PKR Activation biorxiv.org 2026-06-04 Mammalian dsRNA sensors coordinate an array of cellular responses upon detection of dsRNA including translation repression, RNA degradation and interf
Aggregation of misfolded proteins in the sperm head impairs preimplantation embryo development biorxiv.org 2026-06-04 Paternal contributions to embryogenesis extend beyond DNA, yet the molecular cargo carried by sperm and its impact on development remain poorly define
Distinct Proteasomal Pathways Drive Oncogenic PPM1D Activation biorxiv.org 2026-06-04 PPM1D is a serine/threonine phosphatase and DNA damage response (DDR) regulator recurrently activated in cancer through amplification or C-terminal tr
Dynamic anatomy of the replisome under stress biorxiv.org 2026-06-04 When exposed to replication stress, the factors involved in DNA replication display differing responses that in many cases remain unexplained.
Big data analysis of animal movements in aquatic ecosystems with acoustic telemetry biorxiv.org 2026-06-04 Underwater receiver networks (passive acoustic telemetry systems) are deployed to track animals in aquatic habitats all over the world, but remarkably
Fluorescently-labeled split-QF hemidrivers: simplifying and enhancing methods enabling intersectional targeting of discrete cell types biorxiv.org 2026-06-04 Single cell transcriptomics data predict greater cell type diversity than previously appreciated, defined by combinatorial gene expression "codes".
Single-molecule nucleosome spacing coordinates chromatin fiber interactions biorxiv.org 2026-06-04 Nucleosome spacing influences higher-order chromatin fiber organization in vitro but how this relates to cellular chromosome structure remains content
Genomic, Transcriptomic, and Regulomic Analyses Do Not Support Profound Autism as a Distinct Biological Category biorxiv.org 2026-06-04 The Lancet Commission on the Future of Care and Clinical Research in Autism proposed the construct of "profound autism" as a recognizable subtype of a
Ploidy shapes gemcitabine response through altered potency and delayed cell death biorxiv.org 2026-06-04 Tumor ploidy is increasingly recognized as a determinant of therapeutic response, but the mechanisms by which ploidy shapes sensitivity to specific cy
Depression Severity Modulates the Cognitive Process of Facial Affect Representation: Evidence from a Genetic-Algorithm Face Synthesis Task biorxiv.org 2026-06-04 Depression is associated with biased facial emotion processing, yet existing paradigms measure only the recognition of pre-selected stimuli, conflatin
Longitudinal versus Cross-sectional effects of Age on MEG Power Spectra Parameters: Implications for Normative Models and Brain Ageing biorxiv.org 2026-06-04 Ageing produces changes in brain function.
One Circuit, Many Flow Fields: Mechanistic Models of Single-Trial Neural Dynamics biorxiv.org 2026-06-04 A single neural circuit can exhibit qualitatively different dynamics across trials: one circuit, many flow fields.
Rat hepatitis E virus infection has multiphasic viral replication kinetics in vivo biorxiv.org 2026-06-04 Background and Aims: Hepatitis E virus (HEV) infections are a growing threat to global public health.
ATG16L2 creates a VAIL-dedicated heterodimer with ATG16L1 biorxiv.org 2026-06-04 The ATG8 conjugation machinery supports both canonical autophagy, in which ATG8 proteins are lipidated on forming autophagosomes, and CASM, in which A
Invasion history reconstruction and potential distribution of the ambrosia beetles Euwallacea fornicatus and E. perbrevis (Coleoptera: Scolytinae), two global emerging pests biorxiv.org 2026-06-04 The global spread of invasive insects poses serious ecological and economic threats to forest ecosystems. Euwallacea fornicatus and E.
Genetic and epigenetic diversity of Salmonella enterica isolates from Kazakhstan from clinical and veterinary sources biorxiv.org 2026-06-04 Background: Salmonella enterica is a major cause of foodborne and invasive infections worldwide.
Nature-inspired Nanoparticle Adiposomes Enable Targeted Delivery of Hydrophobic Drug for Anti-Cancer Treatment biorxiv.org 2026-06-04 The predominance of lipophilic molecules in drug pipelines poses a fundamental delivery challenge in the aqueous physiological environment.
Stereotaxic targeting of the Dorsal Vagal Complex biorxiv.org 2026-06-04 The Dorsal Vagal Complex (DVC) is a critical brainstem relay for visceral sensory information, sympathetic regulation, and gut-brain communication.
Where the tree of life is empirically resolved, and where it is not: an open atlas of species-level phylogenies and their archival uncertainty biorxiv.org 2026-06-04 Comparative and macroevolutionary biology depends on knowing two things at once: where the species-level tree of life is empirically resolved, and whe
Proteomics-constrained deconvolution reveals spatial cell-type programs in tumours biorxiv.org 2026-06-04 Accurately resolving cell-type mixtures in spatial transcriptomics remains challenging, particularly in heterogeneous tumours where cell populations a
Hierarchical classification of immune cell transcriptomes at population-scale biorxiv.org 2026-06-04 Accurate immune cell classification is essential for interpreting single-cell RNA sequencing (scRNA-seq) data.
Oncostatin M cytokine promotes breast cancer progression by remodelling the extracellular matrix and activating integrin signalling in cancer cells biorxiv.org 2026-06-04 Tumours reshape their surrounding extracellular matrix (ECM), creating a microenvironment with altered chemical and mechanical properties.
Lifespan Analysis of the Lung Epithelium Reveals Inflammatory Reprogramming and Regenerative Decline biorxiv.org 2026-06-04 Aging is a major risk factor for chronic lung diseases, associated with chronic low-grade inflammation (inflammaging) and impaired epithelial regenera
On the Distribution of Free-Energy in Metabolism biorxiv.org 2026-06-04 Chemical potential is coupled to cellular processes by the flow of metabolites through catalytic networks known collectively as metabolism.
Supraphysiological Estradiol During Ovarian Stimulation Reveals Microbiome Resilience and Prevotella Opportunism biorxiv.org 2026-06-04 How the oral ecosystem responds to acute, high-amplitude hormonal perturbations remains poorly defined.
Probiotic wheat sprouts: A novel functional food developed through Lacticaseibacillus casei inoculation with improved bioactivity and probiotic survival biorxiv.org 2026-06-04 In this research we inoculated Lacticaseibacillus casei (L. casei) into wheat sprouts and studied the viability of the bacteria in the sprout. L.
Identification of Beneficial Bacterial Strains for Tomato Growth Promotion and Biocontrol of Bacterial Canker Caused by Clavibacter michiganensis biorxiv.org 2026-06-04 Bacterial canker of tomato, caused by Clavibacter michiganensis (Cm), remains difficult to control due to lack of effective management options.
PonA2?s contributions to biofilm and colony formation independent of its catalytic domains in Mycobacterium smegmatis. biorxiv.org 2026-06-04 Biofilm and colony growth creates microenvironments that require coordinated localization and function of cell surface molecules within the membrane.