Genetic Information Processing Complexity as a Determinant of Virus Diversity biorxiv.org 2026-06-03 Viruses exhibit diverse genome architectures and replication strategies that shape their evolutionary trajectories and taxonomic diversification.
Convergent genome- and gene-level constraints shape repeated environmental adaptation in grasses biorxiv.org 2026-06-03 Grasses (Poaceae) dominate terrestrial ecosystems and sustain global food security, yet the genomic principles enabling their repeated adaptation to e
Horizontally acquired mitochondrial alternative oxidase contributes to springtail bioenergetics and life belowground biorxiv.org 2026-06-03 Springtails are tiny hexapods that occupy habitats ranging from above the soil surface to hypoxia-prone belowground environments, yet the physiologica
Divergent evolution of the PRPS enzymes across the tree of life biorxiv.org 2026-06-03 The phosphoribosyl pyrophosphate synthetase (PRPS) enzyme plays a central role in core biochemical pathways across all life, reflecting its deep evolu
Breeding pig transport drives the dispersal of swine influenza A virus across Europe biorxiv.org 2026-06-03 Pigs serve as reservoirs of former human influenza A virus (IAV) H1N1 and H3N2 lineages and act as mixing vessels for diverse strains, facilitating th
Deciphering and Improving Human Homogentisate 1,2-Dioxygenase Function Through Knowledge Gaining Directed Evolution: Implications for Alkaptonuria biorxiv.org 2026-06-03 Human homogentisate 1,2-dioxygenase (HGD) catalyses the oxidative cleavage of homogentisic acid (HGA) to maleylacetoacetate (MAA), a key step in tyros
More isn't always better: Too much exoskeleton torque can disrupt balance biorxiv.org 2026-06-03 Wearable exoskeletons are a promising tool for augmenting balance and reducing fall risk.
Auditory Profiles in Tinnitus are Age-Dependent: Electrophysiological and Behavioral Evidence biorxiv.org 2026-06-03 Tinnitus is commonly associated with hearing loss, yet it can also occur in individuals with clinically normal audiometric thresholds.
Novel recombinant bovine papular stomatitis virus expressing foot and mouth disease virus-like particles elicits protective levels of neutralizing antibodies in cattle biorxiv.org 2026-06-03 Foot-and-mouth disease (FMD) remains a major burden in endemic regions, where inactivated vaccines are constrained by cost, short duration of immunity
A novel tumor-targeted interferon-α/-β receptor 1 antagonist increases replication of oncolytic vesicular stomatitis virus in a mouse mesothelioma model biorxiv.org 2026-06-03 Type I Interferons (IFN-I) are cytokines with pleiotropic activities involved in antiviral and antitumor immune responses.
Population Resilience Under Environmental Deterioration in Socially Monogamous Systems with Mutual Mate Choice biorxiv.org 2026-06-03 Rapid environmental change and biodiversity loss make it increasingly important to identify factors influencing population extinction risk.
Genetic Architecture of Reproduction and Longevity in Historical Dutch Cohorts biorxiv.org 2026-06-03 Life-history theory predicts a trade-off between reproduction and survival, often invoked to explain human ageing through antagonistic pleiotropy, yet
Evolution of supernumerary chromosomes in wheat blast fungal pathogens biorxiv.org 2026-06-03 A genome of Pyricularia oryzae (synonym Magnaporthe oryzae), the fungus that causes blast disease on diverse grass species, has seven core chromosomes
Independent evolutionary trajectories of genomic repeats and non-repeat genome features in Actinomycetota biorxiv.org 2026-06-03 Genomic repeats, particularly simple sequence repeats, influence genome stability and gene regulation.
De novo mutation of an RNA virus is increased in the presence of engineered synonymous mutations that disrupt RNA structural elements biorxiv.org 2026-06-03 Using a combination of methods including selective 2?-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq), a complete RNA structure
Segmentation gene expression and function in Vanessa cardui, an emerging model for Lepidoptera biorxiv.org 2026-06-03 Although all insects are segmented, the genes that control this process vary across species.
Complex adaptive architectures constrain the pace of adaptations sweeping across human gut microbiomes biorxiv.org 2026-06-03 Recent work has shown that commensal gut bacteria can evolve rapidly within hosts on short timescales of days to months, fueled by the enormous mutati
Sea-level and climate changes drive lineage diversification in the imperiled Venus flytrap (Dionaea muscipula J. Ellis, Droseraceae) biorxiv.org 2026-06-03 Venus flytrap (Dionaea muscipula) is an insectivorous plant in the monotypic genus Dionaea, endemic to the Southeastern United States, and found in a
Constraining pesticide resistance using evolution-informed selection regimes biorxiv.org 2026-06-03 The rapid evolution of pesticide resistance in sexually reproducing pests threatens global food security, yet the evolutionary principles needed to de
Explaining the rapid evolution of mammalian meiotic recombination proteins biorxiv.org 2026-06-03 Meiotic recombination, the exchange of genetic material between parental chromosomes during gamete production, is critical for fertility, genome stabi
Distinct associations between multimodal brain measures and psychopathology domains predict adolescent functioning biorxiv.org 2026-06-04 Adolescent psychopathology is partly rooted in measurable disruptions across key neural networks, yet the field still lacks an integrated, multimodal
Emergence of social recognition in auditory and integrative circuits during pair bonding biorxiv.org 2026-06-04 Social relationships profoundly shape the perception of communication signals.
Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease biorxiv.org 2026-06-04 CLN3 disease, the most common form of the Neuronal Ceroid Lipofuscinoses (NCLs), causes progressive cognitive decline and language impairment in human
Measurement Equivalence of On-Scalp OPM-MEG and Cryogenic MEG for Auditory and Somatosensory Cortical Mapping Across Development biorxiv.org 2026-06-04 Wearable optically pumped magnetometer magnetoencephalography (OPM-MEG) reduces sensor-to-cortex distance compared with conventional cryogenic SQUID-M
Sensorimotor encoding of epistemic value during goal-directed causal learning biorxiv.org 2026-06-04 Understanding the neural and computational mechanisms underlying goal-directed causal learning is a central challenge in both cognitive neuroscience a
Multiplexed dopamine neurons predominate in the ventral midbrain of young macaques biorxiv.org 2026-06-04 Dopamine (DA) is important in many fundamental behaviors, including positive and negative reinforcement, incentive salience, and decision-making.
Theta phase and theta-gamma coupling organise the spoken language network biorxiv.org 2026-06-04 Speech production requires rapid coordination of conceptual and lexical processes across distributed cortical networks, yet the neurophysiological mec
Visibly Transparent, Near-Infrared Absorbing Nanofluids Enable High-Efficiency and Safe Laser Lithotripsy biorxiv.org 2026-06-03 Laser lithotripsy (LL) is the gold standard for urinary stone management yet maximizing ablation efficiency while maintaining procedural safety remain
Convergent Evolution in Tumor Genomes Targets Functional Domains biorxiv.org 2026-06-03 Tumor evolution is shaped by selective pressures that repeatedly favor similar functional outcomes across genetically distinct cancers.
Fucoidan from brown algae Laminaria japonica trigger apoptosis in colon cancer cells biorxiv.org 2026-06-03 In many cases, cancer cells develop resistance to chemotherapy and other cancer treatments.