D-alanine aminotransferase (Dat) promotes Staphylococcus aureus colonization fitness on human nasal respiratory epithelium biorxiv.org 2026-06-04 Nasal colonization by Staphylococcus aureus is an established risk factor for invasive infection, yet bacterial determinants promoting fitness on huma
Learning residue-level context for modeling protein-protein interactions biorxiv.org 2026-06-04 Protein language models (PLMs) enable prediction of protein properties by learning residue-level features from sequence, yet most PLM-based approaches
Single-cell characterization of tumor immune landscapes in colorectal cancer humanized mice biorxiv.org 2026-06-04 Colorectal cancer (CRC) displays inter-patient heterogeneity in molecular tumor features and immune cell composition, which influence therapy response
G-CSF associates with poor survival in cutaneous melanoma and promotes metastasis through coordinated effects on macrophages and tumor cells biorxiv.org 2026-06-04 Macrophage-melanoma interactions critically shape the tumor microenvironment, yet the cytokine networks driving this process remain incompletely under
Multiscale modeling of the subcutaneous administration of peptides biorxiv.org 2026-06-04 With the increasing prevalence of subcutaneous administration of peptides, understanding their release and absorption is key to designing formulations
Peacock Eye Disease Management (PedMan) System: Validation and Implementation in Addressing Key Biological Questions biorxiv.org 2026-06-04 Peacock eye disease, caused by Venturia oleaginea, is a major foliar disease of olive (Olea europaea) in Mediterranean regions, resulting in defoliati
Sleep immediately after noise overexposure worsens tinnitus in mice biorxiv.org 2026-06-04 Subjective tinnitus is the most common auditory phantom perception in the absence of an acoustic stimulus yet there is no cure nor widely effective tr
Low-dimensional prefrontal representations of objects during working memory biorxiv.org 2026-06-04 There is an ongoing debate regarding the dimensionality of neural representations.
Targeting Nitric Oxide Synthase 2 Reverses Learning Deficits in an Oligodendrocyte-Focused Model of Costello Syndrome biorxiv.org 2026-06-04 Myelination of axons by oligodendrocytes (OLs) greatly improves information processing in the brain; consequently, compromised myelin negatively impac
Dorsal striatal circuit mechanisms contributing to astrocyte modulation of alcohol-related behaviors biorxiv.org 2026-06-04 Background: The dorsolateral striatum (DLS) is a key site for coordinating the alcohol-induced stimulant response, a behavioral marker predictive of f
Adaptive Bayesian localization of motor representation areas biorxiv.org 2026-06-04 Transcranial magnetic stimulation (TMS) enables non-invasive localization of cortical motor representations, with important clinical applications in p
Differences in microbial community structure and soil nutrients between healthy and diseased soils of Zingiber officinale biorxiv.org 2026-06-04 To investigate the differences in soil nutrients and microbial community structure in the rhizosphere between healthy and diseased Zingiber officinale
Comparative analysis of neuronal proteolytic pathways reveals neuron-specific and sub-compartmental-specific capacities with aging biorxiv.org 2026-06-04 Proteostasis is essential for maintaining neuronal function, and its dysregulation is a hallmark of aging and neurodegeneration.
An interpretable machine learning framework for dog breed inference and ancestry decomposition biorxiv.org 2026-06-04 The over 300 currently recognized breeds of domesticated dogs are the culmination of centuries of intense artificial selection and recurrent populatio
Theta gates and routes information in the frontal cortex biorxiv.org 2026-06-04 Theta (4-10 Hz) oscillations seem well-suited for coordinating neural activity.
Neural decoding of speech using deep neural ensembles biorxiv.org 2026-06-04 Speech brain-computer interfaces (BCIs) can restore rapid communication to people with paralysis, but decoding errors still limit performance.
The emergent mental operation of the learning brain biorxiv.org 2026-06-04 How does the learning brain give rise to emergent mental operations that enable skill internalization and generalization?
Dual-channel whole-brain imaging reveals distinct dopamine and calcium dynamics in walking Drosophila biorxiv.org 2026-06-04 Simultaneous recording of intra- and extracellular neuronal signals across the brain during behavior is crucial for unraveling brain information proce
Modulation of Ferroptosis During Early Mycobacterium tuberculosis Infection Contributes to Beijing Lineage Strain SA161 Virulence biorxiv.org 2026-06-04 Although spread of internalized Mtb from the initial infected alveolar macrophages (AMs) is a crucial determinant of infection outcomes, the role of c
Tet Trim-Away: A conditional rapid protein degradation system for Tetrahymena thermophila biorxiv.org 2026-06-04 Tetrahymena thermophila is a ciliated protist that has played pivotal roles in biological discovery.
α-Synuclein and γ-Tubulin Cooperatively Regulate Activity-Evoked Presynaptic Microtubule Nucleation to Gate Dopamine Release biorxiv.org 2026-06-04 alpha-Synuclein has long been implicated in the regulation of synaptic activity, but the molecular basis that underlies this function has been elusive
Estimating spatially adjusted temperature-dependent time-varying reproduction numbers for vector-borne diseases biorxiv.org 2026-06-04 Estimating the effective reproduction number is crucial for understanding and managing infectious disease outbreaks.
Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis biorxiv.org 2026-06-04 Extended duration of under-treated psychosis (DUP) is among the strongest predictors of poor outcome, yet diagnostic heterogeneity impedes treatment m
Validation of optogenetic approach to investigate fatigable weakness using a zebrafish model of congenital myasthenic syndrome biorxiv.org 2026-06-04 Congenital myasthenic syndromes (CMS) are rare inherited diseases of the neuromuscular junction (NMJ).
Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling biorxiv.org 2026-06-04 Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature.
Language Modeling Materializes a World Model of Protein Biology biorxiv.org 2026-06-04 Proteins are fundamental to life.
A horizontally transferred fungal deubiquitinase facilitates insecticides resistance in whitefly biorxiv.org 2026-06-04 Horizontal gene transfer (HGT) has enabled insects to acquire novel genetic material that can fuel adaptation to environmental change.
Integrated valorization of glycerol and PET into lipids and PHAs using an engineered Yarrowia lipolytica strain and a Pseudomonas-Comamonas consortium biorxiv.org 2026-06-03 The accumulation of plastic waste necessitates innovative strategies that convert polymer carbon into value-added products.
Vertical stratification drives additive prokaryotic diversity in beech forest floors, while site conditions shape boundary layers biorxiv.org 2026-06-03 The forest floor is a key interface regulating carbon and nutrient processing and transfer to the mineral soil, yet it is threatened by climate-change
The hypercubic Mk model in reduced state space for the coupled, reversible coevolution of multiple binary characters biorxiv.org 2026-06-03 Many scientific questions involve the coevolution of coupled, binary features over time -- from phenotypes in evolutionary biology to mutations in can