(2R,6R)-Hydroxynorketamine elicits rapid antidepressant effects by promoting astrocytic μ-δ opioid receptor heterodimerization biorxiv.org 2026-06-03 Ketamine produces rapid antidepressant effects but is constrained by psychotomimetic properties and abuse potential.
From prediction to engagement: defining tumor-reactive T cells through biological interaction biorxiv.org 2026-06-03 Abstract Adoptive T-cell therapy (ACT), particularly tumor-infiltrating lymphocyte (TIL) therapy, demonstrates that durable regression of solid tumors
Molecular mechanisms underlying the prepupal-instar-forming metamorphosis in black soldier fly (Hermetia illucens) biorxiv.org 2026-06-03 The black soldier fly (Hermetia illucens, Diptera) undergoes an atypical metamorphic program in which a distinct non-feeding prepupal instar precedes
Modelling habitat suitability for multiple priority weed species to predict invasion hotspots for strategic management in complex landscapes biorxiv.org 2026-06-03 Established invasive alien plant species require ongoing, costly management to reduce harm to agricultural and environmental values.
Enemies, more than sex, shape butterfly post-mating odor evolution biorxiv.org 2026-06-03 Not all odors influencing mating behavior evolve as sex pheromones.
The Role of Osteocyte Estrogen Receptor β in Bone Mass Maintenance and Tibial Stiffness Following Sex Hormone Withdrawal in Male and Female Mice biorxiv.org 2026-06-03 Sex hormones are essential regulators of skeletal maintenance, but the cell-specific mechanisms by which osteocytes mediate the skeletal consequences
Applying Spatial Statistics to Spatial Transcriptomics Reveals Local Association Between M2-like Macrophages and Fibrosis in Diabetic Kidney Disease biorxiv.org 2026-06-03 Renal fibrosis is the common final pathway of chronic kidney disease (CKD), driven in part by myofibroblast-mediated extracellular matrix deposition.
Linezolid Acts as a Selective Inhibitor of the JAK2V617F Mutation biorxiv.org 2026-06-03 The JAK2V617F (JAK2VF) driver mutation is found in 95% of patients with polycythemia vera (PV), a progressive myeloproliferative neoplasm.
Brain states recur across diverse narrative contexts during longitudinal viewing biorxiv.org 2026-06-03 What does the brain do during the continuous, varied experience of watching a story unfold?
Plant growth forms shaping biodiversity patterns can guide conservation planning on the Qinghai-Tibet Plateau biorxiv.org 2026-06-03 Plant growth forms effectively reflect profound evolutionary adaptations that underpin ecosystem functioning; however, how their biogeographic dispari
Catch me if you can: Arabidopsis thaliana lags in adaptation to contemporary climate change biorxiv.org 2026-06-03 Anthropogenic climate change fosters unprecedented temperature challenges, with each year breaking a temperature record.
Integrative genomics reveals shared and stress-specific adaptive pathways underlying acidic soil-associated metal toxicity in rice biorxiv.org 2026-06-03 Soil acidity-associated toxicities of aluminum (Al), cadmium (Cd), and manganese (Mn) severely constrain rice productivity in upland ecosystems.
Single-cell multimodal profiling of pan-cancer cell lines uncovers gene regulatory principles underlying intrinsic cell states and environmental features biorxiv.org 2026-06-03 Cancer arises from extensive genetic and epigenetic alterations that reshape chromatin, transcriptional regulation, and malignant cell states.
Decoding Chromosome Radiosensitivity in G0-Phase PBMCs: Genomic Determinants, Age, Sex effects, and Implications in Radiation Dose Assessment biorxiv.org 2026-06-03 Low-dose ionizing radiation from natural and anthropogenic sources is typically not of significant concern under normal conditions.
Information Geometry of Intracellular Compartment Coupling Reveals Transcriptomic State Transitions in Single Cells biorxiv.org 2026-06-03 Single-cell transcriptomic analyses typically characterize cellular states using gene-expression variability, dimensionality reduction, and trajectory
Quilting the Brain: Whole-Brain iEEG Reconstruction via Incomplete Observation Linear Mixed Models biorxiv.org 2026-06-03 Mapping human brain function at high spatiotemporal resolution is constrained by the physical limitations of non-invasive imaging and the sparse sampl
ViTAMIn-O: Democratizing computer vision-based machine learning for stem cell research biorxiv.org 2026-06-03 Deep Learning (DL) holds exciting potential in automating the prediction of organoid differentiation results.
ROTS 2.0: A reproducibility-driven framework for robust statistical modeling across diverse high-throughput omics study designs biorxiv.org 2026-06-03 Reproducibility is fundamental to reliable scientific discoveries.
Kindlin-1 loss disrupts vascular and extracellular matrix organisation to sustain hypoxia in cutaneous squamous cell carcinoma biorxiv.org 2026-06-03 Kindlin-1, encoded by FERMT1, is an essential integrin co-activator that regulates cell extracellular matrix (ECM) adhesion, tissue architecture, and
Tracing Sticky Trails: The Historical Biogeography of Australia's Glandular Goose-foots (Dysphania, Chenopodioideae, Amaranthaceae) biorxiv.org 2026-06-03 Abstract Aim The overarching aim of this study is to reconstruct the spatiotemporal evolutionary history of Australian Dysphania, including testing th
Distance Mapping and Variable-Specific Geometry of Goal-Relevant Frames in the Retrosplenial Cortex biorxiv.org 2026-06-03 Goal-directed navigation requires animals to continuously update their position relative to an unmarked goal.
High-order brain interactions distinguish wakefulness, anaesthesia, and recovery induced by deep brain stimulation biorxiv.org 2026-06-03 Understanding how consciousness depends on large-scale brain interactions is key for both the neuroscience of consciousness and clinical translation.
Phosphorylation-dependent regulation of Hsp70 chaperones stimulates client recruitment biorxiv.org 2026-06-03 Molecular chaperones of the Hsp70 family play essential roles in maintaining proteostasis, particularly under conditions of cellular stress.
Hyaluronic Acid Plays Differential Molecular Weight and Concentration Dependent Pathway Centric Changes to Human Lung Derived Microvascular Endothelial Cells in Culture biorxiv.org 2026-06-03 Background Hyaluronan (HA) is a major extracellular matrix glycosaminoglycan that regulates vascular integrity and immune signaling in the lung.
Loss of tissue specificity and recurrent pan-cancer activation define a conserved oncogenic microRNA class biorxiv.org 2026-06-03 MicroRNAs (miRNAs) act as crucial post-transcriptional regulators of large gene networks, and their aberrant expression drives key oncogenic processes
Reachability-Preserving Minimum Edge Cut Problem and Applications in Biology biorxiv.org 2026-06-03 Biological pathway analysis often requires identifying interventions that block reachability to an undesirable state, such as a disease-associated mod
Optimized MALDI-TOF mass spectrometry enables reliable identification of freshwater snails from schistosomiasis-endemic areas in Mauritania biorxiv.org 2026-06-03 Freshwater snails act as intermediate hosts for parasites affecting both humans and livestock, including schistosomes.
Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in Schizophrenia biorxiv.org 2026-06-03 Schizophrenia (SCZ) is a severe and debilitating neurodevelopmental disorder with lifelong impact on everyday life.
Cell-specific regulatory circuits connect genetic variation to disease susceptibility biorxiv.org 2026-06-03 Genome-wide association studies have identified thousands of variants associated with immune-related diseases, yet most lie in non-coding regions, com
Multiome Profiling Reveals Astrocyte and Neuroendocrine Targets of Prenatal Acoustic Programming in Zebra Finch Embryos biorxiv.org 2026-06-03 Climate change is driving more frequent and severe heat events, yet the developmental mechanisms by which organisms anticipate and adapt to thermal st