Aberrant chromatin remodeling influences human neural cell fate change in Trisomy 21 biorxiv.org 2026-06-03 Correct neural progenitor cell (NPC) fate specification is essential to produce the full complement of neurons and glia needed for proper brain struct
Short-Term Developmental Trajectories of Dorsal-Ventral Pathways and Their Relationships with First-Grade Learning biorxiv.org 2026-06-03 The first year of formal schooling is a year of foundational reading and math learning, and individual differences emerging within this single year pr
Transcriptomic profiling of the human habenula reveals a shared molecular architecture across mood disorders biorxiv.org 2026-06-03 The habenula is a critical regulator of monoaminergic and reward circuitry and is increasingly implicated in the neurobiology of mood disorders.
Attenuated adaptive growth of interpersonal synchrony in autism biorxiv.org 2026-06-03 During social interactions, people continuously align their movements and rhythms, a process known as interpersonal synchrony that supports rapport, m
Spatiotemporal Decoding of Explore-Exploit Decisions in the Human Brain biorxiv.org 2026-06-03 Adaptive behavior requires flexibly shifting between exploiting familiar rewards and exploring novel opportunities.
The ASD Risk Gene D5Ertd579e Regulates Synaptic Plasticity and Selective Autism-Related Behaviors biorxiv.org 2026-06-03 Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition shaped by contributions from hundreds of genes, many of which remain po
Hepatic stearoyl-CoA desaturase-1 is specifically suppressed by dextran sodium sulfate but does not influence colitis sensitivity biorxiv.org 2026-06-02 The delta-9 desaturase stearoyl-CoA desaturase-1 (SCD1) catalyzes the conversion of saturated fatty acids to monounsaturated fatty acids (MUFA) and is
A multimodal perturbation atlas defines the phenotypic resolution of cellular morphology. biorxiv.org 2026-06-02 Because cells are complex dynamical systems, modeling cellular behaviors requires methods that capture how cells evolve across time, environments, and
The mitochondrial genome of the hammerhead flatworm Bipalium nobile and its phylogenetic implications biorxiv.org 2026-06-02 We sequenced the nearly complete mitochondrial genome of the hammerhead flatworm Bipalium nobile Kawakatsu and Makino, 1982 using short-read sequencin
Enhanced glymphatic CSF tracer influx during α2-adrenergic agonist anesthesia is independent of tracer injection duration biorxiv.org 2026-06-02 The glymphatic system mediates brain-wide cerebrospinal fluid (CSF) transport and is highly sensitive to brain state.
Radiosensitization of Glioblastoma by the K-ras Inhibitor RMC-6236 biorxiv.org 2026-06-02 Purpose: Glioblastoma (GBM) is characterized by poor clinical outcomes and marked resistance to radiotherapy.
Resonance-driven enhancement of sleep spindles using thalamic temporal interference stimulation biorxiv.org 2026-06-02 Sleep spindles are hallmarks of non-rapid eye movement sleep and support memory consolidation, yet remain difficult to modulate non-invasively.
Differential vulnerability of CA1 pyramidal neuron cell types in the 5xFAD Alzheimer's disease mouse model biorxiv.org 2026-06-02 Selective neuronal vulnerability is a defining feature of Alzheimer's disease, yet how neurodegeneration unfolds across defined hippocampal CA1 pyrami
Efficient ageing: Simulated lesion of the structural connectome reveals optimised decline in the healthy ageing brain biorxiv.org 2026-06-02 Healthy ageing is associated with widespread white-matter change and altered connectome organisation, yet the link between local microstructural decli
Information-dependent eye-hand coordination emerges from active vision biorxiv.org 2026-06-02 In daily activities, humans rely on visual information to plan hand movements, making the extraction of task-relevant information through eye gaze a k
Atomic layer deposition for core-shell microparticle vaccines enabling programmable antigen delivery to lymph nodes enhance humoral immune responses biorxiv.org 2026-06-02 Technologies that simplify complex dosing regimens as single-shot immunizations may be important for vaccines against difficult to neutralize pathogen
Fat body driver expression report across Drosophila melanogaster tissues and sex biorxiv.org 2026-06-02 Drosophila melanogaster serves as a valuable model system for advancing our understanding of adipose tissue given its analogous organ systems, conserv
A Human Vocal Fold Organ-On-Chip for Studying Platform-Dependent Mucosal Responses to Particulate Matter biorxiv.org 2026-06-02 Background. Coarse particulate matter (PM10) deposits at the vocal fold (VF) mucosa, yet upper airway responses remain poorly characterized.
Nutrient-responsive and DAF-16/FoxO target H1 histone HIL-1 promotes resistance to starvation and bacterial pathogens in Caenorhabditis elegans biorxiv.org 2026-06-02 Insulin/IGF-1 signaling (IIS) mediates metabolic and developmental acclimation to stressful conditions including starvation.
Simple synthesis and functionalisation of α-hydroxyglycine-containing peptide fragments biorxiv.org 2026-06-02 We report here a method for the chemical synthesis of Fmoc-protected -hydroxyglyine (-OH-Gly) dipeptides.
Equitable Health Intelligence: An Open Benchmark of Multi-Population Machine Learning for Omics-Based Cancer Prognosis biorxiv.org 2026-06-02 Purpose: Machine learning (ML) models for omics-based cancer prognosis are often trained on data from predominantly European-ancestry populations, pro
Genome Organizer SATB1 selectively activates a defined subset of EMT genes driving metastatic breast cancer biorxiv.org 2026-06-02 SATB1 reshapes chromatin architecture and transcriptional programs to promote breast cancer metastasis.
Iron-deficiency in the tumor microenvironment reprograms tumor-immune interactions in a sex biased manner biorxiv.org 2026-06-02 Background: Glioblastoma (GBM) is a sex-biased disease characterized by higher incidence and poorer survival in males.
Pathology-Targeted EP4 Agonism Reverses Fibrosis in a Rat Model of DMD biorxiv.org 2026-06-02 Duchenne muscular dystrophy (DMD) presents a critical therapeutic gap in adolescent patients, where fibro-fatty muscle replacement and depletion of th
Two Genomes, One Metabolome: Mitonuclear Incompatibility Remodels Developmental Metabolism and Fitness in Drosophila biorxiv.org 2026-06-02 Mitochondrial-nuclear (hereafter mitonuclear) genetic variation can alter cellular bioenergetics and metabolism via jointly encoding the subunits of o
Harmala alkaloids regulate cell division planes in plants biorxiv.org 2026-06-02 Plants produce a vast diversity of specialized metabolites that function as chemical defenses against herbivores, pathogens, and competing plants.
Rank dependency of rescaled pruning in recurrent neural networks biorxiv.org 2026-06-02 Throughout development and maturity, neural circuits undergo massive synaptic pruning, yielding highly sparse connectivity while preserving robust pop
A genetic tool targeting brain GPR75 biorxiv.org 2026-06-02 G-protein-coupled receptor 75 (GPR75) has emerged as an important mediator in diet-induced obesity (DIO) and a promising therapeutic target for anti-o
DeMoDa: A global open access database for comparative research in human dental morphological variation biorxiv.org 2026-06-02 Human dental morphology is diverse and varies within and between populations.
Fine-scale landscape genomics show asymmetric patterns of gene flow for the invasive mosquito Aedes albopictus biorxiv.org 2026-06-02 Mosquito-borne viruses like dengue, Zika, and chikungunya pose increasing health risks in the United States due to the expanding range of Aedes albopi