Voxel-wise tracer kinetic model selection for DCE-MRI measurements of blood-brain barrier leakage biorxiv.org 2026-06-02 Purpose: To apply voxel-wise tracer kinetic model selection, characterise the spatial distribution of best-fitting models across the brain, and evalua
HEALTHY AGING AS INFORMATION DIVERGENCE IN THE MULTIPLEX BRAIN biorxiv.org 2026-06-02 Understanding the co evolution of the human brain s structural scaffold and functional traffic across the adult lifespan remains a fundamental challen
Enabling Stable Cortical Reconstruction in the HCP Pipeline at Standard Resolution Using FastSurfer Integration with Hybrid T2w- and T1w-based Masking biorxiv.org 2026-06-02 This study aimed to enable stable cortical reconstruction within the Human Connectome Project (HCP) pipeline under standard-resolution (1 mm3) conditi
NMDA Receptor Subunit NMR-2 Regulates Pathogen-Induced Immune Responses via the Nervous System in C. elegans biorxiv.org 2026-06-02 Neural control of innate immunity must balance restraint of basal immune activity with rapid activation upon pathogen encounter.
Immune activation during broadly neutralizing antibody-mediated HIV suppression prior to post-intervention control biorxiv.org 2026-06-02 Broadly neutralizing antibodies (bNAbs) have been associated with enhancement of HIV-specific T or B cell responses and sustained partial control of H
immgenT CD4: a reference landscape of mouse CD4+ T cell biorxiv.org 2026-06-02 CD4+ T cells are orchestrators of the immune system with diverse effector functions.
Altering the ribosome exit tunnel to improve consecutive incorporation of challenging monomers biorxiv.org 2026-06-02 Ribosomes are capable of incorporating a wide array of natural and unnatural monomers into growing polymer chains, but can be stalled by monomers with
Quantitative biophysical analysis of human septin hexamer and octamer self-assembly on model membranes biorxiv.org 2026-06-02 Septins are GTP-binding cytoskeletal proteins that shape and compartmentalize the plasma membrane.
Simulation-driven discovery of morphology-function relationships in microswimmers biorxiv.org 2026-06-02 For more than a billion years, microorganisms have evolved complex strategies for navigating aquatic habitats, despite the fundamental limitations and
Single-molecule visualisation of human Hsp70-driven conformational remodelling during stress biorxiv.org 2026-06-02 The Hsp70 chaperone system plays a central role in the folding of nascent polypeptides and in preventing protein misfolding and aggregation during cel
In-cell structures visualize human pre-ribosome assembly in the nucleolus biorxiv.org 2026-06-02 Ribosome biogenesis is an essential multi-step process.
CPAP/CENPJ is essential for the stability and function of AAA+ ATPase VPS4B biorxiv.org 2026-06-02 Function of CENPJ/CPAP is essential for centriole duplication and cilia biogenesis.
Vermeer: Autoregressive generative modeling of microscopy predicts protein localization biorxiv.org 2026-06-02 Fluorescent microscopy provides a rich view into how proteins localize within cells, but it remains experimentally infeasible to image human proteins
Protocol for assessing lysosomal ion channel function in mammalian cells using lysosomal patch-clamp technique biorxiv.org 2026-06-02 This protocol describes manual whole-endolysosome patch-clamp recordings from pharmacologically or genetically enlarged endolysosomes in cultured mamm
Prostaglandins regulate the nucleoskeleton during Drosophila border cell migration biorxiv.org 2026-06-02 The nucleoskeleton, which is comprised of Lamin A (stiffer), Lamin B, and Lamin interacting proteins, including Emerin, controls nuclear stiffness.
Maternal Gut Microbiota Regulates Neonatal Retinal Angiogenesis Through Lactational Metabolic Signalling biorxiv.org 2026-06-02 Early life vascular development is a tightly regulated process that influences organ maturation and longterm cardiometabolic and neurovascular health.
Declining autophagy drives age-related axonal decay through microtubule alterations biorxiv.org 2026-06-02 The microtubule cytoskeleton plays a pivotal role in maintaining axonal integrity, and its deterioration has been closely associated with neuronal dec
The way less obvious: PIEZO1 supports apoptotic cell extrusion by optimizing tissue mechanical tension for homeostasis. biorxiv.org 2026-06-02 Apical cell extrusion is a mechanical process that allows epithelia to eliminate apoptotic cells and prevent inflammation.
MARBL: A Live-Cell Method for Profiling Bioenergetic Heterogeneity by Noncanonical Methionine Labeling of the Cell Surface Proteome biorxiv.org 2026-06-02 Heterogeneity is a hallmark of biological systems, where cell-to-cell variability supports adaptation to changing environments, but also enables malad
HKDC1 contributes to aberrant lysosome-mitochondria contact in Niemann-Pick disease type C biorxiv.org 2026-06-02 Niemann-Pick disease type C (NPC) is a neurovisceral lysosomal storage disorder comprising two clinically indistinguishable but genetically distinct s
Synphilin-1 mitigates autophagy dysfunction, modulates ubiquitinated protein aggregation, and promotes cell survival during proteotoxic stress biorxiv.org 2026-06-02 The decline of cellular proteostasis is a hallmark of aging and key contributor to neurodegenerative diseases.
Metabolic Intervention with Dimethyl Malonate Impairs Phagocytic Clearance but Fails to Protect Neurons biorxiv.org 2026-06-02 Secondary degeneration following optic nerve crush (ONC) is driven in part by mitochondrial dysfunction and microglial activation.
A genetic model of copulatory wounding in Drosophila melanogaster biorxiv.org 2026-06-02 In the animal kingdom, copulatory wounds occur due to aggressive behavior or injury from the female or male appendages in contact.
Chaperones shape the conformational landscape of 26S-proteasome-base assembly for allosteric ATPase motor activation biorxiv.org 2026-06-02 Protein homeostasis depends on the 26S proteasome, the most complex ATP-dependent protease in eukaryotic cells.
Divergent Inclusion Body Structures and Stabilities Emerge from Native Monomer Properties biorxiv.org 2026-06-02 Protein aggregation is of broad importance in biotechnology and disease, yet the structural heterogeneity of cellular aggregates has confounded high-r
Functional coupling between the a4 - a5 loop and allosteric site on MKP5 is a critical determinant of catalysis biorxiv.org 2026-06-02 Dual-specificity phosphatases (DUSPs) that inactivate mitogen-activated protein kinases (MAPKs) are called MAPK phosphatases (MKPs).
Multimodal dynamics control activity of a glial glutamate transporter biorxiv.org 2026-06-02 Membrane transporters move polar solutes across lipid bilayers to regulate cellular metabolism, signaling, and drug distribution.
Single-Cell Electrophysiology Reveals Verapamil's Disruption of Bacterial Membrane Energetics biorxiv.org 2026-06-02 Verapamil, a clinically used calcium channel blocker, enhances the activity of several tuberculosis antibiotics, but its mechanism of action and physi
Spin-Dependent Extracellular Respiration biorxiv.org 2026-06-02 Biological energy conversion relies on highly efficient electron transfer.
Extracting anomalous diffusion parameters from multi-state ensembles of short single molecule trajectories. biorxiv.org 2026-06-02 Single-molecule tracking measures the stochastic motion of individual biomolecules in the cellular environment.