The Drosophila IR20a Integrates L-arginine and Salt Signals via Distinct Subunit Assemblies biorxiv.org 2026-06-01 Amino acids and salts are essential nutrients that frequently occur together in natural food sources.
Eyewire II - A connectomic resource for resolving cell types and circuits of the mouse retina biorxiv.org 2026-06-01 Comprehensive wiring diagrams from electron microscopy (EM) are a powerful tool to understand the inner workings of the brain.
Decoding Graded Grip-Force Intensity from fMRI Data Reveals a Transformation from Abstract to Effector- and Movement-Specific Codes prior to Execution biorxiv.org 2026-06-01 Motor planning entails a progressive transformation of neural representations - from abstract motor goals, which represent intended action-outcomes in
Characterizing variability in resting-state functional magnetic resonance imaging (rsfMRI) metrics: a normative modeling framework biorxiv.org 2026-06-01 Clinical adoption of new biomedical techniques depends on establishing reference values against which individual patients can be compared.
Opposing roles of GSDMD and NINJ1 shape early IL-1β dependent host defense during Toxoplasma gondii infection biorxiv.org 2026-06-01 Inflammasome activation is a central component of host defense against Toxoplasma gondii, yet how downstream pyroptotic effectors shape infection outc
Altered PI3K-PTEN balance promotes preferential killing of human IgE+ plasma cells by BCR crosslinking biorxiv.org 2026-06-01 Immunoglobulin E (IgE) drives allergic disease, yet what restrains the persistence of IgE production remains poorly understood.
Anti-Melanoma Differentiation-Associated protein 5 Auto-Antibodies Promote a Profibrotic Phenotype in a Human Lung Fibroblast Cell Line biorxiv.org 2026-06-01 Anti-melanoma differentiation-associated protein 5 (anti-MDA5) autoantibodies identify a distinct dermatomyositis subset frequently associated with ra
Antimicrobial activity of polymyxin A, and characterisation of the cognate biosynthetic gene cluster within the genome of the producing Paenibacillus polymyxa. biorxiv.org 2026-06-01 We report the isolation and identification of a Paenibacillus polymyxa strain from the citizen science project; Swab and Send.
Impairment of bacteriophage activity in blood: a case study revealing constraints in phage isolation and translation biorxiv.org 2026-06-01 Background Phage therapy is increasingly considered a promising alternative for treating multidrug-resistant (MDR) infections.
Scouting ecological drivers of natural enemies in citrus orchards: implications for biological control in the Corsican agricultural landscape biorxiv.org 2026-06-01 1.
Replicate-anchored calibration of within-host single nucleotide variant detection in Mycobacterium tuberculosis whole genome sequencing biorxiv.org 2026-06-01 Abstract Background.
p38 dependent IL-33 responses define a conserved inflammatory programme in mast cells biorxiv.org 2026-06-01 Interleukin-33 (IL-33) is a key cytokine in mast cell mediated immunity, promoting inflammatory cytokine production without inducing degranulation.
Heme orchestrates a tissue stress response to proteolytic damage biorxiv.org 2026-06-01 Whereas cellular stress responses are well defined, tissue-level stress remains poorly understood.
Thousandfold Expansion Microscopy biorxiv.org 2026-06-01 Biological macromolecules, such as proteins, are made of concatenated building blocks.
Overexpression of Eaf1, a subunit of the NuA4 lysine acetyl transferase complex, rescues growth defects in the budding yeast H3K36M oncohistone model via histone H4 tail acetylation biorxiv.org 2026-06-01 Histone proteins are critical for regulating functions that occur at DNA, such as gene expression.
A Foundation Model for the Cancer Genome biorxiv.org 2026-06-01 Cancer is a disease of the genome, in which somatic mutations and copy-number alterations determine tumour identity, clinical behaviour, and response
Computational Design of Two New 5-HT1B Serotonin Receptor Agonists Derived from Naratriptan biorxiv.org 2026-05-31 Migraine headaches affect over one billion people internationally and can be defined as episodes of acute severe pain wrapping around the head and are
Antibiotics and copper drive compartment-specific dysbiosis and functional reprogramming in tomato microbiomes biorxiv.org 2026-05-31 Plant-associated microbiomes help sustain plant immunity and productivity, yet the degree to which agricultural antimicrobials reshape these microbial
Comprehensive characterization of skeletal muscle remodeling in hSOD1G93A mice reveals limited functional impact of systemic FOXO1 inhibition biorxiv.org 2026-05-31 Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron (MN) loss, muscle atrop
The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa biorxiv.org 2026-05-31 Photoreceptor degeneration drives electrophysiological remodeling in downstream retinal neurons, including hyperactive firing of retinal ganglion cell
Intratumoral B7H3:CD3 Bispecific T-cell Engager Drives Localized T-cell Accumulation in Canine Sarcoma Patients biorxiv.org 2026-05-31 Background: Bispecific T-cell Engagers (TCEs) targeting B7H3 (CD276) show promise for solid tumors but are limited by systemic toxicities and poor tum
Clinical isolates of Mycobacterium avium complex reveal an M. intracellulare-associated IL-17/neutrophilic pulmonary immune program in a murine disease model biorxiv.org 2026-05-31 Mycobacterium avium complex (MAC) is the leading cause of nontuberculous mycobacterial pulmonary disease (NTM-PD) and mainly comprises M.
Organoid-T cell co-cultures functionally stratify tumor-reactive T cells and their responses to immune checkpoint inhibitors biorxiv.org 2026-05-31 Tumor-reactive T cells (TRTs) are critical for anti-tumor immunity but are incompletely captured by current assays, which fail to reproduce tumor-spec
GAPVD1 regulates CSNK1D-dependent PER2 FASP phosphorylation biorxiv.org 2026-05-31 The mammalian circadian clock relies on precisely timed transcriptional and post-translational events to generate ~24-hour rhythms.
Osteopontin Upregulation Defines a Pre-Rupture State in Thoracic Aortic Aneurysms in Mice and Humans biorxiv.org 2026-05-31 Background: Thoracic aortic aneurysm (TAA) is a life-threatening condition with an unpredictable lisk of rupture.
Detection of Pancreatic Cancer Using a Methylation-Specific PCR-Based Multi-Cancer Early Detection Test biorxiv.org 2026-05-31 Context: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy often diagnosed at advanced stages due to the lack of early clinical symp
The defining features of intrinsic transcription terminators biorxiv.org 2026-05-31 Transcription terminators are universal landmarks that delimit RNAs and tune downstream gene expression, yet the sequence rules that define them remai
Ultra-Slow Rhythmic Movement in the Elongating Tail of Xenopus Tadpoles biorxiv.org 2026-05-31 Since Darwin's time, ultra-slow oscillatory movements have been recognized as a characteristic feature of axis elongation in plant organs such as shoo
Identifying a cooperative catalytic network for efficient esterase catalysis biorxiv.org 2026-05-31 Active-site redesign frequently yields modest improvements because residues controlling physical steps like substrate binding and product release lie
LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery biorxiv.org 2026-05-31 Most human genes produce multiple RNA isoforms, yet it remains unclear which isoforms are translated into stable, functional proteins.