Macrophages reshape cytokine responses and bacterial spatial organization in an airway epithelial cell culture model biorxiv.org 2026-05-30 The increasing prevalence of antibiotic-resistant bacterial infections highlights the need for physiologically relevant in vitro models that recapitul
Rapid vaccine induction of macaque HIV-1 V2 Apex broadly neutralizing antibodies with immunogenetic signatures that are potentially translatable to humans biorxiv.org 2026-05-30 Due to the complex biology of HIV-1 broadly neutralizing antibodies (bnAbs), HIV-1 vaccines must target unmutated germline precursor antibodies with B
Structural basis for the ATP-dependence of omegasome biogenesis by DFCP1 biorxiv.org 2026-05-30 Autophagosome formation begins at phosphatidylinositol 3-phosphate-enriched endoplasmic reticulum (ER) subdomains termed omegasomes.
Cyclic voltammetry electropolymerization of PEDOT: Polydopamine on gold electrodes biorxiv.org 2026-05-30 This work presents a facile and rapid fabrication method for high-performance bioelectrode coatings through electropolymerization of poly(3,4-ethylene
A Sandwich-Structured Silk Fibroin Mesh with ROS-Responsive and Immunoregulatory Functions for Pelvic Floor Repair biorxiv.org 2026-05-30 Current biodegradable meshes for pelvic floor repair are constrained by a limited ability to actively modulate the hostile immune microenvironment fol
Information-Theoretic Functional Connectivity Characterizes Multiscale Network Reorganization in Postoperative Cognitive Decline biorxiv.org 2026-05-30 Postoperative cognitive decline (POCD) after coronary artery bypass grafting (CABG) is increasingly conceptualized as a system-level disturbance of la
Drug Affinity and Functionalization of Gold Nanoparticles: AFMSEIRA and SERS Study biorxiv.org 2026-05-30 This study presents the first investigation of the adsorption behaviour of Afatinib on gold nanoparticle (AuNP) monolayers, employing a combination of
Design-space requirements for abundance-amplified drug-like targeting of RHSVV/PAb240-like p53 exposure in TP53-mutant cancer biorxiv.org 2026-05-30 TP53-mutant cancers often accumulate p53 protein, creating a potential abundance-amplified therapeutic target, but wild-type p53 can also rise in stre
Growth-resolved genome-scale metabolic modeling of Priestia megaterium SR7 validated by chemostat and 13-C flux analysis biorxiv.org 2026-05-30 Priestia megaterium SR7 is a promising candidate chassis for bioprocess engineering, but its development is limited by the availability of condition-g
Intestinal Dysbiosis in Necrotic Enteritis: Dissecting the Roles of Eimeria and Clostridium perfringens biorxiv.org 2026-05-30 Necrotic enteritis (NE), caused by Clostridium perfringens, is major enteric disease in poultry with substantial economic impact.
The Neurodynamic Core of Meditation: Dissociating Meditation from Rest and Task in a Reliability-based EEG study biorxiv.org 2026-05-30 Background: Electroencephalographic (EEG) studies attempting to characterise the neural signature of meditation typically rely on contrasts with passi
Pathogenic MYBPC3 missense variants alter protein-protein interactions within the sarcomere biorxiv.org 2026-05-30 Aims: Hypertrophic cardiomyopathy (HCM) is a genetic heart disease that leads to left ventricular hypertrophy, heart failure, and arrhythmias.
The TCA cycle and pentose phosphate pathway are linked to lipid droplet expansion in nitrogen-starved Lipomyces starkeyi cells biorxiv.org 2026-05-30 In eukaryotic cells, lipid droplets (LDs) play critical roles in storing energy, preventing lipotoxicity, promoting membrane biogenesis, and regulatin
Alveolar niche disruption and aberrant epithelial reprogramming are early hallmarks of idiopathic pulmonary fibrosis biorxiv.org 2026-05-30 Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which the earliest cellular events driving fibrosis remain poorly de
Structure and Variation in Dam-Daughter Bonds in Captive Rhesus Macaques biorxiv.org 2026-05-30 Mother-daughter relationships are central to social organization in rhesus macaques, providing the foundation for kin familiarity, affiliative bias, a
Monitoring Sphingomyelin Biosynthesis at Nanoscale Resolution by Expansion Microscopy biorxiv.org 2026-05-30 Sphingomyelin is the most abundant sphingolipid in mammalian cells and is synthesized by two isoenzymes, sphingomyelin synthase 1 and 2, located in th
reComBat-seq: Regularized negative binomial regression for batch-effect correction in underdetermined transcriptomics datasets biorxiv.org 2026-05-30 Motivation: Batch effect correction is essential for the integration of large-scale transcriptomics datasets such as single-cell RNA-seq or multi-stud
SpatialDataAgent: Autonomous Spatial Omics Data Curation at Decade Scale biorxiv.org 2026-05-30 Fragmented metadata in spatial omics archives has rendered large volumes of multimodal molecular-histological data inaccessible as 'dark data'.
Differential Induction of Cancer Cell Death by Root, Leaf, and Flower Extracts derived from Kalanchoe pinnata biorxiv.org 2026-05-30 Kalanchoe pinnata is a perennial plant that grows wild in tropical regions and is traditionally used as a medicinal plant.
Genome editing of key domestication genes overcomes self-incompatibility and bitter taste in cultivated buckwheat biorxiv.org 2026-05-30 Buckwheat (Fagopyrum spp.) is a climate-resilient pseudocereal, yet its global adoption is constrained by the distylous self-incompatibility of common
EndoTwin-W: glycodelin-A and CA-125 as non-invasive biomarkers of endometrial receptivity derived from a multiscale computational digital twin biorxiv.org 2026-05-30 Endometrial receptivity assessment currently requires invasive tissue biopsy, yet recent randomized trials have questioned the clinical utility of bio
Epidermal microstructure and tactile sensitivity in the glabrous skin of hands and feet biorxiv.org 2026-05-30 Glabrous skin on the human palms and soles is specialised for mechanical interaction and is characterised by papillary ridges, an absence of hair foll
Task-Dependent Modulation of Feedback Control in Human Steering biorxiv.org 2026-05-30 We examined whether human steering behavior conforms to optimal feedback control (OFC) principles when driving a vehicle through sequences of upcoming
Molecular Basis of Histone H3 Reading and Writing by Legionella pneumophila SET Domain Lysine Methyltransferases biorxiv.org 2026-05-30 RomA and its highly conserved strain ortholog LegAS4 are SET and ankyrin domain-containing effector proteins of the intracellular bacterial pathogen L
Structural Connectivity Between the Zinc Linchpin Motif, the cluster, and the active site orchestrates DNA repair in MUTYH biorxiv.org 2026-05-30 The DNA glycosylase MUTYH protects genomic integrity by excising adenine mispaired with 8-oxoguanine (OG), which initiates base excision repair (BER).
Super-resolution complexome of human mitochondria elucidates translocase, morphology and OXPHOS networks biorxiv.org 2026-05-30 Mitochondria function as cellular powerhouses and central hubs in metabolism, redox and stress reactions, signaling and apoptosis.
BasalCell: A project scaffold generator for bioinformatics analysis biorxiv.org 2026-05-30 In the current bioinformatics landscape, where R-centric and Python-centric ecosystems coexist and overlap, there is an increasing demand for the orga
Genotype and methylation interact to reconfigure transcriptional regulation in colorectal cancer biorxiv.org 2026-05-30 Background Transcriptional regulation is shaped by both genomic variants and the environment.
Personalized reference genome-based pipeline reveals comprehensive haplotype-resolved views of cancer genomes biorxiv.org 2026-05-30 Cancer genome analysis relies on standard human reference genomes but detecting somatic alterations in highly repetitive or individual-specific region
Deformation Gradient Tensor Model of Roll-Spiral Transformation for Protein Assembly Refractile Body biorxiv.org 2026-05-30 Spiral geometries commonly occur in natural and engineered systems and are fundamentally described by curvature and torsion.