A new skeleton of the gorgonopsian Aelurognathus tigriceps from the Daptocephalus Assemblage Zone (Karoo Basin, South Africa) with novel insights into the pelvic girdle, hind limbs, and tail biorxiv.org 2026-05-30 Gorgonopsian therapsids represent a transitional condition in the evolution of synapsid locomotion and postcranial structure.
Ontology-driven software engineering using LLMs for knowledge graphs in engineering biology biorxiv.org 2026-05-30 Large language models have transformed software engineering practices.
Rapid Isothermal Detection of Heavy Metals via Transcription-Factor-Gated DNA Strand Synthesis biorxiv.org 2026-05-30 Conventional methods for monitoring toxic heavy metals typically require sophisticated laboratory instrumentation and leave a critical gap for rapid,
Ultrasensitive response in bacterial replication initiation biorxiv.org 2026-05-30 Bacteria are able to coordinate cell growth and genome replication in different growth conditions.The DNA-binding protein DnaA is responsible for dete
Modeling of Glucosinolate Biosynthesis During Biotic Stress as a Function of mRNA biorxiv.org 2026-05-30 Glucosinolates are an important group of specialized metabolites in the Brassicaceae family, playing a role as defensive compounds against biotic atta
Functional Characterization of RSV Clades Associated with Prophylactic Breakthrough Infections in Pediatric Transmission Clusters biorxiv.org 2026-05-30 The recent development of new respiratory syncytial virus (RSV) prophylactics for the prevention of severe lower respiratory tract infections in infan
Establishing the fluorescence-activating and absorption-shifting tag as a fluorescent reporter protein in Methanothermobacter thermautotrophicus ΔH biorxiv.org 2026-05-30 The thermophilic methanogen Methanothermobacter thermautotrophicus {Delta}H is a model microbe for hydrogenotrophic methanogenesis and an emerging pla
Microbial exometabolite responses to root exudates from tallgrass prairie plants biorxiv.org 2026-05-30 Root exudates influence soil microbial community assembly and function, yet plant species-specific effects on microbially-driven metabolic transformat
A new reference-invariant consensus template generation method in ALPACA biorxiv.org 2026-05-30 1. Automated landmarking transfers anatomical landmarks from a reference specimen onto many targets, greatly increasing analytical throughput.
Development shapes molecular responses to thermal extremes in a desert bird biorxiv.org 2026-05-30 Thermal extremes are among the most immediate environmental challenges faced by animals.
Buffering of developmental noise provides a mechanism for heterosis in both polyploid and diploid hybrids biorxiv.org 2026-05-30 Using an abstract computational model of multicellular development, I show that the deleterious effects of gene expression noise on development are he
Characterizing the Molecular Determinants of Clamp Binding in B. subtilis biorxiv.org 2026-05-30 In bacteria, the ring-shaped sliding clamp, DnaN, is an essential component of the replication machinery.
Candida albicans reprograms host inosine metabolism to drive immunosuppressive macrophage polarization and gastric cancer carcinogenesis biorxiv.org 2026-05-30 Gastric cancer (GC) is strongly associated with changes in the gastric microbiome.
Explainable machine learning reveals an RBP regulatory logic of exon skipping biorxiv.org 2026-05-30 RNA binding proteins (RBPs) regulate the life cycle of an mRNA, often through RBP-RNA interactions.
The b0+ Amino Acid Transporter Defines a Selenium-utilization Enterocyte Program in the Human Intestine biorxiv.org 2026-05-30 Selenium is an essential trace element incorporated into selenoproteins as selenocysteine, yet the intestinal cellular programs associated with seleni
PAIR-link: a ligation-free strategy that joins two RNAs into a single sequence-preserving chimeric cDNA biorxiv.org 2026-05-30 Physical proximity between RNA molecules, and between the proteins that bind them, underlies much of post-transcriptional regulation, yet the methods
A pilot assessment of avian communities and soundscapes along an Amazonian fluvial corridor biorxiv.org 2026-05-30 Quantifying biodiversity patterns in remote Amazonian ecosystems remains constrained by the limitations of traditional field surveys.
Elementary Dynamics of Neural Microcircuits biorxiv.org 2026-05-31 Interactions between distinct populations of excitatory (E) and inhibitory (I) neurons can produce complex dynamical landscapes, featuring multistabil
Ultrasensitive voltage imaging reveals distinct electrical microdomains in neurons biorxiv.org 2026-05-31 For the brain to compute, electrical signals must propagate over the membranes of individual neurons, connecting synaptic inputs to synaptic outputs.
A hierarchical Bayesian framework accommodates intraspecific and interspecific variation in multivariate traits biorxiv.org 2026-05-31 Phylogenetic comparative methods are a critical tool in biology, providing the framework to test evolutionary hypotheses of phenotypic diversification
Accounting for recurrent mutation in the frequency spectrum of rare alleles biorxiv.org 2026-05-31 As whole-genome and whole-exome datasets increase in size, they uncover alleles at lower and lower frequencies in the population.
TEX15 safeguards neuronal diversity in the mouse olfactory system biorxiv.org 2026-05-30 Animal chemosensory systems discriminate between complex mixtures of chemical compounds by leveraging large repertoires of chemoreceptor proteins.
Hippocampal and prefrontal contributions to memory-guided navigation depend on task epoch biorxiv.org 2026-05-31 The hippocampus and medial prefrontal cortex (mPFC) are required for delayed working-memory tasks, but when in the task their engagement becomes neces
Early reaction time variability predicts implicit statistical learning: a comparison of four variability indices biorxiv.org 2026-05-31 High intra-individual reaction time variability (RTV) is traditionally viewed through a deficit perspective and interpreted as a maladaptive signature
Category-selective functional connectivity during episodic encoding and retrieval in younger and older adults biorxiv.org 2026-05-31 Regions within ventral occipito-temporal cortex exhibit category-selective BOLD responses during episodic encoding and retrieval of visual information
Olfactory learning potentiates long-range cortical GABAergic inputs onto adult-born neurons. biorxiv.org 2026-05-31 Adult neurogenesis in the olfactory bulb (OB) contributes to structural and functional plasticity, influencing olfactory perception, learning, and mem
Relative Hemodynamic Timing in Human White Matter biorxiv.org 2026-05-31 Hemodynamic lag in white matter (WM) remains poorly understood despite its relevance to neurovascular health.
Chronic Mild Stress Impairs Hippocampal Myelination through SOX6-Dependent Dysfunction of Oligodendrocyte Lineage Cells biorxiv.org 2026-05-31 Chronic stress induces structural and functional changes in the brain, increasing susceptibility to major depressive disorder and other mental illness
PCO371 intracellular agonism at the parathyroid hormone 1 receptor produces pan-activation of signalling partners biorxiv.org 2026-05-30 Small-molecule agonists of class B1 G-protein-coupled receptors (GPCRs) remain rare because these receptors typically require large extracellular pept
HARP: Hierarchical Anatomical Refinement of Pathways for Whole-Brain Tractography biorxiv.org 2026-05-30 Diffusion MRI tractography is an ill-posed inverse problem that requires anatomical constraints to ensure the plausibility of reconstructed white-matt