Instance-Wise Contrastive Graph Neural Network Enables the Discovery of Novel Aedes aegypti Larvicidal Compounds biorxiv.org 2026-05-31 Aedes aegypti remains a major arboviral vector, making larval control a critical strategy to reduce mosquito populations.
Analytical Choices Drive Toxicogenomic Potency Estimates: A Systematic Evaluation of Transcriptomic Points of Departure biorxiv.org 2026-05-31 Omics technologies are increasingly integrated into next-generation risk assessment, yet quantitative toxicogenomics outcomes remain highly dependent
Decoding Hierarchical Cell-Cell Communication in Spatial Multi-Omics with CellSTIC biorxiv.org 2026-05-31 Cell-cell communication helps to coordinate tissue development, homeostasis, and immune responses, but identifying signaling interactions within intac
Antibody maturation increases rigidity in protein-contacting regions and flexibility at glycan interfaces biorxiv.org 2026-05-31 Antibody design is a challenging task that could be improved by understanding the conformational changes accompanying affinity maturation.
Auranofin potentiates cisplatin response through context-dependent NOTCH-associated signaling states in endometrial cancer biorxiv.org 2026-05-31 Therapeutic resistance remains a major challenge in advanced and recurrent endometrial cancer (EC).
Matched pancreatic cancer liver metastatic model system reveals cancer cell-dependent organotropism and site-specific tumor microenvironment reflective of human disease biorxiv.org 2026-05-31 Pancreatic ductal adenocarcinoma (PDAC) is a deadly, highly metastatic disease, driven by an interplay between cancer cells and the metastatic site-sp
Gut Microbiota Dysbiosis Drives Myocardial Hypertrophy Through GBP2b/GBP1-Mediated Immune Reprogramming and Exosomal Signaling in Chronic Colitis biorxiv.org 2026-05-31 BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk of cardiovascular disease, yet the mechanisms linking chronic intesti
Trichome acylsugar defenses are equally effective against leaf-mining and free-living insects biorxiv.org 2026-05-31 Trichomes are epidermal projections, crucial components of plant defense systems.
Diel metabolic plasticity of CAM photosynthesis in MD-2 pineapple (Ananas comosus) under contrasting tropical environments: biochemical patterns and agronomic implications. biorxiv.org 2026-05-31 Abstract The current understanding of Crassulacean Acid Metabolism (CAM), including semi-controlled studies in pineapple, does not fully explain outco
Context-dependent modulation of social space by dopamine receptors in the Drosophila melanogaster mushroom body biorxiv.org 2026-05-31 Social behavior takes many forms, yet the fundamental principles of social circuit function are thought to be evolutionarily conserved.
Talin-1 determines the direction of primary mouse neutrophils migrating in vivo biorxiv.org 2026-05-31 Talin-1 is essential for {beta}2 integrin activation in neutrophils, yet its dynamic behavior during neutrophil trafficking in vivo remains poorly und
SCD-dependent lipid metabolism licenses alternative macrophage activation and macrophage plasticity biorxiv.org 2026-05-31 Lipid metabolic reprogramming accompanies macrophage activation, yet our understanding of why macrophages profoundly reshape their lipid composition r
Elamipretide reverses female fertility decline during reproductive aging via regulating VEGF in oocytes biorxiv.org 2026-05-31 Aging is one of the primary drivers for the decline of female fertility, and oocyte quality is the main cause for ovary aging, which is related with i
Brain and neuronal expression and localization of de-S-acylating enzymes biorxiv.org 2026-05-31 S-acylation is a reversible posttranslational lipid modification important in the nervous system that dynamically regulates protein localization and f
A Na⁺-PINK1 signaling axis couples mitochondrial fission to structural remodeling during synaptic depression biorxiv.org 2026-05-31 Mitochondrial density in dendrites adapts to the number of synaptic inputs to adequately sustain local ATP and Ca2+ buffering for neuronal signaling.
Neurofeedback enhances a neural signature of selective attention to speech in cocktail-party settings biorxiv.org 2026-05-31 Understanding speech in noisy situations is challenging and often fails due to attentional rather than sensory deficits.
A conserved mechanism for regulation of mtDNA copy number in eukaryotes biorxiv.org 2026-05-31 Mitochondrial mass and mitochondrial DNA (mtDNA) copy number are coupled to metabolic demand at the cellular, tissue and organismal level, however, th
Regulatory architecture controlling terminal differentiation of an interoceptive paraneuron in C. elegans biorxiv.org 2026-05-31 Interoceptive paraneurons are neuron-like cells located within internal epithelial cell surfaces that sense internal stimuli to evoke specific behavio
Shared binding sites for the chromosomal architectural protein Su(Hw) mediate physical interactions between Drosophila TAD boundaries biorxiv.org 2026-05-31 Loop extrusion has been clearly shown to be insufficient as a mechanism to explain TAD formation, leaving a large gap in our understanding of how the
Rare RNA Polymerase II failure modes mark the cancer-driving genes most affected by epigenetic perturbation biorxiv.org 2026-05-31 RNA Polymerase II (Pol2) transcribes genes through a complex life cycle (initiation, pausing, elongation, co-transcriptional splicing, termination, an
Ceramide Synthases Regulate Myristate-Induced Intestinal IRE1α Activation biorxiv.org 2026-05-31 Background & Aims: High-fat diets (HFDs) are a major modifiable risk factor for intestinal health.
The UPR drives gametogenesis via an unexpected response, coordinating translation and ER structure biorxiv.org 2026-05-31 Stress responses, including the unfolded protein response (UPR), are commonly studied via induction with harsh exogenous stressors, leaving endogenous
iSsus3744: A Genome-Scale Model-Guided Strategy for Rational Media Design for Cultivated Pork biorxiv.org 2026-05-31 Cultivated meat production is currently limited by high production costs and an incomplete understanding of cellular metabolism in agriculturally rele
Expanded Proteome Coverage Powered by Advanced Ion Processing Enables Deep Single-Cell Drug Response Subtyping in Human Stem Cell Derived Cardiomyocytes biorxiv.org 2026-05-31 Single-cell proteomics (SCP) enables the study of cellular heterogeneity at the functional level but remains limited by incomplete proteome coverage a
S-nitrosylation of protein kinase A is required for its activation by GPCRs biorxiv.org 2026-05-31 Stimulation of many G protein-coupled receptors (GPCRs) increases cyclic adenosine monophosphate (cAMP) and nitric oxide (NO).
Proteomic analysis of human leptomeningeal matrisome identifies changes in Alzheimer's disease biorxiv.org 2026-05-31 The leptomeninges (arachnoid and pia) are the inner layers of the meninges that envelope the brain.
O-GlcNAc transferase regulates H2O2 production via p38 MAPK biorxiv.org 2026-05-31 Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by augmented transforming growth factor-{beta} (TGF-{beta
A Toxic Tau-PFKFB3 Circuit Reduces F2,6BP Levels and Drives Neurodegeneration biorxiv.org 2026-05-31 Alzheimer's disease (AD) and related dementias are progressive neurodegenerative disorders manifested by aggregation of Tau and Amyloid beta (A{beta})
Paraventricular thalamus gates hippocampal coding of salient experiences. biorxiv.org 2026-05-31 Adaptive behavior requires neural circuits that encode salient stimuli to guide approach and avoidance.
Developmental genetic response of the zooplanktonic tunicate Oikopleura dioica to marine noise pollution. biorxiv.org 2026-05-31 Background: Anthropogenic noise is an emerging threat to marine ecosystems, yet its effects on marine invertebrates, particularly zooplanktonic specie