Bayesian optimisation and graph-based rheology enable sequence-dependent modelling of DNA materials biorxiv.org 2026-05-30 Bridging molecular and emergent properties is essential for designing soft matter.
Amplicon/Protein Bead Display enables quantitative in vitro biochemistry at scale biorxiv.org 2026-05-30 Scalable methods for producing and characterizing protein libraries are essential for generating standardized datasets needed to train models linking
Disentangling RNA evolution and thermodynamics in genomic language models biorxiv.org 2026-05-30 Genomic language models (gLMs) trained only on large-scale nucleic acid sequence data seem to capture signals of RNA structure, yet the specifics of h
Age and Gender-Dependent Group-Average Brain Biomechanics Models for Traumatic Brain Injury biorxiv.org 2026-05-30 Experimental studies involving mechanical loading of the human head and brain in vivo are necessarily limited, making computational modeling essential
Quantum transport in mitochondrial complex I is governed by a conserved structural bottleneck biorxiv.org 2026-05-30 Electron transport in mitochondrial complex I is mediated by a chain of redox centers, yet how electrons traverse this network beyond the canonical pa
TIAR-dependent coordination of alternative splicing and lipid peroxidation is required for CML cell resistance to imatinib in the bone marrow stroma biorxiv.org 2026-05-30 Tyrosine kinase inhibitors (TKIs) are the first-line therapy for chronic myeloid leukemia (CML), yet fail to eliminate quiescent CML cells residing in
Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung Fibrosis biorxiv.org 2026-05-30 Idiopathic pulmonary fibrosis (IPF) is characterized by failed alveolar epithelial repair and progressive fibrotic remodeling.
Tetramerization and RNA-guided filament assembly control Schlafen-Argonaute antiphage defense biorxiv.org 2026-05-30 Two deeply conserved protein families, Argonaute (Ago) and Schlafen (SLFN), play defense roles in diverse prokaryotes and eukaryotes, including humans
TgmRHel drives unified RNA processing of coxI mRNA generated from a complex mitochondrial genomic context biorxiv.org 2026-05-30 The mitochondrial genome of Toxoplasma gondii is highly fragmented and recombination-prone, creating a structurally dynamic genetic landscape.
Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation biorxiv.org 2026-05-30 Insulinomas are rare and benign human pancreatic adenomas that overproduce insulin and display increased beta cell mass.
Cooperative FOXA1-HNF4A binding emerges from motif spacing and nucleosome architecture biorxiv.org 2026-05-30 The pioneer factor hypothesis posits that specialized transcription factors access nucleosomal DNA to enable binding of secondary factors, implying a
Ultra-low biomass sequencing workflow (LBV-Seq) enables de novo metagenomic reconstruction of DNA and RNA viral genomes biorxiv.org 2026-05-30 Genome-resolved virome analysis remains inaccessible for many samples, including those with clinical relevance, because viral nucleic acid recovered a
Fragmentation Patterns of Human Telomeric Chromatin in Plasma cfDNA biorxiv.org 2026-05-30 The unique chromatin structure at telomeres protects the linear ends of chromosomes from DNA surveillance machineries.
Drought Dominates Engineered Lipid Sink Effects on Sorghum Physiology and Carbon Allocation biorxiv.org 2026-05-30 Determining the environmental limits that govern how engineered metabolic traits control whole-plant carbon (C) allocation is essential for developing
Soundscape reflects breeding phenology in colonial seabirds biorxiv.org 2026-05-30 Migratory seabirds are valuable indicators of marine ecosystem change but can be difficult to monitor during the breeding season due to dense colonies
Structure can emerge from disorder under neutral evolution biorxiv.org 2026-05-30 Mutations are often thought to destabilize protein structures.
Allele-specific expression reveals complex cis- and trans-regulatory divergence underlying fruit phenotypic differences between cultivated and wild tomato species biorxiv.org 2026-05-30 Tomato (Solanum lycopersicum) is one of the most important agricultural crops and serves as a model system for fleshy fruit biology.
Local Temperature and Humidity are Associated with Proportion of Antimicrobial-Resistant Escherichia coli isolates in Farm Environments: Considerations for On-Farm Surveillance biorxiv.org 2026-05-30 Evidence suggests that increased local temperatures are associated with higher prevalence of antimicrobial resistance (AMR) in environmental bacteria.
Supplemental deinoxanthin ameliorates bone marrow microenvironmental impairments and recovers functional damage of bone marrow-retained cells in total body irradiation-exposed mice biorxiv.org 2026-05-30 Total body irradiation (TBI) can impair the bone marrow (BM) microenvironment and dysregulate the fates of BM-residing cells by overproducing reactive
Vorinostat (SAHA) alters the skeletal muscle differentiation program biorxiv.org 2026-05-30 Epigenetic regulation, particularly histone acetylation, plays a critical role in skeletal muscle differentiation by modulating gene expression progra
Colchicine Directly Targets Aldehyde Dehydrogenase 2 (ALDH2) to Suppress Radiation-Induced Senescence and Atherosclerosis biorxiv.org 2026-05-30 Background: Ionizing radiation (IR) accelerates atherosclerosis through induction of cellular senescence, DNA damage, defective efferocytosis, and dys
Glucocorticoid Programming of Erythrocyte Hypoxic Memory Enables Rapid High-Altitude Acclimatization biorxiv.org 2026-05-30 Background: Rapid ascent to high altitude causes acute mountain sickness (AMS) and life-threatening pulmonary/cerebral edema, yet no prophylaxis enabl
PCP-dependent polarity propagation across neuronal columns in the Drosophila medulla biorxiv.org 2026-05-30 Planar cell polarity (PCP) signaling establishes coordinated tissue polarity through asymmetric localization of core PCP factors and propagation of po
Bartonella and hemotropic Mycoplasma species in synanthropic bats in Kenya biorxiv.org 2026-05-30 Identifying and characterizing zoonotic pathogens in wildlife is essential for understanding disease risk to humans.
Vegetation and fires under climate change: a Mediterranean modelled case study from central Italy biorxiv.org 2026-05-30 Wildfire regimes in Mediterranean landscapes are undergoing significant changes due to the combined effects of land-use transitions and climate change
Fiat lux: A hotspot of Luciola fireflies on Western Mediterranean islands biorxiv.org 2026-05-30 Islands are priority areas for the study and conservation of biodiversity, as they frequently harbour distinct lineages.
Top-down and bottom-up landscape processes influence the formation of microbial partnerships in herbivorous insects biorxiv.org 2026-05-30 Many insects form intimate associations with microbial partners, spanning a continuum from obligate mutualisms to transient associations.
Unifying coexistence theory for ecological communities and pathogen strain competition biorxiv.org 2026-05-30 Predicting the outcome of species or pathogen strain competition is a fundamental aim in both community ecology and infectious disease dynamics.
Advancing Great Lakes Coastal Wetland Food Web Models Using an Integrative Tracer Approach biorxiv.org 2026-05-30 Coastal wetlands of the Laurentian Great Lakes support abundant populations of fish, invertebrates, and vegetation, though the trophic linkages connec
Bayesian optimal designs for common single-driver experiments in ecology biorxiv.org 2026-05-30 When measuring the impact of continuous independent variables, regressions are the appropriate tool.