Identification of genes important for response of Pseudomonas aeruginosa biofilms to ciprofloxacin exposure biorxiv.org 2026-05-29 Pseudomonas aeruginosa is an opportunistic pathogen that can cause severe infections in immunocompromised individuals, such as patients with cystic fi
Life-history traits may buffer genetic erosion under isolation in mountain sky-island systems biorxiv.org 2026-05-29 Sky-island systems provide natural case studies for understanding how geography and Quaternary history shape genomes, phenotypes and life-history trai
Programmable DNA integration with New-to-Nature tools using Computational Protein Design biorxiv.org 2026-05-29 Programmable integration of large DNA cargo ([≥] 2 kb), without inducing double-strand breaks, remains challenging for genome editing technologies.
Single-cell analysis of human embryos reveals diverse patterns of aneuploidy and mosaicism biorxiv.org
A multi-omics genome-and-transcriptome single-cell atlas of human preimplantation embryogenesis reveals the cellular and molecular impact of chromosome instability biorxiv.org
Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells biorxiv.org
Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis biorxiv.org
Stem cell-derived mouse embryos develop within an extra-embryonic yolk sac to form anterior brain regions and a beating heart biorxiv.org
Multiplex profiling of developmental enhancers with quantitative, single-cell expression reporters biorxiv.org
Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous ECM biorxiv.org
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids biorxiv.org
Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation biorxiv.org
Induction and <i>in silico</i> staging of human gastruloids with neural tube, segmented somites & advanced cell types biorxiv.org
In toto analysis of multicellular arrangement reduces embryonic tissue diversity to two archetypes that require specific cadherin expression biorxiv.org
Self-organization of embryonic stem cells into a reproducible embryo model through epigenome editing biorxiv.org
Challenging the Astral <sup>™</sup> mass analyzer - up to 5300 proteins per single-cell at unseen quantitative accuracy to study cellular heterogeneity biorxiv.org
Transgene-Free Ex Utero Derivation of A Human Post-Implantation Embryo Model Solely from Genetically Unmodified Naïve PSCs biorxiv.org
Reconstituting epiblast–extraembryonic endoderm interactions restores anterior–ventral patterning in mouse stem cell–based embryo models biorxiv.org