Gaze information enhances remote skill transfer of piano performance biorxiv.org 2026-05-29 Remote instruction is increasingly used to teach complex sensorimotor skills, yet conventional audio-video communication poorly conveys the fine-grain
Temporal structure of task engagement organizes infra-slow BOLD dynamics biorxiv.org 2026-05-29 Task-based fMRI has traditionally characterized cognitive engagement through spatial patterns of BOLD activation, leaving less understood whether task
Soma-seq links intracellular protein states to transcriptional programs in the human brain biorxiv.org 2026-05-29 Neurodegenerative disease is largely driven by pathological protein states, which cannot be fully inferred from transcript levels.
Prevention of mRNA vaccine-induced anaphylaxis by peripheral cyclooxygenase inhibitors in an anti-PEG hyperimmune pig model: clinical relevance for nanomedicine-induced infusion reactions biorxiv.org 2026-05-29 Anti-polyethylene glycol (PEG) hyperimmune pigs, immunized against PEG, provide a sensitive experimental model for the rare anaphylactic reactions ind
Southeastern Australian Montane Fens Harbour Distinct Microbial Communities Rich in Novel Diversity biorxiv.org 2026-05-29 Montane fens are rare and microbiologically poorly characterised wetland ecosystems in south-eastern Australia, and their microbial communities remain
Fermented Botanical Product Modulates Soil Bacterial Communities and Enhances Plant-Growth-Promoting Activity for Sustainable Agriculture biorxiv.org 2026-05-29 Although biostimulants have attracted attention for sustainable agricultural systems, their efficacy remains poorly understood.
Tripartite synergy - Metabolic crosstalk between two bacterial mutualists and a marine microalga promotes algal fitness biorxiv.org 2026-05-29 Marine microalgae form major parts of phytoplankton and are highly relevant for global CO2 fixation.
Delivery of defective interfering RNA antivirals to the lungs using hyperbranched poly(beta-amino ester) nanoparticles biorxiv.org 2026-05-29 Hyperbranched poly(beta-amino ester) (hPBAE) nanoparticles represent a promising platform for nucleic acid delivery, particularly to the lungs.
Structural basis for recognition of a gonococcal lipooligosaccharide epitope by monoclonal antibody 2C7 informs vaccine and immunotherapeutic design biorxiv.org 2026-05-29 Neisseria gonorrhoeae causes gonorrhea and poses a growing global health threat driven by antimicrobial resistance and the lack of an effective vaccin
Feeding-mode-defined microbial communities modulate prebiotic responses and alters colonic motility in early life biorxiv.org 2026-05-29 Prebiotic supplementation a well-established impact on early-life gut microbiota, yet how substrate type and baseline community structure interact to
Genome-resolved metagenomics reveals the potential for selection for antibiotic resistance due to metal pollution in soil microbial communities near a copper-nickel mine site in Botswana biorxiv.org 2026-05-29 Mismanagement and metal pollution are high in countries in the global south and often create challenging, extreme conditions for soil microbial commun
TDP1 drives MRE11-dependent and independent end resection during replication stress by TOP2 poisons biorxiv.org 2026-05-29 DNA-Topoisomerase crosslinks are lesions formed by proteins covalently bound to DNA, and these complexes directly impede transcription and replication
Quantifying circulation and antibody cross-reactivity for co-circulating flaviviruses: the case of Usutu and West Nile virus in blackbirds biorxiv.org 2026-05-29 Serological testing is important for assessing past exposure and immunity, but interpretation can be complicated by antibody cross-reactivity between
Development of a CRISPR/Cas9-mediated transformation procedure for the wheat pathogen Zymoseptoria tritici biorxiv.org 2026-05-29 Zymoseptoria tritici is the causal agent of Septoria tritici blotch (STB), one of the most destructive diseases of wheat worldwide. Although the Z.
Mutational and functional heterogeneity of homology-directed repair deficiency and clinical implications biorxiv.org 2026-05-29 Homology-directed repair deficiency (HRd) encompasses mutations in multiple genes yet is treated clinically as a single entity.
Graph-based pangenome provides insights into the adaptive evolution of Cucurbita pepo biorxiv.org 2026-05-29 Understanding how crops respond to environmental variation is crucial for biodiversity conservation and food security.
An SE(3)-equivariant Crystal Structure Prediction Framework for Prospective Identification and Development of Bioactive Nucleoside Self-Assembling Materials biorxiv.org 2026-05-29 Flexible organic small molecules can assemble into functional materials whose properties are intrinsically governed by their crystal structures, yet e
NEO-AAV: an engineered extracellular vesicle-enveloped AAV platform for activation-coupled T cell transduction and CAR-T cell generation biorxiv.org 2026-05-29 Efficient and targeted delivery of genetic cargo remains a major barrier for gene and cell therapies, particularly in primary human T cells that are i
Computational Structure Modeling, Functional Characterization, and Identification of Potential Inhibitors for the cyclic-di-GMP Mediated Biofilm Forming Membrane Protein in Vibrio cholerae biorxiv.org 2026-05-29 Cholera, caused by Vibrio cholerae, continues to pose a serious global public health challenge, with its impact worsened by rising antibiotic resistan
Solvent ordering in a fully packaged RNA bacteriophage and the mechanics of genome delivery biorxiv.org 2026-05-29 Self-assembly of an RNA virus requires a thermodynamic state stable enough to confine the highly charged genome yet primed for genome delivery.
DeepDiffusion: a Physics-Informed Neural Network for Heterogeneous Facilitated 1D Diffusion biorxiv.org 2026-05-29 Single-molecule fluorescence microscopy combined with optical tweezers has enabled the direct observation of diffusing proteins on tethered DNA.
Bright Probes, Blurred Metabolism: Navigating Fluorescent Protein Cross-Excitation in NADH FLIM biorxiv.org 2026-05-29 Fluorescence lifetime imaging microscopy (FLIM) of endogenous NAD(P)H enables the label-free assessment of cellular metabolic state.
Inhibition of hexokinase 2 undermines cartilage health and accelerates osteoarthritis biorxiv.org 2026-05-29 Objective: Enhanced glycolysis is a metabolic hallmark of chondrocytes in osteoarthritis (OA); however, the roles of the glycolytic rate-limiting enzy
Synthetic cell-cell adhesion provides benefits of proximity without diffusion-related costs biorxiv.org 2026-05-29 Multicellularity provides many advantages over unicellularity, but accessing those benefits with synthetic biology approaches is challenging due to po
The mechanosensitive channel MscS links lipoteichoic acid synthesis alterations to beta-lactam sensitivity in Staphylococcus aureus biorxiv.org 2026-05-29 Lipoteichoic acid is an essential cell envelope polymer in Staphylococcus aureus and contributes to beta-lactam resistance in methicillin-resistant S.
A 667-nucleotide sequence in the SARS-CoV-2 nsp15 coding region promotes genome encapsidation biorxiv.org 2026-05-29 Coronavirus genome encapsidation depends on cis-acting RNA elements that interact with viral structural proteins.
Phenological Plasticity without Directional Change: Tropical Hornbills Track Temperature but Maintain Reproductive Stability biorxiv.org 2026-05-29 Climate change is altering breeding phenology in birds worldwide, yet tropical systems remain understudied despite harbouring the greatest avian diver
Multispecies Mixtures: An Individual-Centered Quantitative Genetic Framework for Complex Plant Neighborhoods biorxiv.org 2026-05-29 Modern agriculture faces major sustainability challenges, including stagnating yields, dependence on fossil resources, and severe environmental impact
Decoding universal principles of codon-mediated regulation of gene expression biorxiv.org 2026-05-29 Codon usage determines gene expression levels, yet its universal principles remain elusive.
High-Dimensional Sensitivity Analysis for Genomic Studies: An Adversarial Framework for Learning Worst-Case Latent Confounders biorxiv.org 2026-05-29 High-dimensional genomics studies are frequently confounded by unmeasured biological processes that obscure disease-specific signals.