Beyond ex vivo and in vivo CAR T: antigen-driven CAR T (adCAR-T) expansion method enables rapid, physiological CAR T cells programming. biorxiv.org
Binary partitioning of human brain organization due to divergent human cytoskeletal evolution biorxiv.org
Repurposing native non-homologous end joining for multicopy random integration in Wickerhamomyces ciferrii biorxiv.org
Automated assembly of protein complexes from cryo-EM maps with structure-informed Monte Carlo Tree Search biorxiv.org
SpatialArtifacts: a computational framework for tissue artifact detection in spatial transcriptomics data biorxiv.org
Structure-Property-Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery biorxiv.org
Evolutionary Conservation and Divergence of CXCL17 orthologs: Functional Evidence in Reptiles and Loss in the Avian Lineage biorxiv.org
Efficient Optimization of Genotype Pairs for Intercropping using Genomic Prediction and Bayesian Optimization biorxiv.org
Environmental stochasticity can account for patterns of within-host respiratory virus evolution biorxiv.org
AlaRS-mediated lactylation shields PARP1 from ubiquitination to promote HNSCC progression biorxiv.org
Addiction-Like Severity Predicts Prolonged Oxycodone Withdrawal-Induced Allodynia in Genetically Diverse Rats biorxiv.org
Extending structural surfaceomics to identify aberrant conformations of tumor surface proteins as potential immunotherapy targets biorxiv.org
Mantis-Delta: Mass-Action Network Theory and Steady-State Characterization for Chemical Reaction Networks biorxiv.org
Combining amino acid frequency and 1D convolutional neural network embeddings for the identification of protein-protein interactions using a random forest classifier biorxiv.org
Time Restricted Feeding Mitigates High-Fat-Diet Induced Sleep Disruption and Amplifies NREM Substates biorxiv.org
SPATIAL HABITAT DIFFERENCES DRIVE ABUNDANCE OF RED-CHEEKED CORDON-BLEU IN HUMAN-MODIFIED LANDSCAPES biorxiv.org
The MICA rs2596542 locus is not an island: component-aware haplotype decomposition reveals a composite MHC tag with distinct regulatory axes biorxiv.org
kri-1/KRIT1 restrains skn-1/NRF2 activation to promote innate immune and lipid homeostasis biorxiv.org
Subsecond whole-brain neural dynamics identified by hidden Markov modeling reflect value-based decision making in humans biorxiv.org
Divergent scalp-to-region distance alteration patterns in autism spectrum disorders, Parkinson's disease and Alzheimer's disease biorxiv.org
Dopamine Depletion Drives Whole-Brain Oscillatory Disruptions via Cortico-Subcortical Resonance: A Multiscale Model of Parkinson's Disease in Mice biorxiv.org
Discovery of a Novel Non-MET-Mediated Otoprotective Compound Against Aminoglycoside-Induced Ototoxicity biorxiv.org