Restoration of E-cadherin Expression Alters Metastatic Organotropism in Invasive Lobular Breast Carcinoma Models biorxiv.org
Microbiota-gut-brain axis modulation drives glioblastoma progression and therapy resistance biorxiv.org
A Spatial Proteomic Atlas of Tertiary Lymphoid Structures in Non-Small Cell Lung Cancer Identifies a Novel Predictive Class of Lymphoid Aggregates biorxiv.org
Discriminative learning of substitution matrices and gap penalties for pairwise alignment of biological sequences biorxiv.org
SLE Monocyte Subsets Are Pro-Inflammatory and Display Dysregulated Metabolism in Response to Bacterial Stimuli biorxiv.org Systemic lupus erythematosus (SLE) is associated with infection susceptibility and altered innate immune function.
BLOC1S1 regulates autolysosomal and exosomal dynamics during CD4⁺ T cell differentiation biorxiv.org Although the endolysosome system is central to intracellular recycling, signal transduction, and intercellular communication via exocytosis, its role
β-Hydroxybutyrate elicits divergent metabolic responses between MCF-7 and T47D ER+ breast cancer cells under glucose restriction biorxiv.org Background: The ketogenic diet is being explored as an adjuvant intervention in breast cancer because it lowers circulating glucose and elevates keton
High-Throughput Characterization of Trends in Transmembrane Helix Partitioning into Membrane Domains biorxiv.org The plasma membrane is a laterally heterogeneous environment in which lipid organization plays a central role in regulating protein function.
Structure of the human HIRA histone chaperone with a nucleosome suggests a stepwise nucleosome assembly mechanism biorxiv.org The restoration of chromatin in the wake of a DNA or RNA polymerase is essential to maintain the integrity of eukaryotic genomes.
Characterization of spe-40/Fam187 identifies a deeply conserved sperm protein at the C. elegans fertilization synapse biorxiv.org
MYC overexpression drives poor prognosis and differential sensitivity to treatments according to TP53 status in chronic lymphocytic leukemia biorxiv.org
Metabarcode and transcriptome datasets of Pinus sylvestris to assess fungal phyllosphere and disease dynamics. biorxiv.org
Nutritional-Metabolic Lipid Profiling with LipidOne for plasma lipidomics interpretation in metabolic health biorxiv.org
The Paipu framework enables creation of a large-scale mammalian cancer transcriptomics atlas biorxiv.org
From Spectra to Digital Phenotypes: Wearable Multispectral Sensing for Precision Light and Green Space Exposure biorxiv.org
A Comprehensive Computational Model of the Human head for Designing and Optimizing Visual Brain-Machine Interfaces biorxiv.org
Large disruptions to mammalian spermatogenesis downstream of genetic perturbations in meiotic double-strand break repair biorxiv.org
SOX9 and SEMA7A regulate cell plasticity in the postpartum mammary gland with implications for breast cancer biorxiv.org
Type III Druantia two-component antiphage defense depends on the DruH-DruE interaction for halting phage DNA cyclization and replication biorxiv.org
Genomic Characterization of the RyC collection: 50 Multidrug Resistant Clinical Isolates of Escherichia coli and Klebsiella spp. biorxiv.org
Effective macrophage clearance of Klebsiella pneumoniae requires the inducible nitric oxide synthase iNOS and is independent of reactive oxygen species generated by NADPH oxidase biorxiv.org