Inbreeding depression by polygenic load following a severe population bottleneck biorxiv.org 2026-06-05 It is poorly understood how populations survive extreme bottlenecks despite severe inbreeding.
Long-read RNA-seq resolves isoform-level and context-specific regulatory architecture of complex traits in cattle biorxiv.org 2026-06-05 Traditional short-read RNA-seq lacks the resolution to fully capture full-length isoforms and complex alternative splicing, leaving a "missing regulat
Spatial engineering of posterior organizers in cerebral organoids via controlled morphogen exposure within hydrogels biorxiv.org 2026-06-05 Cerebral cortex organoids are powerful in vitro models that recapitulate key features of human development.
A mitochondrial-immune axis drives the transcriptomic transition from brain aging to Alzheimer's disease biorxiv.org 2026-06-05 Aging is the primary risk factor for Alzheimer's disease (AD), yet the molecular transitions linking normal brain aging to neurodegeneration remain po
Inherited input and local transformations shape the spatiotemporal organization of pathway specific striatal signals for motivated behavior biorxiv.org 2026-06-05 Adaptive behavior requires neural circuits to link sensory events with their location, predictive value, and temporal relationship to outcomes.
Predictive learning induces Bayesian cognitive maps in the hippocampus biorxiv.org 2026-06-05 Navigation requires perception: location must be inferred from noisy and ambiguous egocentric sensory inputs, as in visual estimation of distance.
Single-cell spatial transcriptomics and snRNA-seq decoding the organizational principles of functional modules in the mouse amygdala biorxiv.org 2026-06-05 The amygdala is a functionally heterogeneous nuclear complex comprising multiple subnuclei that orchestrate diverse behaviors, making it essential for
Asymmetric neural dynamics of visuospatial attention in autism spectrum disorder biorxiv.org 2026-06-05 Background: Selective attention enables the prioritization of behaviorally relevant information in complex sensory environments.
Very Early Cortical Auditory Responses to Speech in Humans biorxiv.org 2026-06-05 A foundational measure of the auditory system's ability to process sound correctly is the auditory brainstem response (ABR) and middle latency respons
Conjunctive coding of letter pairs emerges in segregated human medial temporal lobe neurons during working memory biorxiv.org 2026-06-05 Composing individual memory traces into unified representations is fundamental to encoding of structured relationships and flexible cognition.
Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability biorxiv.org 2026-06-05 Bipolar disorder (BD) is a severe psychiatric disease characterized by recurrent mania, depression, and circadian rhythm disruption.
Equivalent volitional learning emerges through circuit-specific population dynamics in motor cortex and hippocampus biorxiv.org 2026-06-05 Learning operates across different brain circuits to associate population activity patterns with desired outcomes, and to enable volitional reactivati
PEC: a robust algorithm to reconcile pedigree and SNP-chip data on the basis of LD block, haplotype information, and Mendelian conflicts biorxiv.org 2026-06-04 Motivation: Pedigree errors frequently occur in livestock populations due to long-term manual record-keeping, which reduces the efficiency of breeding
Cyclin C nuclear release and mitochondrial dysfunction define molecular signatures of MED13L Syndrome biorxiv.org 2026-06-04 The Mediator Kinase Module (MKM) coordinates transcriptional programs regulating cellular metabolism, stress responses, and differentiation.
A Non-Viral CRISPR/Cas9 HDR Platform for Stable Engineering of Solid Tumor Models. biorxiv.org 2026-06-04 Virus-free genome engineering provides a flexible alternative to viral vectors for generating genetically modified cell models.
De Novo Design and Computational Validation of a High-Affinity Peptide Inhibitor Targeting the HPV E1-E2 Interface biorxiv.org 2026-06-04 The oncogenic progression of high-risk Human Papillomavirus (HPV) strains relies fundamentally on the cooperative interaction between the E1 replicati
Nanobodies versus canonical antibodies: an updated comparison of their binding modes biorxiv.org 2026-06-04 Heavy-chain-only antibodies, produced by the adaptive immune systems of camelids and cartilaginous fish, complement canonical antibodies that contain
UnBlender: validating individual analyses in respiratory bulk RNA-seq cell type deconvolution biorxiv.org 2026-06-04 Analysis of RNA-seq data of respiratory samples has contributed much to our understanding of lung disease.
CD163 protects against pulmonary injury and inflammation induced by acute O3 exposure biorxiv.org 2026-06-04 Ozone (O3)-driven pulmonary inflammation is partly regulated by damage associated molecular patterns (DAMPs) binding to scavenging receptors (SRs).
Iron-Flavonoid-Peroxidase Signaling Triggers Seed-Coat Remodeling for Rapid Germination biorxiv.org 2026-06-04 Seed germination and survival depend on a sustained water supply. The mechanisms by which seeds determine how much water is available remain elusive.
Lumbar intrathecal catheterization in rats targeting the cerebral cortex: a drug delivery method and validation biorxiv.org 2026-06-04 Intrathecal (IT) drug delivery is a critical technique for bypassing the blood-brain and blood-spinal cord barriers in preclinical CNS research.
Electrophysiological Signature of Stroke Recovery: Investigating EEG Biomarkers for Prognostic Insights biorxiv.org 2026-06-04 Stroke is a leading cause of long-term disability, often resulting in persistent motor impairments reflecting disruptions in large-scale brain network
Hemodynamic Responses in the White Matter (WM): Reduced Blood Flow in Deep WM During Hypercapnia Revealed by Multi-Delay pCASL in Healthy Young Adults biorxiv.org 2026-06-04 The white matter (WM) cerebrovascular response remains poorly understood compared with grey matter (GM), partly due to technical challenges in perfusi
Inhibition of Soluble Epoxide Hydrolase Rescues Cognitive Deficits by Preserving Neurovascular Integrity and Attenuating Glial- and Neuropathology in Diabetic-Related Dementia biorxiv.org 2026-06-04 Diabetes mellitus (DM) is a major risk factor contributing to the development of Alzheimers disease-related dementias (ADRD).
From anti-fungal to potential neurotherapeutic: Posaconazole as an effective inhibitor of cellular TDP-43 pathology biorxiv.org 2026-06-04 Recently, we showed that ketoconazole, a known anti-fungal inhibitor of CYP51, stabilized TAR DNA-binding protein 43 (TDP-43) native self-interactions
Legacy Effects of Land-Use Land-Cover Change on Species Distribution Dynamics: Evidence from a landscape of diverse biogeographic crossroads biorxiv.org 2026-06-04 Land-use and land-cover (LULC) change is a dominant driver of biodiversity loss, yet its long-term role in restructuring species distribution remains
Progressive matrix stiffening of tyramine-modified silk fibroin hydrogels governs stage-specific pulmonary fibroblast activation biorxiv.org 2026-06-04 Fibrosis is a progressive and often fatal pathological process characterized by excessive extracellular matrix deposition, tissue stiffening, and irre
Predicting P-glycoprotein Substrate Status Using a Pretrained Graph Neural Network: A TDC Benchmark Study biorxiv.org 2026-06-04 P-glycoprotein (Pgp/ABCB1) is a critical efflux transporter that significantly impacts drug bioavailability and multidrug resistance.
Local sequence context determines the effect of glycine substitutions in collagen triple helices biorxiv.org 2026-06-04 Glycine substitutions in the collagen triple helix cause diverse heritable disorders, but their effects vary with local sequence environment.
Sequence charge decoration organizes salt response regimes in intrinsically disordered proteins: an interpretable machine-learning biorxiv.org 2026-06-04 The conformational ensembles of intrinsically disordered proteins (IDPs) respond sensitively to ionic strength, with the direction and magnitude of re