Selective inhibition of respiratory complex I reveals a bioenergetic vulnerability in Francisella biorxiv.org 2026-06-05 F. tularensis is a highly infectious Gram-negative bacterial pathogen that causes tularemia, a re-emerging zoonosis of public health concern.
Flagellar system translocates T3SS effectors critical for Salmonella infection biorxiv.org 2026-06-05 Type 3 secretion system (T3SS) injectisomes, the essential virulence factors of many bacterial pathogens, are thought to have evolved from the flagell
Microbial community profiles of the snake cloaca in the presence and absence of Chlamydiota biorxiv.org 2026-06-05 Chlamydiota are obligate intracellular bacteria detected in snake cloacal microbiota, yet their biological significance remains poorly understood.
Transcription factor CCTF1 plays a decisive role in regulating the proteasome activity during archaeal cell division biorxiv.org 2026-06-05 Archaea of the order Sulfolobales exhibit a highly ordered cell cycle progression similar to that of eukaryotes.
Structural and Catalytic Architecture of the Cysteine Synthase Cys1a biorxiv.org 2026-06-05 Antifungal drug resistance in Aspergillus fumigatus is a major global health concern.
Intraspecific genetic variation modulates immune responses to acute heat exposure in an aquatic ectotherm biorxiv.org 2026-06-05 Climate change-induced heatwaves threaten ectotherms, whose physiology is tightly coupled to ambient temperature.
Night-time control of carbohydrate availability in grasses differs radically from that in Arabidopsis biorxiv.org 2026-06-05 Grass leaves reportedly accumulate sucrose during the day then export it to other organs at night. The control of export at night is not understood.
Modeling the journey as well as the destination: a control theory account of rotational navigation biorxiv.org 2026-06-05 Navigation requires estimating heading and transforming these estimates into actions.
Rapid Determination of Drug-to-Antibody Ratios in Antibody Drug Conjugates Using Ultrafast Microdroplet Digestion Technology biorxiv.org 2026-06-05 Accurate determination of drug to antibody ratios (DARs) is essential for the development, quality control, and performance evaluation of antibody dru
Split intein vectors permit oversize FLIM-FRET biosensor neuronal expression biorxiv.org 2026-06-05 Adeno-associated virus (AAV) packaging limits constrain the design, performance, and in vivo application of genetically encoded biosensors.
Maturation of Gait: Identification of Locomotor Profiles from Early Childhood to Adulthood biorxiv.org 2026-06-05 Background: Human gait is a key marker of motor development.
Label-Free AI-Classification of Subcellular Organelles Based on Optical Photothermal Infrared Images biorxiv.org 2026-06-05 Cells maintain homeostasis by dynamically reorganizing their organelles to tune metabolism in response to stress.
Extrachromosomal DNA as a Causal Instrument for Spatial Multi-Omics biorxiv.org 2026-06-05 Spatial transcriptomics, multiplex imaging, and computational pathology now map tissue organization at cellular resolution, but the analyses applied t
Lifespan Trajectories of Resting State EEG power biorxiv.org 2026-06-05 Trajectories of resting state monopolar EEG power were analyzed using the means, variances, and correlations of data in seven frequency bands obtained
Aβ Aggregates Bind the U1 Spliceosomal Ribonucleoprotein in Alzheimer Disease Brain biorxiv.org 2026-06-05 Missplicing due to U1 small nuclear ribonucleoprotein (U1 snRNP) insolubilization and dysfunction has been identified in Alzheimer disease (AD) brain.
A unified developmental framework of the human placenta in its uterine environment in vivo and in vitro biorxiv.org 2026-06-05 Despite advances in single-cell profiling of the human placenta, the genetic programs governing its physiological remodeling throughout gestation rema
Genomic Dimensionality Bounds Mixed-Model Association Power and Fine-Mapping Resolution biorxiv.org 2026-06-05 Mixed-model genome-wide association studies (GWAS) behave differently in livestock than in humans, yet a unified explanation is lacking.
Loss of the Y chromosome drives epigenetic and transcriptomic plasticity in lung adenocarcinoma biorxiv.org 2026-06-05 Loss of the Y chromosome (LOY) is associated with poor survival across multiple solid tumors, yet the underlying molecular mechanisms remain poorly un
Afrothismia lovettii sp. nov. (Afrothismiaceae) Critically Endangered (Possibly Extinct) and endemic to the Kihansi Falls Forest, Tanzania biorxiv.org 2026-06-05 The fully mycotrophic (or mycoheterotrophic) non-photosynthetic Afrothismia lovettii Cheek sp. nov.
Orientation Dependence of R2' in White Matter: Digital Characterization, Modelling and Implications for Studying Brain Physiology biorxiv.org 2026-06-05 Introduction R2* is the transverse relaxation rate of tissue, influenced by local magnetic field inhomogeneities arising from susceptibility differenc
HDAC3 inhibition stabilizes the IL-37 receptor module to enhance anti-inflammatory signaling in cystic fibrosis airway epithelium biorxiv.org 2026-06-05 Airway inflammation in cystic fibrosis (CF) persists despite advances in CFTR modulator therapy.
Phylogeny, thermal seasonality, and life history shape trait variation in annual and perennial barley relatives biorxiv.org 2026-06-05 Summary {middle dot} There is growing interest in developing perennial cereal crops for sustainable production, yet key differences in trait syndromes
Identification of novel enolase negative Segatella copri subspecies supports notion of Segatella copri speciation via alternative phosphoenolpyruvate synthesis pathways biorxiv.org 2026-06-05 Segatella copri is characterised as a prominent glycolytic plant-based fiber utiliser within the human gut.
Rational engineering of sdAb-based CAR T cells targeting BCMA enhances antitumor efficacy and persistence in Multiple Myeloma biorxiv.org 2026-06-05 BCMA-directed CAR T therapies have transformed the treatment of relapsed/refractory multiple myeloma (MM), yet durable responses remain limited by ins
Cellpin enables reference-based imputation and denoising of spatial transcriptomes biorxiv.org 2026-06-05 Spatially resolved transcriptomics enables gene expression profiling within tissue architecture, but targeted panels leave much of the transcriptome u
Locus coeruleus activation transforms cortical taste representations biorxiv.org 2026-06-05 Norepinephrine neurons in the locus coeruleus (LC) shape sensory responses across the brain, yet how LC activity reorganizes population representation
Distinguishing Photoacoustic and Photothermal Neuron Stimulation Through Quantitative Mapping Spatiotemporal Field Evolution biorxiv.org 2026-06-05 Neuromodulation is a rapidly advancing strategy for modulating brain function and treating neurological disorders, yet the mechanisms of optical neura
Stimulus-Specific and Generalized Taste Aversion Behaviors and Their Relationship to Cortical Dynamics biorxiv.org 2026-06-05 Aversive taste behaviors, such as gaping, are commonly viewed as fixed, hard-wired responses important for ejecting potentially toxic tastes from the
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA biorxiv.org 2026-06-05 Enteroendocrine cells (EECs) are specialized sensors of the gastrointestinal (GI) epithelium that regulate gut function and systemic metabolism throug
Auditable recovery of single-cell RNA-seq zeros with SPARE biorxiv.org 2026-06-05 In Single-cell RNA-seq, observed zeroes are the mix between biological absence and technical limitations.