Endosomal mRNA transport coordinates local mitochondrial bioenergetics during polar fungal growth biorxiv.org 2026-06-12 Mitochondrial function relies on the precise spatial coordination of protein synthesis and import.
A metabolic checkpoint coordinates bacterial cell envelope biosynthesis and c-di-GMP signaling biorxiv.org 2026-06-12 The bacterial second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) drives the transition from motile to biofilm lifestyles, yet the mech
Molecular and ecological determinants of effective reassortment in orthohantaviruses biorxiv.org 2026-06-12 A central unsolved problem in RNA virus evolution is understanding why some viral reassortants establish and persist while others do not.
Unraveling candidate genomic regions responsible for delayed post-harvest deterioration in Cassava (Manihot esculenta Crantz) biorxiv.org 2026-06-12 Post-harvest physiological deterioration (PPD) represents a significant challenge of cassava production and commercialization.
Unlocking viral evasion: Luminal charge interactions in BoHV-1 UL49.5 allosterically control TAP degradation biorxiv.org 2026-06-12 The UL49.5 protein of bovine alphaherpesvirus 1 (BoHV-1) is known to inhibit the transporter associated with antigen processing (TAP) and interfere wi
Emulating the gingival-tooth interface during bacterial, fungal, and viral infection in a microphysiological model of the human oral cavity biorxiv.org 2026-06-12 The anatomical complexity and distinctive tissue environment of the human oral cavity pose major challenges to modeling oral infection and host-microb
Computational Design of Optimal Sequences for Targeted Hypermutagenesis Using Recombination-Coupled Diversity-Generating Retroelements biorxiv.org 2026-06-12 Diversity-generating retroelements (DGRs) are natural systems that accelerate evolution via targeted hypermutation at adenines.
ProMiSE: Protein Multi-State Evaluation Benchmark in Biological Contexts biorxiv.org 2026-06-12 Proteins are inherently dynamic, with biological functions often emerging from transitions between multiple conformational states.
The role of the neutrophil receptor Mrgpra2 in the formation of itch in atopic dermatitis biorxiv.org 2026-06-12 Atopic dermatitis (AD), or eczema, is estimated to affect more than 30 million people in the United States, with over 6 million have moderate or sever
XL-MS-Guided Structure Prediction of Disordered Encephalitozoon hellem Proteins biorxiv.org 2026-06-12 Microsporidia such as Encephalitozoon hellem are obligate intracellular human parasites that remain genetically intractable, limiting functional chara
Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression biorxiv.org 2026-06-12 Perturbation to the early-life microbiota has long-term detrimental effects on health and development, leading to increased risk for metabolic dysfunc
Postpartum Systemic Inflammation is Reflected in Early Distinct Fecal Microbiome Differences in Dairy Cows biorxiv.org 2026-06-12 A tightly regulated inflammatory response occurs during and following parturition; however, excessive or prolonged inflammation negatively affects her
Pathogenesis and host response to a novel Tacaribe virus isolate in experimentally-infected Jamaican fruit bats biorxiv.org 2026-06-12 Tacaribe virus (TCRV) was the first arenavirus discovered in the New World and was isolated from Artibeus bats in Trinidad and Tobago in the 1950s.
Antimicrobial and Cytotoxic Lysolipins I-M Isolated from Streptomyces sp. P8-2B18 biorxiv.org 2026-06-12 Lysolipin I (1) is a highly bioactive xanthone with strong antibacterial and cytotoxic properties.
Primary and secondary antiviral RNAi responses throughout Varroa destructor life stages reveal the vertical transmission of viruses biorxiv.org 2026-06-12 One of the most devastating threats to global honey bee health is the ectoparasitic mite and viral vector Varroa destructor, yet the transmission dyna
CORe Designer: a CRISPR design tool for proteome engineering biorxiv.org 2026-06-12 Precision proteome engineering requires tools that leverage CRISPR technologies, yet most current design platforms remain gene-centric.
BacPROTACs outperform inhibitors in Mycobacterium tuberculosis biorxiv.org 2026-06-12 Antibiotic discovery has long relied on occupancy-driven inhibition, leaving a vast number of potential bacterial targets undrugged.
The efficiency of different transmission routes of Xanthomonas citri pv. fuscans and other seed-borne bacteria to bean seeds. biorxiv.org 2026-06-12 Seed transmission is a critical pathway for the dispersal of phytopathogenic bacteria.
Rust fungi secretomes contain structurally diverse effector families including cysteine-rich metal-binding proteins biorxiv.org 2026-06-12 Rust fungi are significant threats to global food security, causing substantial damage to crops through their ability to adapt and evolve new strains
Reward network state dynamics track ASD symptom severity but not diagnosis biorxiv.org 2026-06-12 Autism spectrum disorder (ASD) is a heterogeneous developmental condition characterized by repetitive behaviors and social communication difficulties.
Time, but not reward, shapes replay-based episodic prioritization biorxiv.org 2026-06-12 Why are some experiences remembered better than others?
The dynamic relationship between pupil dilation and neural surprise in natural language comprehension biorxiv.org 2026-06-12 Predictive processing accounts hold that the brain continuously generates predictions and updates internal models from error signals, but it remains u
Developmental emergence of spatiotemporal coordination in cerebellar Purkinje cell populations biorxiv.org 2026-06-12 Coordinated neuronal population activity is essential for brain function, yet how such network-level organization emerges during development remains i
Interplay of sleep neural oscillations enhances coordinated memory reactivation between cortex and hippocampus biorxiv.org 2026-06-12 Memory consolidation during sleep requires coordinated reactivation of specific experiences across hippocampus and cortex.
Movement planning predictions shape somatosensory sensitivity biorxiv.org 2026-06-12 Tactile sensitivity is reduced during limb movement, a phenomenon known as somatosensory gating.
Dorsomedial Striatum Calcium Permeable AMPA Receptors in the Development of Aversion-Resistant Alcohol Drinking biorxiv.org 2026-06-12 Rationale: Alcohol use disorder is defined by drinking alcohol despite knowledge of negative consequences, often referred to as aversion-resistant dri
Intact learning and memory in mice incapable of de novo myelination biorxiv.org 2026-06-12 Motor skill learning stimulates and requires generation of oligodendrocytes (OLs) from their precursors (OLPs) in the adult mouse brain, but the funct
Developmental coordination disorder affects the pre-ordering of sequential movements biorxiv.org 2026-06-12 Research suggests that motor difficulties in Developmental Coordination Disorder (DCD) are related to altered motor sequence planning, but it is uncle
Macroevolutionary shifts in post-hatching ontogeny and the origin of craniofacial disparity in fowl (Aves: Galloanserae) biorxiv.org 2026-06-12 Anseriformes (waterfowl) and Galliformes (landfowl) are among the world most recognisable groups of birds, together comprising the clade Galloanserae.
Enhancer pioneering activity of Wnt/β-catenin signaling biorxiv.org 2026-06-12 Wnt/{beta}-catenin signaling is widely understood as a molecular switch that activates preprogrammed regula-tory states.