A ribosomal kinetic checkpoint governs selective mRNA recruitment biorxiv.org 2026-06-13 Translation initiation begins with recruitment of mRNA to the ribosome, yet how mRNA engagement is converted into productive initiation remains unclea
Unlocking Your Programmable and Creative RNA Sequence Designer with RDiffusion biorxiv.org 2026-06-13 As a cornerstone of the central dogma, RNA has both witnessed and actively shaped three billion years of evolution.
Continuous Capture of recombinant AAV Particles Using Twin-Column CaptureSMB biorxiv.org 2026-06-13 Recombinant adeno-associated viruses (rAAVs) have gained increasing importance in gene therapy due to their safe and precise gene delivery.
Virus-human protein-protein interactions predict viral phenotypes biorxiv.org 2026-06-13 Viral phenotypes such as host and tissue tropism are critical determinants of viral infection and transmission.
Testing the reliability of AI-generated protein structures biorxiv.org 2026-06-13 Although AlphaFold2 and its competitors have demonstrated remarkable abilities to predict protein structure, more work is needed to explore the limita
ADMETron: An AI-driven SaaS platform for comprehensive ADMET prediction and compound prioritisation biorxiv.org 2026-06-13 ONTOSIGHT(R) ADMETron is an AI-driven platform designed for rapid prediction and visualization of Absorption, Distribution, Metabolism, Excretion, and
MoE-Bind: Guiding De Novo Protein Binder Generation with Sparse Experts biorxiv.org 2026-06-13 De novo protein binder design has been dominated by structure-based pipelines that require known three-dimensional target conformations and consume su
Tightly Knotted Enzymes Inhibit Protein-Protein Aggregation biorxiv.org 2026-06-13 Neurodegenerative diseases are closely linked to aberrant protein aggregation arising from failures in cellular proteostasis, yet the physical determi
Microbial inoculation accelerates post-fire soil recovery in a mixed conifer forest biorxiv.org 2026-06-13 High-severity wildfires of increasing size and frequency result in release of carbon dioxide and loss of timber resources, reduction in biodiversity,
Molecular interplay between Integrative Mobile Elements exploiting Xer drives the evolution of cholera pandemics biorxiv.org 2026-06-13 XerC and XerD are ubiquitous bacterial recombinases dedicated to chromosome dimer resolution.
A genome wide antigen-antibody screen identifies a yeast-based therapeutic vaccine candidate for Chagas disease biorxiv.org 2026-06-13 Chagas disease is caused by Trypanosoma cruzi infection and results in decades-long, chronic, debilitating, and lethal disease.
First detection and characterization of Alongshan virus in Ixodes ricinus ticks from Italy, 2021-2022 biorxiv.org 2026-06-13 Alongshan virus (ALSV) is an emerging tick-borne segmented RNA virus belonging to the Jingmenvirus group and has been reported in humans, ticks, and v
Saturation Genome Editing reveals the functional impact of RAD51D and XRCC2 variants biorxiv.org 2026-06-13 Germline pathogenic variants in RAD51D and XRCC2, which encode RAD51 paralogs that form a heterodimer within the BCDX2 complex, confer increased cance
DNA 6mA marks transcriptionally active chromatin in malaria parasites biorxiv.org 2026-06-13 DNA N6-methyladenine (6mA) has emerged as a significant epigenetic modification across a broad range of eukaryotes, from unicellular protists to metaz
Potential for the Terminal SKP1 Glycosyltransferase to Exert Non-Enzymatic Control of SKP1 in Toxoplasma gondii biorxiv.org 2026-06-13 The SKP1/Cul1/F-Box (SCF) complex is an E3 ubiquitin ligase responsible for targeting a range of proteins for degradation by the 26S proteosome.
Intrinsically disordered N-terminal regions suppress cotranslational protein degradation biorxiv.org 2026-06-13 Intrinsically disordered regions (IDRs) of proteins are thought to be inherently sensitive to proteolysis and considered one of the key components con
ProtAff: Protein Binding Affinity Prediction via LoRA-Finetuned ESM-2 biorxiv.org 2026-06-13 Predicting the binding affinity of protein--protein interactions remains a central challenge in computational biology.
Reinforcement learning-driven unified generative framework for multi-objective RNA codon design biorxiv.org 2026-06-13 Current RNA codon design methods are limited by inefficient long-sequence processing and poor generalizability, often relying on a decoupled "generate
PertDiffBench: Benchmarking Diffusion Models for Single-Cell Perturbation Response Prediction biorxiv.org 2026-06-13 Diffusion models are increasingly used to predict transcriptional responses to perturbations, but whether they improve on simpler generative and repre
Coupled nucleoplasmic flows and envelope expansion govern the mechanical resistance of the nucleus biorxiv.org 2026-06-13 In recent year, it became clear that the cell nucleus can undergo large deformations, during immune cell migration and tumor growth.
Disruption of Myelin-Associated Glycoprotein Activity Drives Aberrant Cerebellar Neurodevelopment and Autism-Like Behaviors. biorxiv.org 2026-06-13 Immune-mediated mechanisms have emerged as important contributors to neurodevelopmental vulnerability in a subset of autism spectrum disorder (ASD) ca
Cortical geometry constrains the unimodal anchors of sensory integration biorxiv.org 2026-06-13 The human cerebral cortex is organized along a unimodal-to-transmodal hierarchy, which provides a putative substrate for the integration of sensory si
The Amygdalostriatal Transition Area Exhibits Lateral Amygdala-Like Spiking Activity and Tone-Shock Pairing-Induced Plasticity biorxiv.org 2026-06-13 During Pavlovian fear conditioning, presentation of a conditioned stimulus, such as a tone, together with an unconditioned stimulus, such as an electr
Post-translational modifications in the brain are critical contributors to Alzheimers disease neuropathology and cognitive decline biorxiv.org 2026-06-13 Post-translational modifications (PTMs) in APP and MAPT contribute to plaques and tangles in Alzheimers disease (AD).
The Logic of Thalamic Inputs onto the Molecular Taxonomy of Cortical Neurons Reveals a Visual Hierarchy biorxiv.org 2026-06-13 The hierarchical organization of sensory cortices and the rich molecular taxonomy of their cell types are defining features of the mammalian cortex.
Extracranial lymphatic-venous anastomosis remodels the choroid plexus-vascular axis in Alzheimer's disease biorxiv.org 2026-06-13 Coordination of brain fluid transport, proteostasis, and vascular function is essential for neural homeostasis, yet whether extracranial lymphatic out
Lesion-Gradient Mapping in Semantic Aphasia: Comparisons of Observed and Simulated Effects of Stroke on Connectivity Gradients biorxiv.org 2026-06-13 Post-stroke semantic aphasia is characterised by multimodal semantic deficits and reflects disruption of a distributed brain network spanning frontal
Dual Developmental Origins and Activity-dependent Specification of Mammalian Subplate Neurons biorxiv.org 2026-06-13 Subplate neurons (SpNs) are among the earliest-generated cortical neurons and are essential for neocortical circuit assembly.
Wavelet analysis of human recombination rates demonstrates divergence on fine scales biorxiv.org 2026-06-13 Background: Recombination rates can be estimated across the genome, underpinning genetic analyses such as identification of regions under selection.
Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in Cryptococcus neoformans biorxiv.org 2026-06-13 Cryptococcus neoformans is the leading cause of fungal meningitis in immunocompromised patients.