MetaPilot: genome-aware adaptive search-space refinement for unified DDA and DIA metaproteomics biorxiv.org 2026-06-16 Metaproteomic peptide identification is constrained by the structure and size of the protein search space.
OmicOS: A Comprehensive Omics Ecosystem Infrastructure and Agent System for the AI Era biorxiv.org 2026-06-16 Biology has accumulated a vast ecosystem of omics methods, but much of this ecosystem remains built for expert humans rather than scientific agents.
THEOBROMA: an aggregated open database of 1.13 million natural products with per-compound license auditing, three-tier classification, and stereochemistry-aware deduplication biorxiv.org 2026-06-16 Natural products remain one of the most productive sources of pharmacologically active compounds for drug discovery, yet the current open aggregator l
Buprenorphine Restricts the Conformational Landscape of the μ-Opioid Receptor biorxiv.org 2026-06-16 Biased signaling and partial agonism in GPCRs are considered promising strategies to develop safer and more effective drugs.
Dissecting and directing pathology foundation models biorxiv.org 2026-06-16 Foundation models (FMs) are central to digital pathology, encoding histology images into dense embeddings for facilitating diagnostic classification,
The fungicide mancozeb induces astrocyte atrophy and disrupts Calcium signaling via inhibition of Orai1/STIM1-mediated SOCE biorxiv.org 2026-06-16 Mancozeb, a widely used fungicide composed of manganese ethylene-bis-dithiocarbamate with zinc salts, has raised concerns due to its potential neuroto
Induced alanine auxotrophy as a therapeutic strategy against Mycobacterium tuberculosis biorxiv.org 2026-06-16 New antitubercular agents that act through previously unexploited mechanisms are urgently needed.
AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid Pathology biorxiv.org 2026-06-16 The inhibitory microglial receptor LILRB4 (ILT3) suppresses amyloid-beta clearance in Alzheimers disease (AD) through ApoE-dependent signaling but rem
The Two Tube Volatile Assay: a non-contact benchtop bioassay for monitoring susceptibility to transfluthrin biorxiv.org 2026-06-16 Introduction: Progress against malaria has stalled since 2015, with insecticide resistance a key driver.
Chronic alpha-Synuclein Over-Expression and Ceruloplasmin Challenge Promote Distinct Iron and Redox Responses in M17 Cells biorxiv.org 2026-06-16 Abstract Background: While alpha-synuclein (alpha-syn) accumulation and iron dysregulation are hallmarks of Parkinson's Disease, the adaptations that
Context-dependent effects of microglial MyD88 removal on voluntary ethanol consumption in mice biorxiv.org 2026-06-16 Neuroimmune signaling is increasingly implicated in alcohol use disorder (AUD).
Ratiometric iGluSnFr imaging to assess tonic glutamate in the cerebral cortex biorxiv.org 2026-06-16 Tonic glutamate signaling by ambient levels of extracellular glutamate has been implicated in development, brain injury, pathologies, and physiologica
DeltaQ: Value-Guided Hebbian Learning in Spiking Neuronal Networks for Multi-Goal Navigation biorxiv.org 2026-06-16 Animals must often navigate environments where feedback about progress toward a goal is sparse or delayed, requiring internal representations of space
Stimulus identity rather than emotion drives EEG classification on the FACED dataset biorxiv.org 2026-06-16 Reliable benchmark datasets are critical for advancing EEG-based emotion recognition.
Distinct brain responses to psilocybin and escitalopram in depression captured by the Fluctuation-Dissipation Theorem biorxiv.org 2026-06-16 In recent decades, the psychedelic psilocybin has been studied as a potential treatment for major depressive disorder (MDD), offering an alternative t
The ENIGMA-PD-WML Pipeline: A Containerized, User-Friendly Approach for Accurate, Standardized Segmentation of White Matter Lesions in Multi-Site MRI Data biorxiv.org 2026-06-16 Understanding vascular contributions to disease is a major unmet need.
Modeling quantifies in vivo neutralization, Fc-mediated killing, and resistance in human clinical trials of five anti-HIV broadly neutralizing antibodies biorxiv.org 2026-06-16 Broadly neutralizing antibodies (bnAbs) are a promising intervention for HIV prevention, therapy, and cure.
Identifying Ecological Restoration Priority Areas through a Function-Structure-Dynamic Framework: Integrating Ecological Security Patterns and Future Land-Use Simulation in the Anhui Section of the Yangtze River Basin biorxiv.org 2026-06-16 Rapid urbanization has intensified ecological degradation and threatened ecosystem sustainability in the Yangtze River Basin.
Blockages to biodiversity data access for conservation and sustainability management biorxiv.org 2026-06-16 Governments, civil society organizations and businesses often lack the biodiversity data they need for decision-making and adaptive management, impact
Are bio-sourced nanoplastics inert for aquatic species? A toxicity study on three micro-algae species and a freshwater bivalve biorxiv.org 2026-06-16 Concerns raised by ubiquitate plastic contamination are urging to develop alternative materials.
Physics-Driven Zero-Shot Reconstruction of Isotropic 3D Fluorescence Microscopy under Undersampled Acquisition biorxiv.org 2026-06-16 Three-dimensional (3D) imaging represents the development of next generation of fluorescence microscopy.
DynamicDemiLog: A Single Sketch for Ultrafast Similarity, Frequency, and Cardinality Estimation biorxiv.org 2026-06-16 Probabilistic cardinality estimators (HyperLogLog), similarity sketches (MinHash), and frequency estimators (Count-Min Sketch) are fundamental approxi
α-synuclein pathology drives multi-scale reorganization of fronto-limbic networks and cognitive flexibility in the common marmoset biorxiv.org 2026-06-16 Understanding how -synuclein misfolding and spreading affect brain systems is central to synucleinopathy research, yet evidence from primate models re
Microplastics disrupt adaptive predator-induced behavioural plasticity in Rana dalmatina tadpoles biorxiv.org 2026-06-16 The accumulation of microplastics (MP; plastic particles 1 {micro}m - 1 mm in diameter) in the environment is an increasing global concern.
Translating Innovation to Clinic: End-to-End Bioprocess Development and cGMP Manufacturing of N332-GT5 HIV Vaccine Candidate for First-in-Human Trials HVTN144 biorxiv.org 2026-06-16 The successful translation of rationally designed HIV-1 immunogens into effective vaccines requires manufacturing platforms that maintain structural c
High-resolution image-projection fluorescence lifetime imaging microscopy biorxiv.org 2026-06-16 Fluorescence lifetime imaging microscopy (FLIM) provides molecular contrast that is largely independent of fluorophore concentration, yet it remains c
Coherent Structured Illumination Microscopy with Enhanced Optical Sectioning biorxiv.org 2026-06-16 Coherent structured illumination microscopy (c-SIM) is a synthetic aperture optical technique for sub-diffraction limit imaging that extends the utili
Novel bile salt analogs reduce lipid accumulation in liver cells with potential to treat both metabolic dysfunction-associated steatotic liver disease and Clostridioides difficile infection biorxiv.org 2026-06-16 Abstract: Metabolic dysfunction-associated steatotic liver disease (MASLD) and Clostridioides difficile (C.
Cold, dark, and hungry: Dynamic transcriptional regulation across eight months of brumation biorxiv.org 2026-06-16 Long-term winter dormancy in ectotherms (brumation) defines the annual cycle of many temperate-zone reptiles, yet the transcriptional regulation that
Global threat abatement potential for terrestrial vertebrates biorxiv.org 2026-06-16 Aim: The Species Threat Abatement and Restoration (STAR) metric was developed to support setting and measuring progress towards science-based targets