ESCRT Machinery Dysfunction in Motor Neurone Disease: TSG101, CHMP2B, and VPS4a Differentially Regulate TDP-43 Pathology, Autophagy, and Exosome Biogenesis biorxiv.org 2026-07-04 Motor Neurone Disease (MND) is characterised by progressive degeneration of upper and lower motor neurons, accompanied by cytoplasmic mislocalisation
Quantitation of Spatial Proteoforms in Alzheimer's Disease biorxiv.org 2026-07-04 Alzheimer's disease (AD) pathogenesis involves complex, multifactorial changes to the brain proteome that conventional unfractionated analyses may obs
Single-cell analysis of an adult IBD INCEPTION cohort reveals Galectin-linked disease mechanisms biorxiv.org 2026-07-03 Background and Aims: The molecular pathogenesis of Inflammatory Bowel Disease (IBD) remains unclear.
Variable latency between the founder genetic event and rhabdoid tumor expansion biorxiv.org 2026-07-03 Rhabdoid tumors are very aggressive rare pediatric cancers with poor survival affecting very young children.
From junk to deleterious: Natural subtelomeric repeat amplifications impact fitness and cellular phenotypes in yeast biorxiv.org 2026-07-03 Eukaryotic genomes exhibit astounding levels of complexity.
Long-range regulatory target prediction reveals shared genetic background across ulcerative colitis, Crohn's disease, primary sclerosing cholangitis and ankylosing spondylitis biorxiv.org 2026-07-03 Common variants detected by the genome-wide association studies (GWAS) create a wealth of knowledge on genetic component of individual traits and dise
Spatial and functional mapping of the human pancreas reveals endocrine and exocrine cell states in health and metabolic disease biorxiv.org 2026-07-03 The human pancreas contains diverse endocrine and exocrine cell populations whose spatial organization is essential for tissue physiology.
Generative cell phenotyping with structured latent populations biorxiv.org 2026-07-03 Flow cytometry produces high-dimensional single-cell protein measurements central to immunophenotyping and clinical monitoring.
Phosphorylation-dependent Remodeling of the CLOCK/BMAL1/nucleosome Complex biorxiv.org 2026-07-03 Phosphorylation of the CLOCK/BMAL1 complex is a reversible post-translational modification that plays a central role in regulating circadian oscillati
Direct visualization of Na,K-ATPase clustering by 3D DNA-PAINT MINFLUX nanoscopy biorxiv.org 2026-07-03 Direct validation of the nanoscale structural organization of membrane proteins requires localization precision that matches their molecular dimension
β-alanine betaine and nAChRs in Ascaris biorxiv.org 2026-07-03 Anthelmintic drugs are used to control soil-transmitted helminths that infect a third of the worlds human population.
Circulating soluble urokinase-type plasminogen activator receptor reflects disease severity in a mouse model of diabetic kidney disease and heart failure with preserved ejection fraction biorxiv.org 2026-07-03 Circulating biomarkers are increasingly used for patient risk stratification in chronic kidney disease (CKD) and heart failure with preserved ejection
GDF5 as a Multimodal Protector of the Motor Unit in Amyotrophic Lateral Sclerosis biorxiv.org 2026-07-03 Amyotrophic lateral sclerosis is characterized by the progressive dismantling of the motor unit.
Human primary auditory cortex and insula encode perceptual decisions, not stimulus features biorxiv.org 2026-07-03 The traditional view of perceptual decision-making assumes a largely feedforward cortical hierarchy, in which sensory regions encode stimulus features
Shared and disease-specific human brain vascular signatures in Alzheimer's disease, frontotemporal dementia, and Huntington's disease biorxiv.org 2026-07-03 The blood-brain barrier (BBB) plays a central role in brain function and is increasingly implicated in neurodegenerative disease.
PACAPergic BAC engages basolateral amygdalar and anterodorsal thalamic networks during looming-threat learning and memory in a labyrinth biorxiv.org 2026-07-03 The bed nucleus of the anterior commissure (BAC) is a small pituitary adenylate cyclase-activating polypeptide (PACAP)-rich glutamatergic cell populat
Dense CRISPR Mapping of the WAVE Complex Identifies Pharmacological Modulators of AD-Linked Myeloid Migration biorxiv.org 2026-07-03 Although genetic risk for Alzheimer's disease (AD) strongly converges on microglial pathways, the druggable functional protein regions that control di
Trans-presentation of IL-15 by IL15Rα attenuates tumor immune surveillance and is dispensable for IL-15-dependent tumor growth control biorxiv.org 2026-07-03 Abstract Introduction: IL-15 is one of the most promising candidate cytokines in cancer immunotherapy due to its ability to promote the activity of di
Long-read sequencing maps transposable element variation and its regulatory and epigenetic effects in the human brain biorxiv.org 2026-07-03 Transposable elements (TEs) are mobile DNA sequences that shape genome architecture and gene regulation, yet their roles in the human brain remain lar
Social isolation biases female rats toward safety-oriented, efficient foraging biorxiv.org 2026-07-03 Social isolation has profound effects on behavior and cognition, but these effects can differ across sex and behavioral domains.
AptBacterialDB: A Comprehensive, Manually Curated Database of Antibacterial Aptamers biorxiv.org 2026-07-03 In recent years, aptamers have transitioned from mere laboratory tools to highly potent molecular recognition agents capable of overcoming the strict
Older adults show overexaggerated and larger noise-related degradation in their neural tracking of speech biorxiv.org 2026-07-03 Background: Speech-in-noise (SIN) perception is a difficult everyday listening task that becomes more difficult with age.
Intratelencephalic neurons in the medial prefrontal cortex mediate the acquisition of goal-directed actions. biorxiv.org 2026-07-03 The medial prefrontal cortex (mPFC) and its connections with the posterior dorsomedial striatum are implicated in goal-directed learning, but the spec
The pERKs of Temporal Order Memory in mice biorxiv.org 2026-07-03 Temporal Order Memory (TOM), the ability to discriminate between events according to when they occurred, is a key component of episodic-like memory.
Loss of the lncRNA SOX1-OT promotes p53-dependent cell-cycle arrest in astrocytes biorxiv.org 2026-07-03 Long non-coding RNAs (lncRNAs) are increasingly recognized as regulators of brain cell function, but their roles in astrocyte biology and neurodegener
Caloric restriction and intermittent fasting during lactation are linked to impaired maternal care, increased impulsivity and amygdala redox imbalance in dams biorxiv.org 2026-07-03 The lactational period requires substantial metabolic and behavioral adaptations, and more than 70% of mothers report weight concerns and attempt weig
Anticipatory organization of neural population dynamics speeds behavioral decisions biorxiv.org 2026-07-03 Expectations guide behavior and shape sensory responses in single neurons, but their influence on population-level neural dynamics is unknown.
A body-brain-behavioral cross-frequency architecture links biological and behavioral periodicities biorxiv.org 2026-07-03 Spontaneous behaviors, e.g., walking and speaking, are thought to rely on an internal sense of time that provides a scaffold for precise temporal coor
Complementary frontoparietal and corticothalamic contributions to relational reasoning biorxiv.org 2026-07-03 Complex reasoning depends on flexible coordination among frontal, parietal, and thalamic systems, but the circuit mechanisms that support increasing r
Impacts and interactions of stress, noradrenaline and serotonin signalling on probabilistic reversal learning biorxiv.org 2026-07-03 Rationale: Early life stress (ELS) is acknowledged to underlie cognitive and emotional abnormalities linked to stress-related mood disorders.