Competing Inter-Domain Quorum-Sensing Systems Control Prophage Lysis-Lysogeny Decisions biorxiv.org 2026-07-03 Phaeobacter inhibens T5T harbors three LuxI/LuxR quorum-sensing systems: one encoded by the host and one in each of two prophages.
Inhibition of Stemness Pathways during Acute SIV Limits Infection of Central Memory CD4+ T Cells and Alters Viral Reservoir Activity in Macaques biorxiv.org 2026-07-03 The establishment of a reservoir of latently infected CD4+ T cells that persist on antiretroviral therapy (ART) through proliferation represents the m
Initiation codon context governs translation-coupled mRNA decay and coordinated expression in the human parasite Leishmania biorxiv.org 2026-07-02 In the absence of canonical, promoter-based transcriptional regulation, Leishmania has evolved alternative regulatory mechanisms for adaptive gene exp
ProteoDUDes: Taxonomic profiling for metaproteomics with false positive reduction biorxiv.org 2026-07-02 Metaproteomics is the investigation of the protein composition of multi-organism samples.
Zero-Shot Metabolite Prediction from Gene Expression via Physics-Informed Graph Neural Networks biorxiv.org 2026-07-02 Predicting metabolite concentrations from gene expression is instrumental for linking regulatory programs to metabolic phenotypes.
WattmaMod enables high-resolution and extensible RNA modification profiling for nanopore direct RNA sequencing biorxiv.org 2026-07-02 Nanopore direct RNA sequencing enables direct profiling of RNA modifications on native transcripts, but accurate multi-modification detection remains
Near-Infrared II Scintillator for High-Resolution X-ray Imaging biorxiv.org 2026-07-02 Light scattering in scintillators is a pervasive problem and a key factor limiting X-ray imaging resolution.
Heterogeneous flux capacity and oxygen sensitivity lead to subcellular ETC flux gradients in mouse oocytes biorxiv.org 2026-07-02 Mitochondria are metabolic hubs of the cell that provide energy and metabolites to meet the energetic, biosynthetic and signaling demands of the cell.
Evaluation of Retinal Safety of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitors biorxiv.org 2026-07-02 Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors are widely used for the treatment of renal anemia; however, their effects on intraocul
Perceptual, metacognitive, and computational signatures of temporal landmark uncertainty in tactile motion perception biorxiv.org 2026-07-03 Motion perception depends on estimating the relative timing of sensory events under internal uncertainty.
Identification and quantification of neurological responses in patients with dentine hypersensitivity biorxiv.org 2026-07-02 Evaluation of the effectiveness of therapeutic interventions for dentine hypersensitivity is limited by a lack of standardisation and objectivity in m
Blinks are strategically coupled with head movements in unconstrained natural gaze behavior biorxiv.org 2026-07-02 Blinks are a ubiquitous yet largely unnoticed aspect of human vision, despite causing frequent interruptions of visual input that can amount to up to
1 Hz rTMS Is Not Inherently Inhibitory: Current Direction Determines Aftereffects and Reliability biorxiv.org 2026-07-02 Objective: Aftereffects of 1 Hz repetitive transcranial magnetic stimulation (rTMS) often differ within and between subjects and thus show low reliabi
Astrocytic morphology in the Medial Habenula: sex differences and modulatory factors biorxiv.org 2026-07-02 The medial habenula (MHb) is an epithalamic structure involved in aversive processing and emotional regulation, notable for its marked cellular hetero
Near-critical slow dynamics enable flexible temporal computations and generalization biorxiv.org 2026-07-02 Although neural activity often evolves along low-dimensional manifolds, such descriptions do not explain the dynamical mechanisms that generate, const
Spinal circuit regionalization diversifies motor output along the vertebrate body axis biorxiv.org 2026-07-02 The evolution of the vertebrate limb-torso-limb body plan drove a diversification of motor behavior.
Temporal fingerprints of TMS-evoked potentials across thalamocortical circuits biorxiv.org 2026-07-02 Background: Electroencephalographic (EEG) potentials evoked by transcranial magnetic stimulation (TMS) offer a direct window into cortical dynamics.
Mapping the immune landscape in small cell lung cancer unveils a distinct tumor-reactive CD8+ T cell molecular signature biorxiv.org 2026-07-03 Small cell lung cancer (SCLC) is a highly aggressive malignancy with limited therapeutic advances.
A Sensory Pathway Controls Motile Microcolony Formation and Spatial Organization in Gliding Bacteria biorxiv.org 2026-07-02 How motile bacteria navigating external surfaces convert environmental cues into transitions from dispersed states to cohesive, multicellular assembli
A Male Expressed Copulatory Plug Increases Female Fertility in Caenorhabditis Nematodes biorxiv.org 2026-07-03 The genomes of self-fertilizing hermaphrodites offer a unique opportunity to probe why some genes with sex-specific functions are lost while others ar
An open-access CT-based 3D anatomical dataset of extant sharks across all major lineages biorxiv.org 2026-07-02 Sharks exhibit extraordinary morphological diversity across a wide range of ecological niches, yet large-scale, high-resolution digital datasets of th
Conserved Genic Composition Unravels Rapid Karyotype Evolution and Polyploidization across Plants biorxiv.org 2026-07-02 Chromosomal variation underlies species evolution, but reconstructing its large-scale dynamics remains challenging, obscuring its adaptive significanc
Preclinical translation of Neurofibromatosis type 1 (NF1) exon 17 skipping using targeted U7-SnRNA packaged into engineered AAV serotypes. biorxiv.org 2026-07-02 To facilitate the translation of NF1 exon 17 skipping as a mutation-specific therapy for Neurofibromatosis type 1 into in vivo testing, we have contin
Scalable multi-group nonnegative spatial factorization for spatial genomics data with cell-type heterogeneity biorxiv.org 2026-07-03 Spatial transcriptomics (ST) technologies enable the study of gene expression within the spatial context of tissues, providing insights into tissue st
HiFi-ST: High-Fidelity Reconstruction of Continuous Spatial Transcriptomic Expression Fields via Conditional Neural Fields biorxiv.org 2026-07-02 Spatial transcriptomics characterizes tissue-scale gene expression patterns, yet its observations are sparse discrete samples of an underlying continu
A chromosome-level genome assembly of the Eurasian great grey owl, Strix nebulosa lapponica (Thunberg 1798) biorxiv.org 2026-07-02 We present a chromosome-level genome assembly of a female great grey owl (Strix nebulosa lapponica).
A Hall-Effect Sensor-Based Queen Bee Detection System -- a Proof of Concept biorxiv.org 2026-07-03 The queen bee is the central individual responsible for colony establishment, growth, and survival.
Simulating population pangenomes under coalescent demographic models with MSpangenome biorxiv.org 2026-07-03 Motivation: Pangenome variation graphs (PVGs) are increasingly used to represent genomic diversity, yet there is currently no general framework for ge
Inferring differentiation trajectories from T cell clonotype distributions biorxiv.org 2026-07-02 Single-cell RNA sequencing (scRNA-seq) enables reconstruction of cellular differentiation trajectories, but most trajectory inference methods rely lar
Programmable acoustic single cell manipulation with model-free machine learning biorxiv.org 2026-07-03 Precise, non-invasive manipulation of individual living cells remains a central challenge in biomedical science, with far-reaching implications for si