Mobile DNA Activity in Parkinson's Disease: A Locus-Specific View of Endogenous Retroviruses biorxiv.org 2026-07-03 Human endogenous retroviruses (HERVs) are mobile genetic sequences derived from ancient retroviral infections.
THE STRUCTURES OF MATURE AND IMMATURE ST. LOUIS ENCEPHALITIS VIRUS REVEAL CONSERVED HISTIDINE RESIDUES AFFECTING VIRUS FITNESS biorxiv.org 2026-07-03 Orthoflaviviruses undergo significant structural changes through maturation and infection, yet the molecular mechanisms remain incompletely understood
Replication fork directionality reveals how structural variants arise under replication stress biorxiv.org 2026-07-03 Structural variants (SVs) in cancer are associated with defects in DNA repair and replication stress, but the mechanisms generating common SV types re
Crowding on DNA modulates SSB protein binding mode kinetics biorxiv.org 2026-07-03 Single-stranded DNA-binding (SSB) proteins play a crucial role in DNA replication by binding to single-stranded DNA (ssDNA) in multiple binding modes,
A Comprehensive Evaluation of Protein Structure Prediction Models for Short Peptides biorxiv.org 2026-07-03 Short peptides pose distinct challenges for computational structural biology due to their lack of stable tertiary structures, high conformational flex
Nondual mindfulness meditation alters self representation and brain connectome in expert meditators biorxiv.org 2026-07-03 Nonduality is a foundational but conceptually elusive notion across several contemplative traditions.
Loss of HIF1α signaling drives oxidative stress and expansion of smooth muscle cells in murine atherosclerosis biorxiv.org 2026-07-03 Background: Hypoxia develops within growing atherosclerotic lesions, inducing nuclear translocation of hypoxia-inducible factor-1 (HIF1) and metabolic
Analysis of genetic variation in the bovine Mannose Receptor gene (MRC1), its influence on receptor expression, and a potential association with resistance to bovine tuberculosis biorxiv.org 2026-07-03 Naturally occurring variation in the bovine mannose receptor C-type 1 gene (MRC1) may shape macrophage responses to Mycobacterium (M.) bovis, a key dr
Carboxypeptidase activity drives L,D-transpeptidase essentiality during vegetative growth and sporulation in Clostridioides difficile biorxiv.org 2026-07-03 In most bacteria, peptidoglycan contains mainly 4-3 crosslinks formed by penicillin-binding proteins (PBPs).
Time-of-flight-resolved interferometric speckle-contrast optical spectroscopy (TOF-iSCOS) for depth-resolved blood-flow sensing biorxiv.org 2026-07-03 Significance: Continuous, noninvasive, and depth-resolved monitoring of blood-flow-related tissue dynamics remains an important unmet need.
Preserved Barrier Integrity and Altered Immune Profiles in Chronic Cannabis Users: Potential Roles of Δ9-Tetrahydrocannabinol biorxiv.org 2026-07-03 Although cannabinoids such as delta-9-tetrahydrocannabinol (THC) are generally immunosuppressive in preclinical models, chronic cannabis use in humans
The illusion of diversity: sampling design drives conflicting estimates of soil bacterial richness biorxiv.org 2026-07-03 Soil microbial diversity is shaped by the spatial scale at which communities are sampled, yet standard sampling practices often homogenize samples, ob
The Hunt for Cholesteryl Ester Hydrolases: Identification of Lipoprotein Lipase as a Cholesterylesterase biorxiv.org 2026-07-03 Cholesteryl esters (CEs) are central intermediates in cholesterol storage and transport, yet the enzymes responsible for their hydrolysis in mammals r
Analyte-Class-Dependent Electrophoretic Organization Enables Single-Run Proteome-Metabolome Analysis by CE-ESI-MS biorxiv.org 2026-07-03 Dual proteome-metabolome measurements from limited samples typically require sample splitting or sequential analyses using electrospray ionization mas
Internalized Components of Membrane Attack Complexes Disrupt Proteostasis and Acquire Alarmin-Like Properties biorxiv.org 2026-07-03 Immune effects of membrane attack complexes (MAC) have been widely attributed to their abilities to cause cell death.
Unveiling Cerebrospinal Fluid Protein Biomarkers in Pediatric Acute Lymphoblastic Leukemia Using Proximity Extension Assay biorxiv.org 2026-07-03 Abstract Background: Acute Lymphoblastic Leukemia (ALL) is a highly heterogeneous pediatric malignancy.
Conservation and evolution of the ribosome across the photosynthetic lineage biorxiv.org 2026-07-03 Regulated biogenesis of photosynthetic proteins by the chloroplast ribosomes is central to plant development and environmental adaptation.
Contextualised real-time mass spectrometry improves glycosylation detection and characterisation biorxiv.org 2026-07-03 Glycosylation is a structurally diverse, non-template-driven modification whose analysis by liquid chromatography-mass spectrometry is constrained by
L-5--glutamine PET of Breast Cancer: Kinetic Analysis in Mouse Models to Evaluate Glutamine Metabolism biorxiv.org 2026-07-03 Abstract (250 words) Background: Glutamine addiction is a hallmark of aggressive tumors, yet glutaminase (GLS1) inhibitor CB-839 showed disappointing
Adenosine A2B Receptor Activation: A Novel Therapeutic Strategy for Accelerating Liver Recovery After Acetaminophen Overdose biorxiv.org 2026-07-03 An acetaminophen (APAP) overdose is the leading cause of drug-induced hepatotoxicity and acute liver failure (ALF) in the United States.
Plasma metabolite responses to an oral protein tolerance test differ between young and sarcopenic participants and suggest altered anabolic sensitivity biorxiv.org 2026-07-03 Abstract Background: Sarcopenia is associated with anabolic resistance, a blunted muscle protein synthesis response to protein ingestion.
Charge-trap flash memory cells of the brain biorxiv.org 2026-07-03 Despite extensive study of cellular mechanisms underlying long-term potentiation, no single specific protein or gene has been identified which encodes
Aging reveals domain-specific vulnerability to the chronic behavioral consequences of repetitive mild traumatic brain injury biorxiv.org 2026-07-03 Older adults are among the fastest growing groups of traumatic brain injury (TBI) patients and sustain disproportionately poor chronic outcomes.
Somatosensory gating dysfunction is masked by cognitive variability in cognitively impaired individuals biorxiv.org 2026-07-03 Disruptions in somatosensory processing have been observed in cognitive impairment (CI), suggesting that alterations in sensory processing may emerge
Eyes on the prize: Mice deploy task-driven saccades during naturalistic foraging biorxiv.org 2026-07-03 Active sensing allows organisms to shape incoming sensory information through self-generated actions, and saccadic eye movements provide a key readout
200 years of river engineering: changes in meta-ecosystem resilience and connectivity biorxiv.org 2026-07-03 This study investigates changes in habitat connectivity and meta-ecosystem resilience between 1817 and 2022 along a 150 km section of a large European
Pangenome-based human genome analysis improves trait association and genomic prediction biorxiv.org 2026-07-03 The Human Pangenome Reference Consortium has generated 462 open-access reference genomes and a variation graph that represents differences among them,
Selective and Efficient Functionalization of P22 Virus-Like Particles Using an Asparaginyl Ligase biorxiv.org 2026-07-03 Protein cages provide useful scaffolds for nanoscale engineering due to their highly ordered structures and in vivo self-assembly.
RD-OMICS: An Integrative Multi-Omics Data Inventory in Rare Diseases biorxiv.org 2026-07-03 Rare diseases (RD) impact over 30 million individuals in the United States, yet fewer than 5% of the identified conditions have FDA-approved treatment
Structural Organization of the Nvj3-Mdm1 Complex Reveals a Conserved Lipid-Compatible Contact Site Module biorxiv.org 2026-07-03 Membrane contact sites are organized by protein assemblies that physically couple organelles and coordinate lipid metabolism, yet the structural princ