Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation biorxiv.org 2026-07-03 The human thalamus is composed of multiple nuclei that differ in structure and function.
Rapid value learning reveals generalized and context-dependent codes in frontal cortex biorxiv.org 2026-07-03 Studying how the brain represents value spans distinct methods and training histories, from neuroimaging in task-naive humans to single-neuron recordi
Multi-Site Reproducibility Study of 3D High-Content Analysis with Dual-View Oblique Plane Microscopy biorxiv.org 2026-07-03 High content imaging is being applied to achieve quantitative fluorescence readouts in increasingly complex 3-dimensional (3D) cell culture models suc
Segmentation and classification of retinal pigment granules in fluorescence lifetime imaging microscopy (FLIM) data biorxiv.org 2026-07-03 Alterations of fluorescence properties in retinal pigment epithelium (RPE) cells caused by diseases such as age-related macular degeneration (AMD) hig
Quantifying Asymmetric Coevolutionary Dynamics using Normalized Phylogenetic Costs biorxiv.org 2026-07-03 Coevolutionary studies aim to characterize associations, such as virus-host relationships, by using phylogenetic distances to quantify the topological
Females Adapt to Dietary Protein Restriction on Enhanced Gut-Brain Axis during Aging biorxiv.org 2026-07-03 Growing evidence supports a critical role for the gut-brain axis in regulating metabolic health, inflammation,and cognitive function during aging.
P-DOpE probes reveal local amplification of phasic noradrenergic release in the hippocampus biorxiv.org 2026-07-03 Fiber photometry (FP) has become a tool of choice for in vivo monitoring of genetically encoded biosensors.
Modelling sterilisation strategies to maximise population impact and cost-efficiency in free-roaming dog populations biorxiv.org 2026-07-03 Free-roaming dog populations pose challenges to public health and animal welfare, and their management and protection is legally mandated in many coun
Interspecies Differential Gene Expression Analysis with Regularized Phylogenetic Linear Models biorxiv.org 2026-07-03 Comparative transcriptomic datasets are increasingly used to investigate the molecular basis of phenotypic diversification across species.
Model-free inference of evolution from allele frequency timeseries using permutation tests biorxiv.org 2026-07-03 Allele frequency (AF) timeseries allow us to directly observe the dynamics of evolution at a genetic level.
Rare sex punctuates strict asexual reproduction in the clonal raider ant, Ooceraea biroi biorxiv.org 2026-07-03 While asexual species can often outcompete their sexual counterparts over ecological timescales, their long-term evolutionary success is hindered by a
Negative Autoregulation Promotes the Evolution of Strong Environmental Switching biorxiv.org 2026-07-03 Living systems rely on gene regulatory circuits to respond to environmental change.
Ancestral gene flow shaped the singular origin of the Amazon molly biorxiv.org 2026-07-03 The evolutionary origins of asexuality remain poorly understood, despite extensive research on its ecological and evolutionary consequences.
Across Species Identification of Genes Bridging Cognition and Reproduction biorxiv.org 2026-07-03 Evolutionary success in mammals requires coordinated regulation of cognitive functions and reproductive capacity.
Anthropogenic effects, not climatic, shaped Holocene population expansion of an insular bee fauna biorxiv.org 2026-07-03 Remote island systems with small landmasses and reliable estimates of human occupancy are ideal model systems to disentangle the roles of global clima
Emergence of histone-based chromatin complexity in Asgard archaea biorxiv.org 2026-07-03 The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that cons
Evidence for the 1/e-law predicting optimal timing of reproduction across taxa biorxiv.org 2026-07-03 Reproductive success requires allocating effort across lifespan in a manner that balances the risk of early mortality against the benefit of higher fe
Drug Functional Site-Unknown Molecular Targets Exemplified by SARS-CoV-2 pseudoknot and ribosomal frameshifting-modulators biorxiv.org 2026-07-03 The -1 Programmed Ribosomal Frameshifting (-1 PRF) signal of SARS-CoV-2, driven by a conserved three-stemmed RNA pseudoknot (PK), is indispensable for
ViralEpiBase: a manually curated repository of epitranscriptomic modification sites across viral RNA genomes and virus-encoded transcripts biorxiv.org 2026-07-03 Post-transcriptional chemical modifications of RNA, collectively termed the epitranscriptome, have emerged as critical regulatory layers governing vir
Protein Surface Site Determines the Evolutionary Accessibility of Allosteric Regulation biorxiv.org 2026-07-03 Domain recombination is a major source of new allosteric regulation in both evolved and engineered proteins.
A Minimal Stochastic Model of Microbial Ecological Dynamics in a Single-Species-Single-Resource Setting biorxiv.org 2026-07-03 Microbes exhibit complex dynamic behavior as the result of a large number of biochemical processes, spatial and temporal interactions, environmental v
Supershoes or Superhumans? A controlled analysis of sex-specific road-running performance evolution in the era of advanced footwear technology biorxiv.org 2026-07-03 Advanced footwear technology (AFT) improves running economy and is widely credited with recent performance improvements in road running, with observat
Distinct RNA engagements define genome import and replication elongation in alphaviruses biorxiv.org 2026-07-03 Membrane-associated replication complexes (RCs) are a hallmark of alphaviruses, yet the mechanisms by which viral RNA is delivered into these compartm
Clade 2.3.4.4b H5N1 influenza virus and SARS-CoV-2 seroprevalence among owned and feral cats in Philadelphia and surrounding communities biorxiv.org 2026-07-03 Clade 2.3.4.4b H5NX influenza viruses have spread widely in birds since 2020.
Dysregulation of pupal diapause in hybrid progenies, introgression and species delimitation within and beyond the Old World Swallowtail (Papilio machaon Linnaeus) butterfly complex biorxiv.org 2026-07-03 In search of recurrent patterns of postzygotic hybrid incompatibility, we investigated the Holarctic 'Old World Swallowtail' (Papilio machaon Linnaeus
Heat stress drives opposing redox shifts in temperate versus tropical Drosophila melanogaster embryos biorxiv.org 2026-07-03 Redox balance is central to aerobic metabolism, yet acute heat stress can destabilize this balance by increasing metabolic rates and shifting the bala
Evolution of mutation rates in digital genomes: the roles of genetic drift, mutational supply, and genome size biorxiv.org 2026-07-03 Mutation is the ultimate mechanism that produces genetic novelty, and thus a central ingredient of evolution.
Asymmetric migration shapes genetic structure of the invasive avian vampire fly (Philornis downsi) across the Galapagos Islands. biorxiv.org 2026-07-03 Biological invasions on islands provide a natural framework to study how dispersal and connectivity influence evolutionary and ecological processes.
Climate-driven fitness decline in Japanese chum salmon reshapes North Pacific chum salmon biogeography biorxiv.org 2026-07-03 Japanese chum salmon supported by one of the world largest hatchery programs have experienced severe declines in marine survival and egg size.
Ecological genomics of a novel host-parasitoid arms-race in nature biorxiv.org 2026-07-03 Novel antagonistic interactions between species are expected to drive especially rapid coevolution.