Drosben, an affordable system for scalable survival analysis in Drosophila biorxiv.org 2026-07-06 Survival analysis is a workhorse assay in Drosophila research to evaluate somatic fitness.
Increased CA3 burst activity in Doc2α and Syt7 knockout mice biorxiv.org 2026-07-06 The hippocampal CA3 subfield is central to associative learning and memory consolidation.
Symbiotic yeasts of a bark beetle transform major tree defenses into beetle protectants biorxiv.org 2026-07-06 The Eurasian spruce bark beetle Ips typographus, a major forest pest on Norway spruce (Picea abies), forms intimate associations with several types of
The Microglial Protein sTREM2 Inhibits the Bacterial Functional Amyloid CsgA and Suppresses Amyloid-Dependent Biofilm Formation biorxiv.org 2026-07-06 Protein misfolding and aggregation, including amyloid fibril formation, underlie a large class of human diseases including prominent neurological diso
The anaerobic cryo-EM structure of the methanogenic Mtr complex reveals a nitrogenase-like cluster bound to its active site biorxiv.org 2026-07-06 Methanogenic archaea conserve energy by coupling methyl-group transfer to the generation of a chemiosmotic sodium-ion (Na+) gradient.
A control-validated pan-proteome deep-learning pipeline nominates GPR35 as a candidate target of the orphan bacterial metabolite ligiamycin A biorxiv.org 2026-07-06 Most microbial natural products with documented bioactivity lack an identified molecular target, which limits their development.
Platelet GARP-dependent activation of TGF-β1 limits inflammation and promotes cardiac repair after myocardial infarction biorxiv.org 2026-07-06 Platelets are increasingly recognized as active regulators of inflammation beyond their canonical hemostatic functions.
CatESO: Differentiable Enzyme Sequence Optimization Guided by Substrate-Aware kcat Prediction biorxiv.org 2026-07-06 Enzymes drive biological chemistry and offer greener routes to chemicals, materials and medicines, yet their broader use as biocatalysts is often limi
Fibroblasts impair muscle stem cell self-renewal via excessive fibronectin deposition in viscoelastic hydrogel co-cultures biorxiv.org 2026-07-06 Muscle satellite cells (SCs) regenerate skeletal muscle, but their regenerative capacity declines with age, in part due to extracellular matrix (ECM)
Residual Hair Biomaterial Particulates Improve Dermal Regeneration and Combined with Electrical Stimulation Accelerates Skin Wound Closure biorxiv.org 2026-07-06 Objective: To evaluate the effect of residual hair (RH) biomaterial particulates, biphasic electrical stimulation (ES), and their combination (RHES) o
Comparative assessment of gene drive release patterns and spread with a hex-based model for large-scale simulations biorxiv.org 2026-07-06 Spatial population genetic and ecological modeling is often necessary to predict outcomes accurately.
Biodiversity knowledge and conservation shortfalls in Rivulidae fishes biorxiv.org 2026-07-06 The biodiversity crisis is exacerbated by persistent gaps in taxonomic, geographic, and conservation knowledge.
'Who Goes There?' Quantifying Scavenger-Carcass Activity at Mass Mortality Events biorxiv.org 2026-07-06 Mass mortality events (MMEs) create sudden pulses of carrion that can alter how vertebrate scavengers use carcass resources, including the frequency,
Anthropogenic subsidies reshape Ruby-throated Hummingbird (Archilochus colubris) interactions across spatial and temporal contexts: evidence from community-collected data biorxiv.org 2026-07-06 1. Ruby-throated hummingbirds (Archilochus colubris) exhibit flower preferences and readily visit human subsidies like feeders.
Stereoselective Covalent Targeting of BTK(C481S) and Kinases with β-Lactone Electrophiles biorxiv.org 2026-07-06 The cysteine to serine mutation at residue 481 of Bruton's tyrosine kinase (BTK) is the most common mechanism of clinical resistance against ibrutinib
Combined computational and experimental analysis confirm donor-dependent optimization of critical processing parameters for improving mesenchymal stromal cell potency and expansion attributes biorxiv.org 2026-07-06 Mesenchymal Stromal Cells (MSC) face several heterogeneity challenges hindering clinical and commercial success.
Water as a thermal contrast agent for artificial-intelligence-enhanced in vivo mid-infrared thermography biorxiv.org 2026-07-06 In vivo infrared thermography is limited by the inherently poor spatial resolution at long wavelengths, low contrast, and the lack of biocompatible co
Estimating Body Segment Properties for Adults AcrossDiverse Body Morphologies: A Data-Driven GeometricFramework biorxiv.org 2026-07-06 Accurate estimation of body segment inertial properties is essential for biomechanical analyses, yet commonly used scaling methods rely on limited dat
Shared Genomic Architecture Between Schizophrenia and Multiple Sclerosis Identifies an Un-Drugged HCAR1 Neuroimmune Checkpoint biorxiv.org 2026-07-05 Multiple Sclerosis (MS) pathogenesis is contingent upon the hyper-proliferative infiltration of peripheral macrophages across the blood-brain barrier.
Engineering CAR T Cells for Hepatocellular Carcinoma Recurrence after Liver Transplantation biorxiv.org 2026-07-05 Background & Aims: Liver transplantation improves outcomes in hepatocellular carcinoma (HCC), yet treatment options for patients with tumor recurr
How Robust are Multispecies Coalescent Species Delimitations in Taxonomically Complex Systems? A Genomic Assessment Using Mediterranean Tethya Sponges biorxiv.org 2026-07-05 Reliable species delimitation underpins biodiversity assessment but remains difficult for organisms with plastic morphology and few diagnostic charact
CellTFusion: a transcriptional regulatory network framework for the identification of functional multicellular states from bulk RNA-seq data biorxiv.org 2026-07-05 Bulk RNA-seq remains the most accessible transcriptomic platform for tumor microenvironment (TME) characterization, yet existing computational approac
ADMET Property Prediction with Quantum-Inspired Preprocessing biorxiv.org 2026-07-05 Accurate prediction of Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties is a central challenge in early-stage drug dis
Trinucleotide Distribution, Symmetry Elements and Formulation of Mirror Symmetry Index for G4 Motifs biorxiv.org 2026-07-05 Symmetry elements in nucleic acids are most strongly correlated with sites of biological function; however, their relevance to non-canonical structure
Deciphering the Tumor Microenvironment: An Integrated Single-Cell RNA-Seq and AI Framework for Novel Biomarker and Therapeutic Target Discovery in Melanoma biorxiv.org 2026-07-05 Background: Melanoma represents a highly immunogenic and therapeutically challenging malignancy.
Real-time mass defect-driven prediction of glycopeptide precursors enables enrichment-free serum glycoproteomics biorxiv.org 2026-07-05 Glycopeptide enrichment remains a cornerstone in glycoproteomics, but bias and reproducibility issues continue to hinder biological insight and clinic
Tissue tearing degrades optimal-transport and diffeomorphic registration of spatial transcriptomics beyond displacement magnitude: a multi-seed deformation benchmark and a supervised graph cross-attention proof-of-concept. biorxiv.org 2026-07-05 Background.
Conformational changes induced in ubiquitin by circular protein-DNA chimeras biorxiv.org 2026-07-05 Proteins are dynamic molecular machines that change shape in response to physical and chemical perturbations.
Rheostatic Network Consolidation Drives Physical Aging in Biomolecular Condensates biorxiv.org 2026-07-05 While the physical aging of biomolecular condensates into macroscopic glasses is heavily linked to pathological disease states, the nanoscale topologi
Aquatic respiratory rates in red devil vampire crabs (Geosesarma hagen) are dependent on interactions between temperature, sex, and body size biorxiv.org 2026-07-05 The shift to terrestrial environments in ancestrally aquatic animals is often associated with key physiological and physical changes, including shifts