DNA-SIP reveals salinity-associated niche differentiation of potentially active methanogens in mangrove soils biorxiv.org 2026-07-06 Mangrove forests are major blue carbon ecosystems but are often characterized by low surface methane (CH4) emissions.
SARS-CoV-2 Spike H655Y drives protease preference but does not dictate cellular tropism biorxiv.org 2026-07-06 Throughout the COVID-19 pandemic, SARS-CoV-2 has undergone rapid adaptation, with the Omicron variant exhibiting an unexpected shift towards upper air
It takes two: A Widespread Temperate Bacteriophage Contributes to Regulation of the Type III Secretion System in Pseudomonas syringae biorxiv.org 2026-07-06 The Pseudomonas syringae species complex includes major crop pathogens that use a type III secretion system (T3SS) to inject effectors into plant cell
Horizontal gene transfer drives DNRA capacity in wastewater treatment systems biorxiv.org 2026-07-06 Dissimilatory nitrate reduction to ammonium (DNRA) is a key biological nitrogen retention pathway, yet the evolutionary mechanisms remain poorly under
Widespread immune systems protect bacteria against conjugative plasmids biorxiv.org 2026-07-06 Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells.
Comparative analyses of Gram-negative bacteria isolated from cancer patients with bacteraemia at the Uganda Cancer Institute biorxiv.org 2026-07-06 Antimicrobial resistance (AMR) exacerbates bacteraemia in cancer patients, particularly in low-resource settings.
RulePep: Interpretable ESM-Guided Neural-Symbolic Peptide Classification biorxiv.org 2026-07-06 Peptides are increasingly explored as therapeutic candidates, delivery vectors, and functional biomolecules, but experimental screening of peptide act
Transfer learning reveals species-specific olfactory preferences in Diptera and informs pest management strategies biorxiv.org 2026-07-06 The interaction between volatile organic compounds (VOCs) and odorant receptors (ORs), termed VOI, constitutes the molecular basis for species to reco
A generalisable framework to inject distance information into Alphafold-like structure predictors biorxiv.org 2026-07-06 Structure prediction methods are now highly successful at predicting three-dimensional structures from sequence.
Multivalent Surface Search Dynamics Shape Bacteriophage Adsorption Efficiency: A Stochastic Model of Tail Fiber Optimization biorxiv.org 2026-07-06 Phages must locate and bind to bacterial surface receptors to initiate infection. Their tail fiber configuration critically influences this process.
Standardizing image-derived fish length-frequency distributions to reference measurements using bin-specific error matrices biorxiv.org 2026-07-06 Artificial intelligence (AI)-based image analysis can efficiently estimate fish length, but differences in devices, imaging conditions, operators, and
Northward expansion of the barnacle Fistulobalanus albicostatus in Japan biorxiv.org 2026-07-06 Fistulobalanus albicostatus Pilsbry, 1916 (Thoracica: Balanidae) is a tropical to temperate species distributed in the NW Pacific.
There is no silver bullet: Tiger corridors do not ensure multispecies carnivore connectivity biorxiv.org 2026-07-06 Connectivity is critical to sustaining endangered carnivores in speciose yet fragmented landscapes such as in the global south.
A Raman Spectroscopy-Based Method for Label-Free Discrimination of Human Inhibin α, Inhibin B, and Activin A biorxiv.org 2026-07-06 Members of the transforming growth factor-{beta} (TGF-{beta}) superfamily, including inhibins and activins, are structurally related glycoprotein dime
Glia mediate brain-wide activity and sleep behavior during sickness through an adrenergic-glutamatergic axis biorxiv.org 2026-07-06 Sickness induces coordinated changes in physiology and behavior, but despite the identification of circuits that underlie specific aspects of sickness
DELPHAI predicts heterogeneous perturbation responses with learned cell fitness and gene-space retrieval biorxiv.org 2026-07-06 Modelling heterogeneous cellular responses to perturbation holds the promise of scalable in silico screening and mechanistic insight.
PEPstrMOD2: Next-generation tertiary structure prediction of chemically modified and non-natural peptides biorxiv.org 2026-07-06 While most existing methods are limited to predicting the tertiary structures of proteins containing only canonical residues, the PEPstrMOD server (de
Targeting DNMT1 augments anti-tumor CD8⁺ T cell function biorxiv.org 2026-07-06 Chronic stimulation of CD8 T cells within the tumor microenvironment (TME) induces a hypofunctional state characterized by diminished cytotoxicity and
Kappa opioid receptors in excitatory spinal neurons gate acute pain: evidence from mouse and human biorxiv.org 2026-07-06 The kappa opioid receptor (KOR) has emerged as a promising, nonaddictive analgesic target, yet the neural mechanisms underlying KOR inhibition of pain
Brain Regions Involved in Object-Location Memory Across the Human Lifespan: A Systematic Review and Activation Likelihood Estimation Meta-Analysis of Task-Based fMRI biorxiv.org 2026-07-06 Background: The ability to remember object locations in real life is a fundamental cognitive process that supports goal-directed behavior and is parti
Longitudinal Salivary Immunophenotyping Reveals Distinct Cellular Signatures of Periodontal Disease Activity and Resolution biorxiv.org 2026-07-06 Aim: To investigate whether salivary immune cell profiling can serve as a non-invasive approach to monitor periodontal disease activity and therapeuti
A Conserved Chromatin-Driven Checkpoint Defines Late Macrophage Maturation Independent of Tissue Specialization biorxiv.org 2026-07-06 Macrophage identity is widely viewed as a product of ontogeny and tissue-specific imprinting.
Detecting domain-level organization in genome-wide association study summary statistics using frequency-impact-reliability profiles biorxiv.org 2026-07-06 Genome-wide association studies (GWAS) identify trait-associated variants but are typically interpreted through single-variant significance and locus-
Model of naturally occurring refractive error (NORE) in mice biorxiv.org 2026-07-06 Purpose: Animal models of myopia typically induce monocular refractive shifts via form deprivation (FD) or lens-induced myopia (LIM), modeling suscept
Enhancing predictive accuracy of yield traits in cassava through multi-trait genomic prediction biorxiv.org 2026-07-06 Multi-trait genomic prediction offers a practical route to improve selection for costly, complex traits in clonally propagated crops such as cassava.
Accelerated Measurement of Chemical Exchange Saturation Transfer by Accordion NMR Spectroscopy biorxiv.org 2026-07-06 Chemical exchange saturation transfer (CEST) has become an indispensable NMR method to characterize slow exchange affecting biomacromolecules, especia
Actors' Facial Movement Magnitude and Cardiac Dynamics Predict Observers' Emotion Believability Ratings biorxiv.org 2026-07-06 In non-verbal communication, observers infer emotions from visible facial movements, yet emotional experiences are described in internal bodily terms
Unimanual fatigue increases muscle excitation and local metabolic activity in the resting contralateral forearm biorxiv.org 2026-07-06 Intense unilateral muscle contractions evoke measurable activity within the contralateral neuroaxis, which can be detected with surface electromyograp
Automated auditory brainstem response peak estimation using a convolutional neural net biorxiv.org 2026-07-06 Auditory brainstem responses (ABRs) are a core part of objective functional evaluations of hearing sensitivity and subcortical auditory transmission.
Meditation Depth Enhances the Functional Signal-to-Noise Ratio of the Brain biorxiv.org 2026-07-06 Across contemplative traditions, deeper states of meditation are described as states of heightened clarity, vividness, and stillness of mind, yet what