Topological data analysis captures complex behavioral dynamics during naturalistic social interaction between domestic ferrets biorxiv.org 2026-07-07 Capturing naturalistic behavioral dynamics is essential for understanding social interaction in ecologically valid settings.
Genome editing of marsupial RSX reveals conserved and divergent principles in mammalian X-inactivation biorxiv.org 2026-07-07 X-chromosome inactivation balances X-gene dosage between the sexes in eutherians and marsupials.
TrustPGS: When can a polygenic score be trusted? A per-individual reliability framework across ancestries biorxiv.org 2026-07-07 Polygenic scores summarise genetic predisposition to a trait, but a population-level accuracy figure cannot tell a clinician whether a given predictio
Determinants of Blood Group Antigen Expression and Prediction of Phenotypes by Machine Learning biorxiv.org 2026-07-07 Blood group antigens, defined by epitopes on the erythrocyte surface, are central to transfusion safety and maternal-fetal compatibility.
A Requirement for K+ Ion Dehydration Governs Gating of the Shaker K+ Channel: Quantum Calculations Show Complex Interactions of Ions, Water, Protons, and Protein Side Chains biorxiv.org 2026-07-07 There is a vast literature on the voltage gating of ion channels, with a fairly large fraction concerned with potassium channels, especially of the KV
ScaleSurfer: multi-scale anatomical segmentation and parcellation of the human brain biorxiv.org 2026-07-07 Human brain magnetic resonance imaging (MRI) revolutionized our ability to non-invasively probe individual differences in neuroanatomy.
Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs biorxiv.org 2026-07-07 Sensory neurons encode information about external stimuli in the form of stimulus-specific patterns of activity across their population.
Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulation biorxiv.org 2026-07-07 Exogenous opioids that activate mu-opioid receptors (MORs) in nociceptive circuits mediate transient pain relief lasting minutes to hours but have mor
Walking in circles: Linking high- and low-level parameter scaling of visually guided and spontaneous turning behaviour biorxiv.org 2026-07-07 The ability of animals to adjust their heading, i.e. to turn, is essential for all walking animals.
Spatial lung niches shape Pseudomonas aeruginosa persistence biorxiv.org 2026-07-07 Chronic Pseudomonas aeruginosa lung infection is a major cause of morbidity and mortality in people with pre-existing lung disease.
Nuclear adenosine metabolism defines a metabolic vulnerability unmasked by TP53 loss biorxiv.org 2026-07-07 Metabolic adaptation is essential for cells experiencing chronic genomic stress, yet how such adaptations are organized at the nuclear level remains p
Distinct colorectal cancer genotypes shape microbial ecosystems and reveal stage-specific microbiota dependencies biorxiv.org 2026-07-07 The gut microbiota has emerged as an important modifier of colorectal cancer (CRC), yet how tumor genotype influences host-microbiota interactions and
Targeting folate-dependent purine synthesis sensitizes melanoma cells to immune attack through suppressing glycolysis biorxiv.org 2026-07-07 Cytotoxic T lymphocytes (CTLs) play a central role in antitumor immunity; however, metabolic reprogramming within the tumor microenvironment often com
Metallothionein loss in cancer cells contributes to increased mutations through defective DNA repair and metabolic imbalance biorxiv.org 2026-07-07 Understanding which genes are involved in mutagenesis is essential for developing cancer prevention and treatment strategies; establishing protectors
Cysteine-mediated bortezomib resistance is governed by α-ketoacid availability biorxiv.org 2026-07-07 Dissecting how metabolite availability impacts drug sensitivity is critical for understanding therapy resistance.
LsGCRPred: lncRNA-SNP regulated gene expression-based breast and ovarian cancer risk prediction model biorxiv.org 2026-07-07 Long non-coding RNAs (lncRNAs) and single nucleotide polymorphisms (SNPs) within them play crucial role in cancer susceptibility and disease outcomes.
Dosimetric Characterization and Workflow Optimization of the FLASH-SARRP for Reliable Preclinical Radiobiological Studies biorxiv.org 2026-07-07 Objective: Preclinical small-animal irradiators such as the FLASH-SARRP can support the advancement of photon-FLASH toward the clinic.
From Phenomics to Genomics: Macro-GWAS of Almond Morphology and Quality biorxiv.org 2026-07-07 In plant breeding and genetics, recent advances in high-throughput phenotyping are beginning to meet the growing demand for large-scale, high-quality
Mineral geochemistry and mycorrhizal allocation define root architectural strategy during early vascular plant colonization biorxiv.org 2026-07-07 The emergence of vascular plants on land is one of evolution greatest triumphs.
Specialized layer 5 cortical terminals target functional thalamic spines biorxiv.org 2026-07-07 Dendritic spines are ubiquitous morpho-functional elements of excitatory synaptic transmission and plasticity.
Trisomy 21 cerebral organoids exhibit Alzheimer's disease amyloid and apolipoprotein E co-pathologies biorxiv.org 2026-07-07 Adults with Down syndrome (DS) develop Alzheimer's disease (AD) brain pathology by age 40 due to triplication of the Amyloid Precursor Protein (APP) g
Structural connectivity of auditory-linguistic brain networks predicts success in speech categorization and listening in noise biorxiv.org 2026-07-07 Successful speech perception requires listeners to bin continuous acoustic information into discrete phonetic categories.
Selective convergence and graded divergence of hippocampal and amygdala subregions using functional connectivity biorxiv.org 2026-07-07 The hippocampus and amygdala are neighboring medial temporal lobe structures linked to memory and affect, yet how their subregions are jointly embedde
FCRL5 is a fucose-sensitive IgG-Fc receptor with binding properties distinct from classical Fcγ receptors biorxiv.org 2026-07-07 Fc receptor-like protein 5 (FCRL5) is a low-affinity IgG receptor expressed on B cells, with emerging therapeutic relevance due to its expression on m
A Multidimensional Analysis of the Bimodal Piperaquine Response in Plasmodium falciparum biorxiv.org 2026-07-07 Malaria remains a pressing global health challenge, with the continued emergence of resistance threatening the long-term efficacy of artemisinin-based
SLC16A6 is a tyrosine transporter for the melanosome biorxiv.org 2026-07-07 Cells enable specialized metabolism by compartmentalizing metabolic pathways into distinct organelles, which requires the membrane transport of metabo
Unbranched SPIN90-Arp2/3 actin promotes stress fiber speed and focal adhesion maturation biorxiv.org 2026-07-07 The Arp2/3 complex has long been considered to only assemble branched actin structures in the cell (lamellipodia, endocytic patches, comet tails, and
ATG-9-Induced Lysosomal Membrane Permeabilization and Cell Death in a Caenorhabditis elegans model of Mucolipidosis type IV biorxiv.org 2026-07-07 Mucolipidosis type IV is a lysosomal storage disease that is characterized by delayed psychomotor development and retinal degeneration due to cell dea
Structural Mechanism of Filamentation Induced Dampening of GTP Inhibition of Glutamate Dehydrogenase biorxiv.org 2026-07-07 Glutamate dehydrogenase (GDH) is a highly regulated key enzyme that catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate
An allosteric pocket in KV1.3 defines a distinct chemical space for immunomodulator design biorxiv.org 2026-07-07 KV1.3 is a validated autoimmune drug target, yet all disclosed inhibitors converge on a narrow set of conserved binding sites, suffering from poor sel