Nemo2.4: fast and accurate quantitative genetics forward-time simulations biorxiv.org 2026-07-08 We present Nemo 2.4, an advanced forward-time individual-based simulation framework designed to model the complex eco-evolutionary dynamics and geneti
Flavin cycling under prebiotic conditions: bidirectional electron transfer and versatility in nickel and iron containing environments biorxiv.org 2026-07-08 Flavins are organic redox cofactors central to metabolism and uniquely capable of acting as extracellular electron shuttles.
Hydrodynamic shear enables enrichment of functional tumor antigen-reactive T cells biorxiv.org 2026-07-08 Adoptive T-cell therapies rely on the identification and expansion of rare tumor-reactive T cells, yet current enrichment strategies are limited by th
Bifidobacterium pseudocatenulatum extracellular vesicles promote Ly6G+ granulocyte infiltration to inhibit melanoma tumour progression biorxiv.org 2026-07-08 Harnessing the immunomodulatory capacity of commensal bacteria is an emerging avenue in cancer therapy.
S100A9-Dependent CXCR2hi Neutrophils Mediate Systemic Immune Suppression and Checkpoint Resistance in Metastatic TNBC biorxiv.org 2026-07-08 Most high-dimensional studies of tumor-immune interactions focus on metastatic models, limiting insight into how immune remodeling in primary tumors s
A spatiotemporal single-cell atlas reveals coordinated immune, metabolic, and nutrient exchange programs and a coumarin-centered metabolic switch during soybean arbusular mycorrhizal symbiosis biorxiv.org 2026-07-08 Arbuscular mycorrhizal fungi (AMF) establish intimate symbiosis with plant roots, yet the cell-type-specific regulatory and metabolic programs governi
UstiGate: Next generation toolkit for advanced genetic engineering of the basidiomycete chassis Ustilago maydis biorxiv.org 2026-07-08 BackgroundThe corn smut fungus Ustilago maydis is an important microbial model organism representing a genetically amenable and readily cultivable bas
Dissociating representations of object shape, real-world size, and mobility in human visual cortex biorxiv.org 2026-07-08 Object representations in the human ventral occipitotemporal cortex (VOTC) are organized along multiple dimensions, including shape (rectilinear vs.
A DNA mass conservation mechanism underpins cellular mtDNA number regulation biorxiv.org 2026-07-08 The nucleoid, which houses mtDNA within the mitochondrial matrix, is a phase-separation-driven biomolecular condensate capable of carrying out a broad
MYC2 mediated regulation of xylan substitution patterns biorxiv.org 2026-07-08 O-Acetylation is the most abundant xylan decoration in eudicot plants and plays a critical role in determining xylan conformation and its interactions
Pathogenic DRP1 variants reveal a role for biomolecular condensation in mitochondrial fission biorxiv.org 2026-07-08 Fission is essential for proper mitochondrial function and for cellular homeostasis.
Generative Drug Design in a Loop with dtSFM biorxiv.org 2026-07-08 Directed evolution consisting of iterative rounds of diversification, selection, and counter-selection, underlies modern protein and antibody engineer
Multilayered specificity of transcription factor binding at cytokine promoters biorxiv.org 2026-07-08 Transcription factors (TFs) regulate gene expression through sequence-specific DNA binding, and their genomic occupancy is further influenced by TF ex
Mechanistically informed adaptive dosing for cancer immunotherapy using AI-guided decision making biorxiv.org 2026-07-08 Optimizing dose and schedule remains a central challenge in oncology drug development, particularly for immunotherapies where fixed dosing regimens of
Loss of m6A unmasks a senescence-associated inflammatory program in human microglia biorxiv.org 2026-07-08 Chronic microglial inflammation and cellular senescence are hallmarks of the aging brain, yet the molecular events that lock microglia into durable in
NinjaSeq: programmable restriction enzyme-based sequencing library preparation with random access for DNA data storage biorxiv.org 2026-07-08 DNA data storage allows sequences to be defined without biological constraints, yet readout workflows still depend on generic end-repair/dA-tailing ch
A Comparative Study of Plasma Biomarkers of Neurodegeneration in Rhesus Monkeys (Macaca mulatta) and Baboons (Papio anubis) biorxiv.org 2026-07-08 Many nonhuman primate species recapitulate the neuropathological features of sporadic Alzheimer's disease (AD) to varying degrees.
HERO: A hierarchy-aware analysis pipeline for reducing and refining whole-brain atlas-mapped cellular datasets biorxiv.org 2026-07-08 Advances in high-throughput mesoscale microscopy and machine learning-based image analysis pipelines have made unbiased whole-brain imaging widely acc
Basal forebrain projections to the lateral habenula sex-dependently regulate ethanol and sucrose consumption biorxiv.org 2026-07-08 Background: Compulsive alcohol use despite negative outcomes is a defining characteristic of alcohol use disorder.
Coupled Transcriptomic and ECM-Mechanical Remodeling Reveal Mechanotransductive Pathways in Spinal Cord Injury biorxiv.org 2026-07-08 Spinal cord injury (SCI) leads to the formation of a chronic scar composed of glial and fibrotic components that severely restrict neural regeneration
Interpretable and scalable spatial gene set activity analysis with GESSO uncovers functional tissue architecture biorxiv.org 2026-07-08 Recent advances in spatially resolved transcriptomics (SRT) enabled measurement of sets of pathway genes activity within tissues.
Aging restricts colorectal tumor growth by epigenetically silencing developmental gene programs biorxiv.org 2026-07-08 The incidence of early-onset colorectal cancer (CRC) has risen sharply in recent decades1, yet the biological basis underlying the distinct behavior o
DSPE-PEG does not retain targeting antibodies on LNP surfaces in vivo; a higher molecular weight anchor is required biorxiv.org 2026-07-08 Extrahepatic delivery of lipid nanoparticles (LNPs) to non-phagocytic cells is a major challenge, with the leading strategy involving surface function
Kidney medulla macrophages maintain a free flow of urine by sensing force biorxiv.org 2026-07-08 Blockade by sedimentary particles, such as mineral crystals, is a continuous risk the kidney tubule faces.
The SEA-AD DREAM Challenge: Community benchmarking human and AI agent solutions for Alzheimer's disease neuropathology prediction from single-nucleus transcriptomics biorxiv.org 2026-07-08 Single-nucleus transcriptomic atlases offer an unprecedented opportunity to connect cellular molecular states with Alzheimer's disease (AD) neuropatho
Mating imperatives drive plasticity of the daily temporal niche via dopamine signaling. biorxiv.org 2026-07-08 Temporal niche partitioning is a strategy for reducing interspecies competition and strengthening reproductive isolation.
Potential Role of Nociceptin/Orphanin FQ in the Progression of Multiple Sclerosis biorxiv.org 2026-07-08 We showed before that the endogenous peptide Nociceptin blocks the premature differentiation of oligodendrocytes (OLGs), preventing untimely precociou
The Attentional Thief: How Self-Paced Visual Exploration Compresses Subjective Time biorxiv.org 2026-07-08 Social media users often feel that time vanishes while scrolling, but real feeds confound novelty, rewards, social signals, and self-paced control, le
Lamin A/C regulates the compartment-specific contributions of immune and stromal cells to intestinal inflammation and colitis-associated colon cancer biorxiv.org 2026-07-08 Inflammatory bowel disease (IBD) arises from dysregulated crosstalk between innate immune, adaptive immune, and stromal compartments, yet the compartm
A large-scale analysis of the R2TP chaperone network reveals its contribution to the assembly of INO80, SRCAP and TIP60 biorxiv.org 2026-07-08 HSP90/R2TP is an essential quaternary chaperone composed of RPAP3, PIH1D1 and the RUVBL1/RUVBL2 AAA+ ATPases.