K63-linked ubiquitin chains mark inactive Smoothened for packaging into ciliary extracellular vesicles biorxiv.org 2026-07-09 Signaling receptors can exit cilia either by retrieval back into the cell or by secretion in extracellular vesicles (EVs), a process known as ectocyto
Transient architecture of the embryonic pancreas determines endocrine mass biorxiv.org 2026-07-09 During organogenesis, epithelial tissues undergo extensive three-dimensional (3D) remodeling while simultaneously generating specialized cell types.
Guide-tree bias of whole genome alignment can mislead phylogenomic analyses biorxiv.org 2026-07-09 Whole-genome alignment (WGA) is widely used for genome-scale phylogenetic inference, and most scalable WGA pipelines rely on progressive alignment gui
Metabolic Rewiring in Triple-Negative Breast Cancer: Systems Analysis of TCGA-BRCA Transcriptome Reveals Prognostic Hub Genes biorxiv.org 2026-07-09 Triple Negative Breast Cancer (TNBC) is the deadliest and most aggressive subtype of breast cancer, with poor prognosis and high rates of metastasis.
Transcriptionally defined AML cell states associate with treatment response and microenvironmental remodeling biorxiv.org 2026-07-09 While therapy resistance in acute myeloid leukemia (AML) is often attributed to leukemic stem cells (LSCs), their functional properties are not fully
Head-to-head organized segmental paralogs AtOFP2 and AtOFP17 exhibit differential, spatio-temporal partitioning of function, and negative regulation of multiple developmental traits including seed-yield and root architecture biorxiv.org 2026-07-09 Ovate Family Proteins (OFPs) are a class of plant-specific, negative nuclear transcriptional regulators characterized by conserved C-terminal OVATE do
Novel quantitative trait loci conferring broad-based resistance to root-knot nematodes in lima bean (Phaseolus lunatus) biorxiv.org 2026-07-09 Lima bean (Phaseolus lunatus) is a broadly adapted, economically important leguminous crop and a susceptible host of root-knot nematodes (Meloidogyne
The MicroTron: a microfluidic platform for single cell studies in P. patens biorxiv.org 2026-07-09 O_LIThe effect of some bioactive compounds on living organisms is dependent on their concentration and gradients, as is the case of hormones and signa
Photoswitchable optoGPCRs for reversible control of Gs and arrestin signalling biorxiv.org 2026-07-09 OptoGPCRs are light-activatable G protein-coupled receptors (GPCRs) used for optogenetic control of physiological processes.
Regulation of RNA maturation by the family of human G-patch proteins biorxiv.org 2026-07-09 The family of human G-patch proteins comprises more than 20 members, each characterized by a glycine-rich G-patch implicated in mediating interactions
A Cross-Species Systems Genetics Framework Identifies Causal Genes in Diabetic Nephropathy biorxiv.org 2026-07-09 Diabetic nephropathy (DN) is the leading cause of kidney failure in the developed world, but the genetic architecture of DN susceptibility is not well
Biological Network Organization, Not Generic Graph Topology, Drives Graph-Based Gene Essentiality Prediction biorxiv.org 2026-07-09 Predicting gene essentiality across cellular contexts is a central challenge in computational biology, with implications for identifying cancer vulner
Trisomy 21 Impairs Development of Enteric Neural Crest-Derived Cells via SOD1-Mediated RET Dysregulation biorxiv.org 2026-07-09 Hirschsprung disease (HSCR) is a rare congenital disorder of the enteric nervous system (ENS), marked by the absence of enteric ganglia along variable
Rapid and efficient oligodendrocyte differentiation from human pluripotent stem cells via dual inhibition of BMP and Notch signaling biorxiv.org 2026-07-09 The protracted timing required for oligodendrocyte differentiation from human pluripotent stem cells (hPSCs) has limited their use in disease modeling
Smad1 and Smad5 differentially transduce BMP signaling during in vitro differentiation of mouse embryonic stem cells into dorsal interneurons biorxiv.org 2026-07-09 A central unresolved question in development biology is how systems of overwhelming complexity arise from relatively few families of growth factors.
SMAD4 MH2 Mutations Disrupt CREBBP/EP300 Recruitment and TGF-β-Induced Transcription in Colorectal Cancer biorxiv.org 2026-07-09 SMAD4 is a central transcriptional effector of the TGF-{beta} signaling pathway and a frequently inactivated tumor suppressor gene in various cancers.
NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation biorxiv.org 2026-07-09 Aberrant epigenetic reprogramming together with dysregulated mTOR signaling are hallmarks of cancer, where altered chromatin methylation and nutrient-
Linker-Length Landscape Mapping Enables Coupling of Diverse Synthetic Chemically Induced Dimerization Systems to Molecular Readouts biorxiv.org 2026-07-09 Programmable molecular biology increasingly requires strategies for converting engineered recognition or proximity modules into measurable outputs, pa
Shield-4i: A Whole-mount Multiplexed Imaging Platform for Studying Multiscale Information Flow in 3D Multicellular Systems biorxiv.org 2026-07-09 Self-organization in multicellular systems emerges from reciprocal interactions across spatiotemporal scales.
Liver microbiome composition associates with histological severity and PNPLA3 genotype in metabolic dysfunction-associated steatotic liver disease biorxiv.org 2026-07-09 BACKGROUNDMetabolic dysfunction-associated steatotic liver disease (MASLD) is a systemic immunometabolic disorder rapidly increasing worldwide, affect
GIGYF2/4EHP-Mediated Translational Attenuation Maintains Cellular Homeostasis Following Ionizing Radiation biorxiv.org 2026-07-09 Translational regulation is a critical component of the cellular response to environmental stress.
Dfm1 promotes Ste24-dependent translocon quality control biorxiv.org 2026-07-09 Proteins stalled during endoplasmic reticulum translocation clog Sec61 channels and require translocon quality control (TQC) mechanisms for clearance.
Bacterial Hsp70 DnaK transiently samples the proteome to rapidly capture stress-induced misfolding biorxiv.org 2026-07-09 Protein-quality-control systems are essential for cells to maintain protein homeostasis during both steady-state growth and acute stress.
Late embryonic expansion of a novel bone ridge underlies the evolutionary transformation of cylindrically shaped forelimb bones into the flattened skeleton of the penguin flipper biorxiv.org 2026-07-09 The evolution of flippers for wing-powered diving in penguins is a striking example of tetrapod limb specialization.
Subfunctionalization of tbx2 paralogues during photoreceptor cell specification in zebrafish biorxiv.org 2026-07-09 Zebrafish possess three distinct sources of retinal progenitors that produce identical photoreceptor subtypes throughout life.
Cytogenomic signatures of hybridisation in the genus Carpobrotus reveal biased parental dominance biorxiv.org 2026-07-09 O_LIHybridisation is frequently associated with plant invasions; however, its consequences for genome organisation and chromosome evolution remain poo
Selective autophagy promotes bacterial immunity under warming through NBR1-dependent regulation of ABI5 biorxiv.org 2026-07-09 Elevated temperatures compromise plant immunity and increase susceptibility to bacterial pathogens through extensive reprogramming of hormone signalin
A Chemically Defined Synthetic Cell Capable Of Growth And Replication biorxiv.org 2026-07-09 Cells are the fundamental unit of life. Yet there is no natural cell for which all its life-essential functions are understood.
Dissecting human fetal cardiac repair using cardioids biorxiv.org 2026-07-09 Human cardiac injury responses are governed by dynamic interacting processes that are difficult to resolve.
Thematic Shifts in Early-High-Impact Cancer Genomics and Diagnostics Research: A Bibliometric and Semantic Analysis biorxiv.org 2026-07-09 Cancer genomics and diagnostics is a rapidly evolving field in which identifying which topics attract early citation prominence can inform laboratory