Simulations show increased lipid interdigitation in transmembrane coupling of protein condensates biorxiv.org 2026-07-10 Liquid-liquid phase separation of proteins has been observed to occur on biological membranes, where it is thought to play a role in diverse cellular
A single chromosome 3p break initiates clear cell renal cell carcinoma evolution biorxiv.org 2026-07-10 Clear cell renal cell carcinoma (ccRCC) is initiated by chromosome 3p loss, yet chromosome losses impose a profound fitness burden on normal cells.
Hormone-dependent receptor docking controls calcium channel activity in plants biorxiv.org 2026-07-10 The phytohormone auxin is a central coordinator of plant growth and development.
Interspecific transfer of specialized metabolites in root exudates coincides with root chromatin regulation and systemic chemical defenses in rice biorxiv.org 2026-07-10 Benzoxazinoids are a paradigmatic class of indole-derived specialized metabolites released into the soil through root exudates and originally studied
Quantification of cardiac-locked brainstem velocity at high resolution based on retrospectively-gated DENSE MRI at 7T biorxiv.org 2026-07-10 Purpose: The motion of the brain tissue within the skull is thought to be induced by cardiac pulsations and other hemodynamic processes and may influe
Voluntary oral fentanyl intake produces dose- and sex-dependent physical dependence in mice without overt affective disturbances biorxiv.org 2026-07-10 The ongoing opioid epidemic underscores the need for scalable and translational preclinical models of voluntary opioid intake and dependence.
N-Methyl-D-Aspartate receptors control in vivo striatal calcium and the updating of action policy biorxiv.org 2026-07-10 Animals must execute learned behaviors and update them when outcomes change, yet the neural substrates controlling this phenomenon are not fully under
The RLR-MAVS-IRF3 axis activates the IFN pathway to restrict Tonate virus (TONV) infection biorxiv.org 2026-07-10 Tonate virus (TONV) is a neglected mosquito-borne alphavirus of the Venezuelan equine encephalitis complex associated with febrile illness, encephalit
Molecular-level analysis of serum IgG repertoires in COVID-19-vaccinated people with cystic fibrosis identifies abundant convergent antibodies biorxiv.org 2026-07-10 Background: People with cystic fibrosis (pwCF) are at increased risk of severe disease following respiratory viral infections including influenza and
A Variant-Resistant Linear Epitope in the SARS-CoV-2 Nucleocapsid Protein for Antigen Detection biorxiv.org 2026-07-10 We previously generated a mouse monoclonal antibody, N179, against the SARS-CoV-2 nucleocapsid (N) protein and developed a colloidal gold-based immuno
Strong leaders promote cooperation in heterogeneous populations biorxiv.org 2026-07-10 Many proposed mechanisms for the evolution of cooperation among unrelated individuals rely on relatively demanding cognitive abilities that are not wi
Application of the Bradley-Terry model to quantify components of sperm competition biorxiv.org 2026-07-10 In many species with female sperm storage, ejaculates from multiple males overlap in the female reproductive tract, making sperm competitive ability a
MKMC enables reference-free transcriptomic analysis using k-mer representations biorxiv.org 2026-07-10 Traditional RNA-seq analysis depends heavily on genome alignment and gene annotation, limiting its utility in non-model organisms and introducing bias
The evolution of a condition-dependent mutation rate enhances evolvability biorxiv.org 2026-07-10 Empirical studies have demonstrated that mutation rates may change with individual condition, such as in the case of stress-induced mutagenesis.
No evidence that polyploids arise during periods of environmental upheaval. A reply to Chen et al. (2026) biorxiv.org 2026-07-10 Ancient whole-genome duplications (WGDs) are thought to have played a major role in plant evolution, but robust inference of the patterns and drivers
Shifts in Genetic Diversity of Porcine Reproductive and Respiratory Syndrome Virus 2 in Vietnam Before and After African Swine Fever: Increased Diversity and Novel Sub-lineages biorxiv.org 2026-07-10 Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) remains one of the most important transboundary pathogens affecting swine production i
Synthetic iminosugar monomers change global metabolic pathways and chitin biosynthesis in Thalassiosira rotula biorxiv.org 2026-07-10 - Thalassiosira rotula produces extracellular chitin fibers of interest for material science.
Diversity Assessment with SNP, SSR, AFLP, and RAPD Markers in Plants: A Systematic Review and Meta-Analysis biorxiv.org 2026-07-10 BackgroundDNA-based molecular markers underpin plant genetic diversity assessment, germplasm characterisation, and conservation prioritisation.
AgroGem: A Rapid and Scalable Transient Transformation System for Functional Genetics in Multiple Plant Species biorxiv.org 2026-07-10 Plant genetic transformation technologies are essential for functional genomics and genome engineering in plants.
An integrative single-cell and spatial transcriptomics atlas highlights candidate regulatory factors in the development of gerbera capitulum biorxiv.org 2026-07-10 In Asteraceae species, the capitulum is a compact inflorescence, featuring a characteristic reproductive structure.
Extracellular injection system combined with peptides for intracellular Staphylococcus aureus treatment biorxiv.org 2026-07-10 The inaccessibility of intracellular bacteria has long rendered the treatment of Staphylococcus aureus infections an challenge.
BxbI-mediated insertion of a 77kb human RET sensitive haplotype into the mouse genome to generate a humanized model of Hirschsprung disease biorxiv.org 2026-07-10 Hirschsprung disease (HSCR) is a complex developmental disorder of the enteric nervous system, primarily driven by regulatory variants within enhancer
HetNetEX: Exact Asymptotic Inference in Heterogeneous Biomedical Knowledge Graphs biorxiv.org 2026-07-10 Heterogeneous biomedical knowledge networks (hetnets) integrate disparate data types, drugs, genes, diseases, and pathways, across independent sources
Metabolomic signatures support the diagnostics of peritoneal endometriosis using generalised linear models biorxiv.org 2026-07-10 Endometriosis, a common inflammatory gynecological disorder affecting up to 10% of women worldwide, is characterized by the presence of endometrium-li
Central and peripheral dynamics of acute stress: evidence from functional cortical gradients biorxiv.org 2026-07-10 Stress involves coordinated central and peripheral processes that unfold dynamically and can be assessed through brain, autonomic, endocrine, and subj
Sleep-Related Respiratory Disruption is Associated with Altered Spindle Morphology and Poorer Attention in Children biorxiv.org 2026-07-10 Study Objectives.
Humans integrate gaze and decision cues for inferring preferences in social interactions biorxiv.org 2026-07-10 Social decision-making depends on inferring others' hidden preferences from observable behavior.
OLD sentinel: an abortive tRNase surveys phage replication and DNA defects in RecBCD-compromised cells biorxiv.org 2026-07-10 OLD, an abortive immunity protein from prophage P2, consists of an ABC ATPase sensor and a TO-PRIM nuclease effector - a core architecture shared by a
Circulating extracellular vesicles in plasma carry accessible molecular signatures of aging in mice biorxiv.org 2026-07-10 Cells release membrane-bound extracellular vesicles into the bloodstream laden with proteins that may reflect their physiological state.
Targeting Autophagy Accelerates Intestinal Repair after Acute Ionizing Radiation biorxiv.org 2026-07-10 Radiation exposure induces systemic and cellular damage, contributing to acute radiation syndrome and long-term effects such as premature aging and ca