Locus-Level Transposable Element Profiling Resolves Division-Coupled Transcriptional Dynamics During Human Endoderm Specification biorxiv.org 2026-07-11 Background: Transposable elements (TEs) constitute nearly half of the human genome and are now recognized as significant contributors to mammalian gen
Multiscale harmonization and semantic integration of biomedical data enable biological insights through immersive exploration biorxiv.org 2026-07-11 The Human Reference Atlas (HRA) enables multiscale data exploration and visualization.
Single-cell RNA-seq reveals conserved and divergent cellular states across wound types and species biorxiv.org 2026-07-11 Chronic wounds, such as diabetic foot ulcers, fail to progress through the normal healing process and impose a significant burden on healthcare system
Benchmarking AI Protein Structure Predictors Reveals a Persistent Bias in Multi-State Proteins biorxiv.org 2026-07-11 Protein structure predictors achieve high single-state accuracy, but it remains unclear whether they can recover functionally relevant conformational
RNA and proteins joined up at the Origins of Life: Persistence is the point biorxiv.org 2026-07-11 What drove nucleic acids (NA) to associate with proteins (PR) at the Origins of Life?
Bioelectrical phase transitions biorxiv.org 2026-07-11 Electrical signaling in biological systems is generally understood through the lens of single-channel biophysics, yet whether ensembles of ion channel
Mycobacterium tuberculosis Δlsr2 Vaccine Enhances Protection Against Tuberculosis biorxiv.org 2026-07-11 Tuberculosis (TB) has been a leading cause of death from a single infectious agent for decades.
Root rot by Phytophthora cinnamomi shifts the composition and structure of avocado rhizosphere fungal communities biorxiv.org 2026-07-11 Rhizosphere microbial communities contribute to the growth and health of their host but may be altered by the incidence of soil-borne pathogens.
Macro evolutionary patterns do not predict micro evolutionary trajectories biorxiv.org 2026-07-11 As the world's oceans change in response to climate change, phytoplankton communities will adapt to warmer, more stratified surface waters via plastic
Temporal Development of the Tracheal Microbiome Across Production Phases in Broiler Chickens biorxiv.org 2026-07-11 The respiratory microbiome plays important roles in poultry health, immune regulation, and pathogen resistance, yet its development throughout the bro
Cultivation of halophilic archaea in shallow subsurface martian conditions has implications for extant life on Mars biorxiv.org 2026-07-11 The present-day martian surface is generally considered inhospitable to life because of low atmospheric pressure, intense surface radiation, global de
Lytic bacteriophages against Salmonella Typhi as a potential alternative to antibiotics biorxiv.org 2026-07-11 Introduction: Enteric fever, being endemic with seasonal peaks in low- and middle-income countries, is a major health concern.
Ruminococcus hollandia sp. nov. and Ruminococcus vasco sp. nov., two novel starch-degrading Ruminococcus isolated from the rumen of Holstein dairy cattle biorxiv.org 2026-07-11 This study investigated the genomic and biochemical characteristics of two amylolytic microbial strains, NATIVEDY160T (=NRRL B-68523) and NATIVEDY161T
SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions biorxiv.org 2026-07-11 Single-cell transcriptomics has enabled systematic profiling of cellular states across ordered biological contexts, including developmental stages, tr
Limitations of EBV transformed human Raji B cells as a model for measuring canonical NF-κB activation biorxiv.org 2026-07-11 Autoimmune diseases, such as systemic lupus erythematosus (SLE), are underscored by dysregulated B cell function including the production of autoantib
A genetically buffered helicase network promotes tolerance of G-quadruplex stabilization in Saccharomyces cerevisiae biorxiv.org 2026-07-11 G-quadruplexes (G4s) are non-canonical DNA secondary structures that can impede DNA replication and transcription and provoke genome instability, and
Placental invasion mismatch underlines pregnancy disorders and cancers biorxiv.org 2026-07-11 Mammalian placentas vary dramatically in invasiveness, parallel aggressive cancers, and are dysregulated in pregnancy disorders, yet whether they shar
Gene model for the ortholog of raptor in Drosophila grimshawi biorxiv.org 2026-07-11 Gene model for the ortholog of raptor in the D.
Metagenomic contextualization of proteins with state space models biorxiv.org 2026-07-11 Since the early adoption of metagenomics (the culture-free sequencing of microbial community genomes) in 2011, sequence data has increased over 500-fo
Assessment of sensorimotor cortical beta oscillations from peripheral electromyography and force recordings biorxiv.org 2026-07-11 The beta oscillations of the human primary sensorimotor cortex (SM1) play a crucial role in regulating motor and cognitive behavior in health and dise
Optimizing MR-based gaze-decoding for eyes-closed eye-tracking in fMRI biorxiv.org 2026-07-11 Eye movements provide valuable insights into human cognition and are a critical variable in numerous functional magnetic resonance imaging (fMRI) stud
Simple Geometric Recentering Rivals Deep Sequence Models for Cross-Session EEG Motor-Imagery Decoding biorxiv.org 2026-07-11 A large and growing body of work applies increasingly complex deep architectures to EEG motor-imagery (MI) decoding, yet rarely tests whether that com
E-cadherin maintains oral Langerhans cell barrier surveillance to preserve microbiota-dependent immune homeostasis biorxiv.org 2026-07-11 Langerhans cells (LC) are specialized antigen-presenting cells that form a dense immune surveillance network within the oral epithelium.
A transcriptional continuum links viral burden and host-cell biology in human lymphoid tissue biorxiv.org 2026-07-11 Human immunodeficiency virus (HIV-1) persistence in lymphoid tissue remains a major barrier to cure, yet infected cells are commonly represented using
Tricuspid valve regurgitation accelerates heart failure via a cardio-intestinal innate immune circuit biorxiv.org 2026-07-11 Activation of the immune system impacts the progression of heart failure (HF), but the underlying mechanisms remain incompletely understood.
Northward expansion of Rugulopteryx okamurae (Dictyotales, Ochrophyta) in the southeastern Iberian Peninsula: first record in Calpe (Comunitat Valenciana) biorxiv.org 2026-07-11 The non-indigenous brown macroalga Rugulopteryx okamurae has emerged as one of the most aggressive marine invaders in European waters, deeply altering
A Novel Operant Conditioning Task to Assess Motivation to Exercise in Rats biorxiv.org 2026-07-11 Voluntary physical activity is a highly motivated behavior with important implications for physical and mental health, yet the neural and endocrine me
Somatic mutation inference from single-cell transcriptomics: A survey in the esophagus biorxiv.org 2026-07-11 Human somatic tissues accumulate mutations during normal aging.
AGPI: An AI-Powered Genomic Pathogen Intelligence Platform for Integrated Classification, Visualization, and Therapeutic Targeting biorxiv.org 2026-07-11 Rapid and accurate pathogen detection remains a major challenge in modern bioinformatics, as existing tools are often fragmented and require multiple
Dynamics of ML-based Morphological Features Indicate a Shear Stress-Dependent Bifurcation of hiPSC-Derived Endothelial Cell States biorxiv.org 2026-07-11 Cell states are increasingly conceptualized as attractors of high-dimensional dynamical systems, yet quantitative approaches for integrating phenotypi