A Bioengineered Live Biotherapeutic Exploits Inflammation to Restore Gut Liver Brain Axis Function under Diet-Induced Stress biorxiv.org 2026-07-13 Live biotherapeutic products (LBPs) show promise for treating metabolic and inflammatory diseases, but their efficacy is limited by poor persistence i
Structural modeling uncovers diverse predicted transcriptional and post-transcriptional modulators among type III effectors of symbiotic Rhizobia biorxiv.org 2026-07-13 Rhizobia are soil bacteria that establish nitrogen-fixing symbioses with legumes.
Adeno-Associated Virus (AAV) Synthetic Inverted Terminal Repeats Enhance Tissue-Specific Transduction and Alter the Vector Induced Stress Response biorxiv.org 2026-07-13 While adeno-associated virus (AAV) vectors have shown therapeutic benefit in clinical applications, noted challenges include low transduction efficien
From background to foreground: secondary antibodies coupled to lipophilic ATTO dyes enable high-density membrane labeling in super-resolution and expansion microscopy biorxiv.org 2026-07-13 Classical immunolabeling approaches can achieve homogeneous and continuous labeling of cellular membranes and organelles at wide-field and confocal re
A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription biorxiv.org 2026-07-13 The Ca2+ release-activated Ca2+ (CRAC) channel mediates store-operated calcium entry (SOCE), a ubiquitous pathway essential for many cell types, inclu
A cargo receptor entrapment complex is a therapeutic node for genetically and clinically distinct proteinopathies biorxiv.org 2026-07-13 Severe proteinopathies, such as retinitis pigmentosa, a form of inherited blindness, are driven by genetic mutations that overwhelm the quality contro
Short term effects of salinization on the plankton community of an oligotrophic mountain lake biorxiv.org 2026-07-13 Freshwater salinization is of increasing concern for integrity and functioning of freshwater habitats worldwide.
An overlooked distal regulatory signal on a shared haplotype drives the neuroinflammatory cascade underlying GBA1-associated Parkinson's disease biorxiv.org 2026-07-13 BACKGROUND The persistent puzzle of how GBA1 coding variants underlying monogenic Gaucher disease confer such strong risk for polygenic Parkinson's di
Capillary Network Generation Framework for Estimating Volumetric Capillary Density from Histological Vascular Measurements biorxiv.org 2026-07-13 Angiogenesis drives the formation and remodeling of capillary networks throughout tissue repair, regulating the vascular environment that supports hea
Myeloid-Specific Pck1 Deficiency Does Not Alter Aortic Root Atherosclerosis in Mice biorxiv.org 2026-07-12 Background: We previously performed a strain intercross between atherosclerosis resistant AKR Apoe-/- mice and atherosclerosis sensitive DBA/2 Apoe-/-
ProtBLIP2-SST: Protein Function Prediction via BLIP2 with Sequence, Structure, and Text biorxiv.org 2026-07-12 Protein function prediction traditionally relies on structured gene ontology (GO) labels or multi-label classifiers.
OCellus: A Language-Model Framework for Single-Cell, Spatial, and Perturbation Biology with Natural-Language Reasoning biorxiv.org 2026-07-12 Computational modeling of cellular behavior - the virtual cell - has emerged as a stated grand challenge at the intersection of artificial intelligenc
Genomic Annotation Infrastructure (GAIn): Pipelines and Resource Repositories for Annotating Variants, Positions, and Regions biorxiv.org 2026-07-12 Interpretation of genomic variants, positions, and regions depends on reliable annotation - adding evidence such as predicted effect, conservation, po
A geometric atlas of how ESM3 organizes modalities across depth biorxiv.org 2026-07-12 Protein language models learn general-purpose representations from large collections of protein sequences and structures, and have advanced the predic
TEscape: Defining the human transposable element transcriptome using multiplatform long-read sequencing biorxiv.org 2026-07-12 Transposable elements (TEs) not only account for half of the human genome sequence but also generate transcripts that contribute to transcriptomic div
EcoMorph: Universal morphological trait quantification from natural language prompts for ecological research biorxiv.org 2026-07-12 1.
Gene Regulatory Networks Mediate Pattern Scaling in Growing Tissues biorxiv.org 2026-07-12 Developmental patterns can scale with size during growth, a phenomenon commonly attributed to morphogen scaling.
A practical framework for measuring protein oligomerization equilibria by fluorescence correlation spectroscopy biorxiv.org 2026-07-12 Protein oligomerization equilibria are central to many biological processes and are often highly sensitive to environmental conditions such as ionic s
Spatial Glyco-Codes Define Human Liver Pathology and Progression biorxiv.org 2026-07-12 Glycosylation is a fundamental process regulating cellular function, tissue organization, and disease progression.
The D2-mdx mouse as a preclinical model for Duchenne muscular dystrophy: a natural history study across two independent sites biorxiv.org 2026-07-12 Introduction.
The Tricuspid Valve Maladapts in a Pulmonary Hypertension Rat Model biorxiv.org 2026-07-12 Tricuspid valve regurgitation is a frequent valve lesion and, if severe, an independent predictor of mortality.
Striatal cholinergic and dopaminergic driven astrocyte Ca2+ activity is disrupted in Parkinsonian mice biorxiv.org 2026-07-12 Brain neuromodulatory systems exert powerful effects on local neuronal circuit function and behavior.
Muscle spatial lipidomics identifies early ALS signatures in presymptomatic SOD1G93A mice biorxiv.org 2026-07-12 Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease whose diagnosis often remains delayed.
Transcriptional Characterization of Nuclear-Integrated Organellar DNA in Populus biorxiv.org 2026-07-12 The continuous transfer of organellar DNA into the nuclear genome during eukaryotic evolution has resulted in the widespread occurrence of nuclear pla
Fertility Gene Introns Harbor Transposable Elements that Shape Y-Loop Architecture biorxiv.org 2026-07-12 Transposable elements (TEs) are powerful drivers of genome evolution, yet how they persist under selection and become incorporated into host regulator
The YTHDC1 glutamate-rich domain docks to the ADAR1 Zα Domain, linking the N6-methyladenosine modification of pre-mRNAs to dsRNA editing biorxiv.org 2026-07-12 The p150 isoform of the double-stranded RNA editing enzyme ADAR1 binds Z-DNA and Z-RNA through the conserved winged helix-turn-helix Z domain.
BioMetAll v2.0: Introducing Scores, Metal Discrimination, and Side-Chain Descriptors for Predicting Metal-Binding Sites in Proteins. biorxiv.org 2026-07-12 Predicting the location of metal-binding sites in proteins is crucial for fundamental biological questions and biotechnological applications.
Structures of the human sodium-citrate cotransporter NaCT with and without substrates biorxiv.org 2026-07-12 The human sodium-citrate cotransporter NaCT imports various tri- and dicarboxylates into the cell as TCA cycle intermediates.
Synovium-Restricted Armored PD-1-Targeted CAR-T Cells Reprogram Immunity and Resolve Experimental Arthritis biorxiv.org 2026-07-12 Despite major therapeutic advances, a substantial fraction of patients with autoimmune disease remains refractory to treatment.
Stress-induced motivational impairment is marked by diminished frontocortical cellular communication and neuropeptide signaling biorxiv.org 2026-07-11 Background Repeated stress is a risk factor for developing motivational deficits which are common across a variety of disease states including depress