Microfluidic Osteoarthritis-on-a-Chip for Evaluating Joint-Cell Responses to Tanezumab, a Humanized Anti-NGF Monoclonal Antibody biorxiv.org 2026-07-14 Osteoarthritis (OA) drug development remains constrained by preclinical models that fail to recapitulate the multicellular interactions that regulate
Photosoftening Macroporous Hydrogels for Dynamic Tissue Engineering biorxiv.org 2026-07-14 With the push towards accessible benchtop models to capture biological events, many researchers are reaching for hydrogel platforms for 3D tissue engi
Temporal decoding of blood flow derived mechanical cues driving liver regeneration biorxiv.org 2026-07-14 Liver regeneration is initiated by rapid vascular changes, yet how blood flow-derived mechanical cues are decoded by liver sinusoidal endothelial cell
Titanium and platinum coatings reduce inflammation induced by gold on subretinal prosthesis biorxiv.org 2026-07-14 Subretinal photovoltaic implants provide central vision to patients blinded by atrophic age-related macular degeneration, with acuity limited by their
The basal cell state maintains pancreatic cancers by controlling an immunosuppressive circuit biorxiv.org 2026-07-14 Intra-tumoral heterogeneity is a cardinal feature of solid tumors, yet how distinct cancer cell states functionally contribute to malignant and stroma
Mitophagy Inhibition Promotes Survival and Mitochondrial Function in MYC-driven HCC biorxiv.org 2026-07-14 Hepatocellular carcinomas (HCC) are genetically heterogeneous cancers frequently characterized by MYC gene amplification or hyperactivating {beta}-cat
Neuronal stop-codon readthrough is associated with ribosome pausing and alters protein localization in Drosophila biorxiv.org 2026-07-14 Stop-codon readthrough (RT) diversifies proteomes and is particularly prominent in neurons, suggesting its importance in nervous systems.
Explainable AI identifies recombination and chromatin environment as key predictors of subgenome evolution in maize and Brassica biorxiv.org 2026-07-14 Polyploidy, or whole genome duplication, reshapes genomes through biased gene loss and regulatory rewiring, yet the drivers of biased fractionation am
Development of an Ethylenediaminetetraacetic Acid-Enhanced Deep Proteomic Profiling Method for Dried Blood Spots and Its Application in Mouse Disease Models biorxiv.org 2026-07-14 Dried blood spots (DBS) are well-established microsamples used in clinical testing and newborn screening.
Drought reshapes enhancer-like nascent transcription and gene regulation in Oryza sativa biorxiv.org 2026-07-14 Drought increasingly constrains global rice productivity, yet how water deficit remodels cis-regulatory activity in plants remains poorly resolved.
Diversity in transcriptomics without cell types biorxiv.org 2026-07-14 Downstream analysis in single-cell and spatial transcriptomics is highly dependent on a sequence of upstream modeling choices.
Kinetochore-microtubule attachments are strengthened by Cnn1 stabilization of Stu2 biorxiv.org 2026-07-14 Accurate chromosome segregation requires kinetochores to form robust, load-bearing attachments to dynamic spindle microtubules, mediated primarily by
Dendritic varicosities revealed as important micro-tubule organisers in neurons biorxiv.org 2026-07-14 Microtubules are polarised polymers that assemble into highly specialised networks in a cell-specific manner.
Disruption of Histone H4C genes impairs skeletal development and cortical neurogenesis, modeling rare neurodevelopmental syndromes biorxiv.org 2026-07-14 Histone proteins, which reside in the nuclei of eukaryotic cells, are involved in diverse cellular processes.
Possible function of Hox2 in atrial siphon fusion of the ascidian Ciona biorxiv.org 2026-07-14 The hallmark of sessile adult ascidians is a vase-like shape with a single oral and atrial siphon.
Ependymomas are cancers of the pre-neural crest/roof plate lineage biorxiv.org 2026-07-14 Distinct molecular variants of the brain cancer ependymoma are distributed along the rostral-caudal extent of the central nervous system (CNS).
Biochemical Indicators of Atlantification and Diapause Strategy in Arctic Copepods Point to a Decrease in Copepod-mediated Carbon Sequestration biorxiv.org 2026-07-14 Arctic ecosystems are critically endangered by rising temperatures and changing hydrography, especially the intrusion of increasingly warm water from
Behavioral metabolic suppression confounds thermal performance estimates and climate vulnerability assessments in a marine ectotherm biorxiv.org 2026-07-14 1.
The activity, divergence, and evolutionary degradation of modern-day homing endonucleases and their reconstructed ancestors biorxiv.org 2026-07-14 Homing endonucleases are selfish genetic elements that drive the mobilization of their own coding sequences, often in concert with surrounding introns
Ocular Safety and Efficacy of AAV-mediated Tyrosinase Gene Augmentation in a Nonhuman Primate Model biorxiv.org 2026-07-14 Oculocutaneous albinism type 1 (OCA1) is an inherited disorder caused by tyrosinase (TYR) gene mutations.
Structural Tuning of HEWL Amyloid Polymorphs Enhances Antibacterial Activity Against Gram-Positive and Gram-Negative Pathogens biorxiv.org 2026-07-14 Amyloid fibrils are traditionally associated with protein misfolding disorders.
Engineering the bacterial cellulose-forming surface as a programmable protein recruitment interface biorxiv.org 2026-07-14 Synthetic biology has advanced microorganisms to be programmed as production hosts, but its application to bacteria that inherently assemble extracell
SparseSeg: Target-Conditioned Discovery Segmentation of Cryo-Volume Electron Microscopy Under Sparse Annotation biorxiv.org 2026-07-14 Cryo-volume electron microscopy (cryo-vEM) enables near-native visualization of cellular ultrastructure, but its broad use is limited by low image con
Lineage recording reveals hijacked hepatic progenitor states as a common origin of HCC and ICC biorxiv.org 2026-07-14 Fatty liver disease predisposes to primary liver cancer, yet the lineage routes and niche mechanisms that select rare tumor-fated hepatocytes remain u
Biocontainment attenuation of mobile DNA host range in a wastewater microbiome biorxiv.org 2026-07-14 Biocontainment systems designed to attenuate the spread of mobile DNA are challenging to evaluate within microbiomes of engineered environments.
An integrated atlas of RNA to protein concordance across human tissues and cell types biorxiv.org 2026-07-14 Differential expression studies, single-cell atlases, and target discovery pipelines measure RNA as a proxy for protein.
A Microfluidic Platform for Spatiotemporal Dissection of Neurodegeneration Across Hierarchical Human Neural Circuits biorxiv.org 2026-07-14 Understanding how neurodegenerative diseases initiate and propagate through neural circuits remains a fundamental challenge in neuroscience.
The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes biorxiv.org 2026-07-14 Prenatal and early postnatal life is a period of rapid brain growth, making the developing brain particularly susceptible to external influences.
The Illumina Stranded mRNA protocol is not strongly stranded for mRNA with low U content biorxiv.org 2026-07-13 The Illumina TruSeq Stranded and Illumina Stranded mRNA protocols are commonly used for strand-specific bulk RNA-seq and they typically yield >99%
Structural basis of biofilm formation mediated by the Pseudomonas aeruginosa fibrillar adhesin CdrA biorxiv.org 2026-07-13 Many bacteria, including the important human pathogen Pseudomonas aeruginosa, are naturally found in antibiotic-tolerant, multicellular biofilms.