Speed Synchrony Promotes Collective Motion in Mixed-Species Fish Schools biorxiv.org 2026-07-14 Principles of collective motion are now well established, though research has largely focused on homogeneous groups.
miR319-targeted LsTCP4 and non-target LsTCP17 act in parallel to promote leaf senescence in lettuce biorxiv.org 2026-07-14 Leaf senescence directly affects lettuce quality and postharvest shelf life, but the regulatory roles of miR319-targeted and non-target CIN-TCP transc
Laterality of subcortical structures predicts spontaneous brain dynamics biorxiv.org 2026-07-15 Subcortical structures play a key role in shaping cortical computation through distributed cortico-subcortical networks, yet it remains unclear whethe
Decoding and Characterizing the Intracranial Representation of Semantic Information biorxiv.org 2026-07-15 Brain-computer interfaces (BCIs) have achieved impressive performance by decoding motor and articulatory signals associated with speech production.
Molecular dynamics simulations demonstrate reduced antibiotic affinity to mirror bacterial targets biorxiv.org 2026-07-15 Mirror life, self-replicating organisms composed of non-natural-chirality biomacromolecules, presents a future threat with potentially global conseque
SF3B3 / SF3B5 form a metazoan specific transcription module of the U2 snRNP that coordinates Pol II elongation in a splicing independent manner biorxiv.org 2026-07-15 Co-transcriptional splicing is a conserved feature of eukaryotic gene expression.
Beyond climatic drought indices : an hydraulic approach to quantifying forest water stress biorxiv.org 2026-07-15 The article introduces a new Forest Stress Index (ISF) based on a plant hydraulic modelling approach rather than classical climatic drought indices.
The UPRMT is a critical mediator of nutrient immunity biorxiv.org 2026-07-14 Mitochondria serve as critical signaling hubs that monitor the intracellular environment to orchestrate cellular stress responses during pathogen infe
The paraspeckle protein NONO potentiates the antiviral innate immune response through chromatin regulation biorxiv.org 2026-07-14 Type-I interferons (IFN-I) and IFN-stimulated genes (ISGs) are central to antiviral defense, while dysregulation can drive autoimmunity.
Intermolecular disulfide bond formation promotes Hsp42 higher-order assembly and shapes client selection in yeast biorxiv.org 2026-07-14 Cellular redox homeostasis plays a critical role in regulating protein function, including chaperone activity, through reversible oxidation of cystein
Forest degradation reshapes trophic functioning in vertebrate food webs across Amazonian forests biorxiv.org 2026-07-14 The Amazon is a mosaic of ecosystems, accounting for 13% of all known species globally, and responsible for providing a variety of ecosystem services,
Synonymous codon usage is biased for and against m⁶A RRACH motifs in mammals biorxiv.org 2026-07-14 RNA methylation at N-adenosine (mA) predominantly occurs within RRACH motifs, yet the forces shaping these motifs in coding regions remain unclear.
BBB-Nuke: Transport-Aware Prediction of Blood-Brain Barrier Penetration in Small Molecules biorxiv.org 2026-07-14 Predicting blood-brain barrier (BBB) penetration remains a central challenge in CNS drug discovery.
Characterization of Fetal Cortical Development Using Spectral Analysis of Gyrification (SPANGY) biorxiv.org 2026-07-14 The prenatal period of human brain development is critical for mental health and cognition across the entire lifespan.
Single-cell transcriptomic atlas of frontoinsular cortex reveals molecular correlates of selective neuronal vulnerability in FTD biorxiv.org 2026-07-14 Frontotemporal dementia (FTD) is characterized by selective neuronal vulnerability, yet the features that predispose specific neuron types to degenera
PV interneuron-targeted CRISPRa rescue of SCN1A haploinsufficiency in Dravet syndrome biorxiv.org 2026-07-14 Dravet syndrome is a severe epileptic encephalopathy caused by SCN1A haploinsufficiency, which leads to reduced NaV1.1 expression in parvalbumin (PV)-
A canine brain bank for comparative neuroscience and brain aging research biorxiv.org 2026-07-14 Companion animal brain banking has been recognized as a valuable approach for translational aging and dementia research.
Frontolimbic Functional Connectivity Development from Birth to Emerging Adulthood biorxiv.org 2026-07-14 Frontolimbic circuits connecting the frontal cortex with the amygdala and the hippocampus are critical for emotion and learning.
Processing at Phrase Boundaries During Self-Paced Reading biorxiv.org 2026-07-14 Sentence comprehension requires the incremental construction of syntactic structure and semantic interpretation.
Speech clarity shapes auditory attention and visual-signal coupling during multimodal sentence comprehension biorxiv.org 2026-07-14 Face-to-face communication requires listeners to attend, integrate, and weigh multiple communicative signals, including auditory speech, mouth movemen
Mapping the neural circuitry of cognitive restructuring in depressive and anxiety disorders biorxiv.org 2026-07-14 Background: Cognitive restructuring, the process of identifying and challenging negative thoughts, is a key technique for treating depressive and anxi
Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors biorxiv.org 2026-07-14 Comparative transcriptomic studies of neural progenitors implicated in human brain expansion have identified extensive baseline gene expression diverg
PLCγ2 deficiency compromises systemic immune tolerance and erodes myelin homeostasis while enhancing oxidative metabolism in the mouse brain biorxiv.org 2026-07-14 Background: Phospholipase C gamma-2 (PLCg2) catalyzes the hydrolysis of the membrane phosphatidylinositol-4,5-bisphosphate (PIP2) to form diacylglycer
Large-scale automated detection reveals pervasive sex imbalance in biomedical research biorxiv.org 2026-07-14 Sex is a critical biological variable that impacts disease risk, progression, and treatment response across virtually every organ system.
Biophysical Characterization of ParBS Condensates suggests a physical mechanism for segregation biorxiv.org 2026-07-14 The ParABS system orchestrates chromosome segregation in many bacterial species.
Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer's disease lipid-processing microglia biorxiv.org 2026-07-14 Lipid-processing microglia are among the microglial states most strongly associated with Alzheimer's disease (AD) pathology, yet whether this associat
The unique value of zero prediction errors in reinforcement learning biorxiv.org 2026-07-14 Learning is typically understood as a process driven by prediction errors, when outcomes differ from expectations.
α-Synuclein pathology differentially alters T-type calcium currents in vulnerable and resilient substantia nigra dopaminergic subpopulations. biorxiv.org 2026-07-14 Aggregation of -synuclein protein is a characteristic of Parkinson's disease pathology that relates to the degeneration of vulnerable dopaminergic neu
Histone modification crosstalk between host and pathogen biorxiv.org 2026-07-14 Bacterial pathogens modulate host cell physiology by secreting effector proteins that rewire host signaling pathways.
Rt3DE-based finite element analysis of functional tricuspid regurgitation and RV free wall approximation biorxiv.org 2026-07-14 Purpose: Functional tricuspid regurgitation (FTR) is driven by right ventricular (RV) remodeling, annular dilation, and papillary muscle dislocation.