TOPAS: phosphoproteome data analysis and decision support platform for molecular tumor boards biorxiv.org 2026-07-13 The molecular tumor board (MTB) is central to precision oncology, providing personalized treatment recommendations based on molecular profiles of pati
EcoXAI: Autonomous Agentic Ecosystem for Explainable Artificial Intelligence and Biomedical Discovery biorxiv.org 2026-07-13 Motivation: As biomedical datasets and knowledge graphs continue to grow in size, complexity, and heterogeneity, navigating and extracting actionable
Charge Imbalance Drives Salt-Optimized Nucleosome Phase Separation under Physiological Conditions biorxiv.org 2026-07-13 Liquid-liquid phase separation (LLPS) of chromatin contributes to genome organization and regulates genome accessibility to control gene expression.
Supplementation via DAF-16 and pnk-1 driven pantothenate-coenzyme A flux improves disease related stress resistance in C. elegans biorxiv.org 2026-07-13 Metabolic pathways are increasingly recognized as tractable targets in aging and disease.
Assessing Microcirculation Impairment in Ischemic Stroke Mice Using Arteriovenous Co-fluctuation Analysis biorxiv.org 2026-07-13 Accurate assessment of cerebral hemodynamics impairment traditionally relies on arterial metrics, yet often overlooks venous drainage and arteriovenou
Single-nuclear RNA sequencing reveals an ATF3-independent sensory-neuron program after surgical incision biorxiv.org 2026-07-13 Background.
Longitudinal Subject Pairing in Cross-Sectional Neonatal Data Reveals Asynchronous Structural and Functional Brain Maturation biorxiv.org 2026-07-13 The asynchronous development of structural and functional brain networks in early childhood remains largely unexamined, primarily due to the scarcity
Gas-vacuolate Microcystis evolves cyanophage resistance under low nitrogen conditions biorxiv.org 2026-07-13 Cyanophages can influence the dynamics of toxic cyanobacterial blooms.
A Two-Arm Metabolic-Efflux Adaptation Framework in Klebsiella pneumoniae under Mixed Pharmaceutical Exposure: rutA-Linked Oxidative Entry and rutR-Associated Regulation biorxiv.org 2026-07-13 Chemically complex pharmaceutical mixtures in wastewater and sludge can affect microbial adaptation; however, the responses to different co-occurring
Multi-omics integration identifies a reproducible inflammatory host-response axis in pediatric sepsis biorxiv.org 2026-07-13 Sepsis is a major cause of morbidity and mortality in children, yet biological heterogeneity in host responses has limited progress toward targeted th
Adaptive landscape of the metallo-β-lactamase NDM to emerging β-lactam-based therapies biorxiv.org 2026-07-13 The New Delhi metallo-{beta}-lactamase (NDM) is a major determinant of carbapenem resistance.
Robust Myocardial Regeneration After Selective Cardiomyocyte Loss Is Driven by Cardiac Stem Cell Activation Through the miR-221-p57 Axis biorxiv.org 2026-07-13 A central unresolved and highly contested question in cardiac biology is whether the adult mammalian heart, believed to have a very limited endogenous
Structure-guided design of a CD81-binding mini-protein that blocks hepatitis C virus entry biorxiv.org 2026-07-13 Despite the success of direct-acting antivirals, preventing hepatitis C virus (HCV) reinfection remains a critical global challenge.
Language Model Embedding Classifiers Enable Identification of Multiple Sclerosis-Associated BCRs and Repertoires biorxiv.org 2026-07-13 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease.
Biomarker Variability Limits Individualized Amyloid Time Estimation in Alzheimer Disease biorxiv.org 2026-07-13 Objective: Disease progression modeling (DPM) or "amyloid time" is increasingly used to stage Alzheimer disease (AD).
Spliceosome loss in the red tide ciliate Mesodinium rubrum presents a symbiotic cul-de-sac biorxiv.org 2026-07-13 Mesodinium rubrum, a marine microbial eukaryote associated with some of the largest red tides on Earth, has the remarkable ability to commandeer the p
Associative Visual Memory in Aphantasia: Evidence for Intact Object and Spatial Memory, Metacognitive Awareness, but Different Strategies biorxiv.org 2026-07-13 Many forms of memory are thought to rely on visual imagery, but individuals who report lacking visual imagery (aphantasia) can still perform various m
Diffusion Latent Representations for Neural Decoding biorxiv.org 2026-07-13 Neural decoding can be viewed as a representation learning problem in which neural activity is mapped into an intermediate representation before downs
White-Matter BOLD Encoding Beyond Marginal Connectivity biorxiv.org 2026-07-13 Functional MRI studies have traditionally focused on gray matter, whereas white-matter BOLD signals have often been treated as weak or artifactual.
Can we trust subthalamic local field potential? Geometrical and dynamical factors constraining the interpretability of extracellular recordings biorxiv.org 2026-07-13 Local field potentials (LFPs) are widely interpreted as readouts of population synaptic activity, an assumption derived almost entirely from cortical
Tau Isoform Expression Drives Disease Outcomes Following a Single Closed Head Injury biorxiv.org 2026-07-13 Tau protein has been implicated as an important mediator of traumatic brain injury (TBI).
IL-21-producing peripheral helper T cells associate with autoimmune bile duct injury in biliary atresia biorxiv.org 2026-07-13 Abstract Background: Biliary atresia (BA) is a severe neonatal liver disease characterized by progressive fibrosis and bile duct obliteration.
Endophytic colonization pathways of Pseudomonas chlororaphis M71 and Trichoderma atroviride SC1 in grapevine following stem injection biorxiv.org 2026-07-13 Endophytic biocontrol agents may contribute to grapevine health, but their ability to establish, persist, and move within woody tissues remains poorly
The MiDAS global genome catalog: 53,501 long-read MAGs representing all core prokaryotic genera in the global activated sludge microbiome biorxiv.org 2026-07-13 Wastewater treatment relies on complex microbial communities, yet existing genome-resolved references for this essential engineered ecosystem remain d
Isolation and characterization of novel filamentous phages from Swiss-type cheeses infecting the Gram-positive bacterium Propionibacterium freudenreichii biorxiv.org 2026-07-13 Filamentous phages infecting Gram-positive bacteria remain largely unexplored.
Glutamine Metabolism Supports α cell Mass and Glucagon Secretion biorxiv.org 2026-07-13 The liver- cell axis is a finely tuned biological rheostat that regulates whole body amino acid availability.
Contrasting effects of glucose and methylglyoxal supplementation on blood oxidative status, blood cells' telomere dynamics and apoptosis in birds biorxiv.org 2026-07-13 Birds exhibit longer lifespans than similarly sized mammals, despite having higher mass-adjusted blood glucose levels.
PolliCrop: A high-throughput computer vision pipeline for pollinator monitoring in agroecosystems biorxiv.org 2026-07-13 Flower-visiting insect populations are declining since the 1990s, especially because of the decrease of floral resources in agricultural settings.
Does ensembling improve feature attributions from sequence-to-activity models? biorxiv.org 2026-07-13 Sequence-to-activity models take as input DNA sequence and predict genomic activities such as transcription factor binding and gene expression.
Quantum Encoding Strategies for Drug Response Prediction: An Exhaustive Benchmark on a 20-Qubit Superconducting QPU biorxiv.org 2026-07-13 We present the first systematic, hardware-executed benchmark of twelve distinct quantum data-encoding strategies for drug-response prediction on a rea