Systematic Development of a Compact Genome-Editing Tool Leveraging the TAM-Independent DNA Nuclease TasR in Bacillus subtilis biorxiv.org 2026-07-16 Bacillus subtilis is a core microbial chassis in biomanufacturing, and establishing efficient gene editing technologies is key to engineering this str
Spatial Topology Reveals Biologically Distinct Recurrent Motifs in Colorectal Cancer biorxiv.org 2026-07-15 Most spatial transcriptomic analyses of solid tumors focus on individual cell states or single-sample spatial domains rather than on recurrent multice
α5β1 and αvβ3 integrins employ two distinct adhesion strengthening modes to respond to fibronectin stiffness within seconds of initiating adhesion biorxiv.org 2026-07-15 The complex interplay between extracellular matrix stiffness and actomyosin contractility regulates long-term integrin-based adhesion and signaling in
From exact gradients to exact standard errors: third-order sensitivity equations for the FOCE and FOCEI population likelihood biorxiv.org 2026-07-15 Asymptotic standard errors for the parameter estimates of a nonlinear mixed-effects model fitted by first-order conditional estimation (FOCE) or FOCE
Spaceflight-relevant microgravity triggers a sublethal Parkinson's-like dopaminergic decline in human neurons and organoids. biorxiv.org 2026-07-15 Spaceflight stressors may increase Parkinson's disease (PD) risk, but microgravity-specific contribution to human dopaminergic (DA) vulnerability rema
Allele-specific correction of dominant Best vitelliform macular dystrophy in patient-derived retinal pigment epithelium biorxiv.org 2026-07-15 Autosomal dominant Best vitelliform macular dystrophy (BVMD) caused by variants in BEST1 is characterized by dysfunction of the macular retinal pigmen
The Role of Training Paradigms in Shaping Connectivity and Dynamics: A Comparison of Gradient-Based and Evolutionary Methods in Recurrent Neural Network Models biorxiv.org 2026-07-15 Recurrent neural networks (RNNs) trained with backpropagation through time (BPTT) use gradients and global error signals to solve tasks, while evoluti
The plant specific VPS2.2/HYADE of the ESCRT-III protein sorting machinery localizes to a secretory compartment and is required for cell division plane determination in Arabidopsis biorxiv.org 2026-07-16 Positioning of the division plane is a critical step during cellular development.
Neuroanatomical Subtypes of Callous-Unemotional Traits in a Community Sample of Youth biorxiv.org 2026-07-16 Importance.
Structure-based recasting of a mammalian DNA transpososomeas an obligate heterodimer biorxiv.org 2026-07-16 Eukaryotic DNA transpososomes assemble as nucleoprotein complexes containing multiple identical transposase protomers.
Prototype-based AI triage for 3D pathology biorxiv.org 2026-07-15 Non-destructive 3D pathology enables high-resolution slide-free imaging of intact clinical specimens, providing comprehensive visualization of tissue
Effect of Immunosuppressive Drugs on Glucose-Stimulated Insulin Secretion: Concentration-Response Studies in Dynamic Perifusion Assays biorxiv.org 2026-07-15 Immunosuppressive drugs, which are required to maintain graft function in transplant recipients, are associated with many unavoidable side effects inc
Before the eye moves: microsaccade preparation expands spatial integration at the center of gaze biorxiv.org 2026-07-15 Fixation is often treated as a period of stable visual processing.
A Deep Learning Framework for Biomarker Segmentation and Classification in Traumatic Brain Injury biorxiv.org 2026-07-15 Traumatic brain injury (TBI) triggers widespread biomarker activation, including astrocytic markers such as glial fibrillary acidic protein (GFAP) and
From Hummingbird to Elephant: Amyloid Formation in Natural Transthyretin Variants biorxiv.org 2026-07-15 Transthyretin (TTR) is a secreted protein associated with cardiac and other amyloid diseases via misfolding.
Partial epithelial-to-mesenchymal transition mediates profound gap closure through growth and fluidization biorxiv.org 2026-07-15 Epithelial gap closure is essential for maintaining tissue integrity during development and wound healing.
COB: a comprehensive database of chloroplast outer envelope beta-barrel proteins biorxiv.org 2026-07-15 Despite their central role in metabolite exchange, lipid trafficking, and protein import, chloroplast outer envelope beta-barrel proteins lack a dedic
A robust, sensitive phylogenetic method enables gene-level metagenomic analyses biorxiv.org 2026-07-15 A key goal in the microbiome field is to move from taxonomic associations towards mechanistic hypotheses about microbial gene function.
No effects of APOE ε4 on spatial navigation and broader cognition in young adults genetically at risk for Alzheimer's disease biorxiv.org 2026-07-15 Alzheimer's disease (AD) causes progressive memory loss and disorientation.
Pediatric traumatic brain injury elicits acute neuroinflammation and long-term changes in social, cognitive, and decision-making behaviors in male and female rats biorxiv.org 2026-07-15 Traumatic brain injury (TBI) is one of the leading causes of emergency room visits in children under 10.
LARP4 is a B cell-specific metabolic checkpoint for plasma cell differentiation and a therapeutic target in systemic lupus erythematosus biorxiv.org 2026-07-15 RNA-binding protein LARP4 plays an important role in T cell activation and differentiation, but its role in B cell biology and the pathogenesis of sys
A geometric and dynamical theory of latent computations in biological neural networks biorxiv.org 2026-07-15 Many neural recordings have revealed low-dimensional sets of behaviorally relevant variables encoded within large-scale neural activity patterns.
Brain Structural and Resting-state Functional Network Changes Following Expiratory Musculature Targeted Resistance Training in Healthy Young Adults: A Pilot Study biorxiv.org 2026-07-15 Multimodal imaging approaches that combine structural and functional neuroimaging provide a robust framework for examining neuroplastic adaptations th
Flexible predictive control in human interception under visual occlusion and altered gravity biorxiv.org 2026-07-15 Interception of moving objects requires the nervous system to compensate for sensory delays and uncertainty, yet how behavior is controlled remains de
Effects of acute intranasal allergen exposure on resident immune cells and sensory neurons in the mouse olfactory epithelium biorxiv.org 2026-07-15 The main olfactory epithelium (MOE) is the primary site of olfaction and consists of multiple cell types including olfactory sensory neurons (OSNs), s
Boredom and the representation of information content in the neocortex biorxiv.org 2026-07-15 Boredom - a pervasive mental state - promotes the pursuit of novel information by assigning negative value to monotonous conditions.
Coordination Failures Generate Selection Gradients in Animal Collectives biorxiv.org 2026-07-15 Collective animal behavior occurs in high-stakes contexts where failing to coordinate effectively with group-mates can spell disaster for individuals.
Evidence for a Nod-like signalling system in cyanobacterial symbiosis with O. sativa biorxiv.org 2026-07-15 Symbiotic interactions between plants and nitrogen-fixing microorganisms are essential for sustainable agriculture, yet the molecular mechanisms under
Galangin and Caffeic acid inhibit Methylglyoxal-induced Advanced Glycation End Product formation in Bovine Serum Albumin biorxiv.org 2026-07-15 Glycation, a non-enzymatic reaction occurring between sugars and biological macromolecules, plays a critical role in ageing and disease pathogenesis.
Allosteric modulation of β1 integrin through the hybrid domain reverses articular cartilage injury and functional impairment in a murine model of inflammatory arthritis biorxiv.org 2026-07-15 Rheumatoid arthritis is a chronic inflammatory joint disease in which progressive destruction of cartilage and bone drives long-term disability.