Oral Gut Microbial Axis in Inflammatory Bowel Disease and Primary Sclerosing Cholangitis biorxiv.org 2026-07-16 The oral cavity is increasingly recognized as a reservoir of microbes that can translocate to and influence the gut microbiome.
MEN1 deficiency establishes a selenite-dependent binary switch in ferroptosis biorxiv.org 2026-07-16 Replication stress is a driver of cancer cell death, yet how genetic and environmental factors impact cellular tolerance remains unclear.
AMPKγ2 Deacetylation Drives Nuclear Translocation and Doxorubicin-Induced Cardiomyopathy via Nucleolar Stress Signaling biorxiv.org 2026-07-16 Doxorubicin (Dox)-induced cardiomyopathy (DIC), characterized by cardiomyocyte apoptosis, remains a major clinical challenge in chemotherapy.
Ethanol-induced activation of BMP signaling and reprogramming of cardiomyocytes' transcriptome biorxiv.org 2026-07-16 Congenital heart disease (CHD) comprises a diverse group of structural heart defects present at birth due to complex interactions between genetic and
A spatial atlas of the seaweed CO2-fixation machinery reveals a unique Rubisco condensation mechanism biorxiv.org 2026-07-16 Seaweeds (macroalgae) are important primary producers that sustain food webs in coastal ecosystems.
Group Behaviors Foster Zebrafish Foraging Through Social Interaction biorxiv.org 2026-07-16 Group living enhances foraging efficiency, yet whether this benefit extends across developmental stages and how social coordination versus emotional b
Substrate biasing in UCHL5 proteoforms biorxiv.org 2026-07-16 Proteolytic deubiquitinating enzymes bridge a gap in substrate recognition through complex regulatory mechanisms.
Multi-Modal Toxicological Evaluation of NiO nanoparticles and ionic nickel in a Human Lung-Cardiac Co-Culture System biorxiv.org 2026-07-16 Nickel is a widespread environmental and occupational contaminant associated with respiratory and cardiovascular toxicity, yet the mechanisms linking
Ageing of the Upper Airway Epithelial Niche Limits Tissue-Resident T Cell Immunity biorxiv.org 2026-07-16 Respiratory tract infections are a major cause of morbidity and mortality among older adults worldwide.
PEPC Gene Family Evolution Across Arecaceae: Complete Five-Subfamily Evidence for a Two-Lock Model of Irreversible C4 Exclusion biorxiv.org 2026-07-16 Background - C4 photosynthesis has evolved more than sixty times across flowering plants, but never in palms.
Reconstructing sequence-grammar trajectories enables interpretable and tunable cis- regulatory element design biorxiv.org 2026-07-16 Designing synthetic cis-regulatory elements (CREs) with cell-type-specific activity is critical for precision gene and cell therapies, but remains cha
Biological Continued Pretraining Reshapes the Capability Profile of a Foundation Model Without Catastrophic Forgetting biorxiv.org 2026-07-16 It is widely assumed that continued pretraining (CPT) on a narrow, out-of-distribution corpus such as raw biological sequence must trade away a genera
Evaluating the use of non-linear models in data-driven rescoring of peptide-spectrum matches biorxiv.org 2026-07-16 In mass spectrometry (MS)-based proteomics, computational tools match acquired tandem MS spectra to peptides from a sequence database.
Reference Regulatory Element-Guided Gene Expression Analysis for Mechanistic Inference of Gene Regulatory Networks biorxiv.org 2026-07-16 Regulatory genomics faces a depth-breadth gap: deep multi-omics provides regulatory detail but is difficult to scale, whereas broad expression dataset
Differential multi-omics analysis of pulmonary arterial hypertension microvascular endothelial cells for differential drug response biorxiv.org 2026-07-16 Pulmonary arterial hypertension (PAH) represents a heterogeneous group of disorders that involves complex molecular dysregulations, which are not full
CurateMake: an auditable workflow for multi-source ITS reference database harmonisation and phylogenetic validation biorxiv.org 2026-07-16 1. Reference databases shape the taxonomic resolution, uncertainty, and reproducibility of metabarcoding analyses.
SHINE: Decoding transcriptional-metabolic microenvironments through higher-order spatial integration biorxiv.org 2026-07-16 Spatial omics technologies are expanding to co-profile transcriptomics and metabolomics on the same tissue slide, providing complementary views of gen
Increases in serum corticosterone level and diuresis induced by the selective kappa opioid receptor (KOR) agonist U50,488H are unaffected by KOR phosphorylation biorxiv.org 2026-07-16 Purpose: We previously showed that mice expressing a phosphorylation-deficient kappa opioid receptor mutant (K4A) exhibited reduced U50,488H-induced a
Spatio-temporal 3D Mapping of Mouse Cerebellar Vascularization during Embryonic Development biorxiv.org 2026-07-16 Despite major advances in the study of cerebellar neurogenesis, cerebellar angiogenesis during embryogenesis remains poorly described.
What Do Generative Models Learn About Adaptive Immune Receptor Repertoires? A Benchmark Study biorxiv.org 2026-07-16 Generative models are increasingly used to model adaptive immune receptor repertoire (AIRR) sequence distributions, promising to decode the sequence d
Genome-wide association analysis reveals new loci for leaf water status, biomass and plant architectural traits in bread wheat under rainfed conditions biorxiv.org 2026-07-16 Drought during reproductive development and grain filling is a major constraint to bread wheat productivity in rainfed environments.
Integrating suboptimal secondary structures, AI-assisted genomic synteny, and evolutionary conservation to identify bacterial ncRNA homologs beyond sequence similarity biorxiv.org 2026-07-16 A bioinformatic approach for genome-wide identification of homologs of bacterial non-coding RNAs (ncRNAs) integrating structural similarity, genomic s
Surface electrostatic networks control hydrophobic core remodeling in a pH-dependent switching protein biorxiv.org 2026-07-16 Communication between protein surfaces and their buried cores is central to protein structure and function, yet this phenomenon remains challenging to
Impact of Solvent Extraction on Bioactive Properties of Lavandula x intermedia: Antibacterial, Antioxidant and Phenolic Content Analysis biorxiv.org 2026-07-16 Lavandula x intermedia (lavandin) is an economically important hybrid valued for its high essential oil yield; however, studies linking solvent polari
Neural Evidence That Gender-Inclusive Language Attenuates Automatic Gender Predictions biorxiv.org 2026-07-16 Languages vary in whether and how they encode gender.
Right-lateralized prefrontal signature with successful Stroop-like interference control in early childhood biorxiv.org 2026-07-16 The Stroop effect is a canonical measure of executive control, yet its neural architecture has been defined largely in literate children and adults, w
A personalized map of where, when, and how to stimulate the brain to elicit controlled responses biorxiv.org 2026-07-16 Brain stimulation has transformed the treatment of several neurological and psychiatric disorders and is now widely used to read out causal interactio
The nucleus of the lateral olfactory tract is required for learning odor-guided food avoidance biorxiv.org 2026-07-16 Foraging animals must continually evaluate whether potential food sources are safe to consume.
Gut Virome Diversity and Health Status in Rescued Pangolins: Metaviromics Reveals Parvovirus as a Key Virus Associated with Disease biorxiv.org 2026-07-16 Pangolins are critically endangered mammals that suffer from high rates of gastrointestinal disease during captivity, yet the role of the gut virome i
The evolutionary processes of bacterial aromatic polyketide ketosynthases biorxiv.org 2026-07-16 Background: The biosynthesis of bacterial aromatic polyketide polyketides (type II polyketides, T2PKs) employs a single set of catalysts (ketosynthase