Mutation-agnostic gene insertion therapy for RHO-associated autosomal dominant retinitis pigmentosa using zinc finger nucleases biorxiv.org 2026-07-17 Purpose: Autosomal dominant retinitis pigmentosa caused by mutations in the rhodopsin gene (RHO-adRP) is among the most prevalent inherited retinal dy
The ecology of remembering and forgetting: quantity-quality trade-offs in the spatiotemporal memory of a forager biorxiv.org 2026-07-17 One way that animals can cope with the challenge of locating ephemeral food in time and space is by tracking elapsed time and planning revisits to the
A capsule polysaccharide synthesis locus database for the Klebsiella oxytoca Species Complex biorxiv.org 2026-07-17 The Klebsiella oxytoca Species Complex (SC) represents an emerging healthcare-associated group of opportunistic pathogens.
Hidden assumptions in nascent RNA sequencing pipelines define reproducibility states biorxiv.org 2026-07-17 Reproducibility of sequencing analyses is often assumed when identical data are processed with established pipelines, yet outcomes can depend on libra
Large-scale dimensional behavioral profiling dissociates fear memory from locomotor confounds in mice: The necessity of baseline-normalized metrics biorxiv.org 2026-07-17 Fear conditioning is widely used to assess associative memory in mice, yet percent freezing conflates memory with baseline locomotor and anxiety-relat
An Integrated EEG, TMS-EEG and Behavioural Dataset for Investigating the Neural Correlates of Working Memory biorxiv.org 2026-07-17 Working memory is a fundamental process that underlies cognition.
Task-specific neural mechanisms underlie biases in human orientation perception biorxiv.org 2026-07-17 Prior experience shapes both visual perception and its underlying neural circuits.
Macrophage calcium signaling dynamics revealed using genetically-encoded sensors biorxiv.org 2026-07-17 Macrophages (M{varphi}s) inhabit all mammalian organs, adapting to and influencing the tissues in which they reside.
Butyrivibrio azoria sp. nov., a novel cellulolytic microorganism isolated from the rumen of a Holstein dairy cow biorxiv.org 2026-07-17 This study describes the characteristics of NATIVEDY162T (= JL13D10T = NRRL B-68525T) a novel bacterium isolated from the rumen of a healthy Holstein
Addressing viral genomic variability towards developing a Cas13b-based therapy biorxiv.org 2026-07-17 Viral genome diversity may limit the effectiveness of antiviral RNA-editing tools such as CRISPR-Cas13 that can be used to destroy specific mRNA targe
Two-locus CRISPR toxin-antidote gene drive for confined population modification biorxiv.org 2026-07-17 Gene drive systems enable rapid spread of desired transgenes throughout populations.
Evidence of two centromeres in the germline-restricted chromosome (GRC): insights from zebra finch lampbrush chromosomes biorxiv.org 2026-07-17 The germline-restricted chromosome (GRC) of the zebra finch Taeniopygia guttata represents a well-established model of programmed DNA elimination in v
Total Biosynthesis of Pseudomonas aeruginosa-Derived Azabicyclocarbamates Identifies Distinct Dehydrating Condensation Family Proteins biorxiv.org 2026-07-17 Bacterial azabicyclocarbamates and related pyrrolizidine alkaloids play important roles in microbial interactions, and are scaffolds of therapeutic po
Robean: A Standalone Freeware for Automated Rodent Neurobehavioural Analysis with Integrated Tracking, Visualization, and Reporting biorxiv.org 2026-07-17 Quantitative analysis of rodent behaviour is fundamental to neuroscience, preclinical drug discovery and neurotoxicology research.
Pannexin 1 phosphorylation sites differentially modulate channel activity and physiological outcomes biorxiv.org 2026-07-17 Within the vasculature, pannexin 1 (PANX1) channels in smooth muscle cells (SMCs) regulate -adrenergic constriction and blood pressure.
A validated neuronal SH-SY5Y platform reveals critical experimental variables for reproducible Aβ 1-42 self-assembly neurotoxicity assessment biorxiv.org 2026-07-17 Reliable in vitro evaluation of amyloid-{beta} (A{beta}) toxicity is essential for the development of anti-amyloid therapeutics, yet experimental work
Autonomic challenge uncovers hidden link between diastolic blood pressure and mental imagery vividness biorxiv.org 2026-07-17 Mental imagery is viewed as a fundamental component of human cognition, supporting memory, emotional processing, future simulation, and conscious expe
Resolving early cochlear inflammation prevents lasting damage from noise exposure biorxiv.org 2026-07-17 Noise-induced hearing loss (NIHL) is a leading cause of permanent hearing impairment worldwide, yet no pharmacological therapies are currently availab
Abdominal-B neurons selectively drive vibrations in Drosophila biorxiv.org 2026-07-17 Male Drosophila courtship includes two communication signals: airborne song and substrate-borne vibrations.
How specific structural differences of Bcl2 proteins modulate the interaction with BH3 domains and apoptotic function biorxiv.org 2026-07-17 Intrinsic apoptosis is mainly regulated through a network of conserved interactions between Bcl-2 proteins involving hydrophobic binding grooves and B
Multi-modal MRI characterisation of vascular remodelling, muscle fibre integrity, and inflammatory recovery in a hindlimb ischaemia mouse model biorxiv.org 2026-07-17 The hindlimb ischaemia (HLI) mouse model is a widely used preclinical model of chronic limb-threatening ischaemia (CLTI).
E-HAPLOS: Electrical Impedance Human-guided Assesment with Pressure for Lump Observation System biorxiv.org 2026-07-17 Breast cancer is the leading cause of cancer-related deaths among women in the Philippines.
Food Ration Affects mRNA Processing, Translation, Proteostasis, and Cytoskeletal Responses During Heat Shock in Mytilus californianus biorxiv.org 2026-07-17 Despite a likely role in setting stress tolerance limits, food ration has received limited attention as an ecological factor affecting the cellular st
Glial subcellular specialisation resolved with high resolution spatial transcriptomics biorxiv.org 2026-07-17 Cells in the brain have complex structures with extended processes.
Computational Counterfactuals Reveal Non-Additive Audiovisual Semantics in Natural Movie Responses biorxiv.org 2026-07-17 Natural audiovisual perception may not be fully captured by decomposing movies into auditory and visual streams.
Textural features for pathway-level representation of omics data in biological networks biorxiv.org 2026-07-17 More than 50 years ago, Haralick and co-authors proposed a family of gray-level co-occurrence statistics that became known as textural features.
Mapping absolute membrane voltage using dynamic photocycle control biorxiv.org 2026-07-17 Fluorescent voltage indicators are widely used to report relative changes in membrane potential, but mapping absolute voltages remains difficult.
Mechanosensation, habituation, and behavioural plasticity in tintinnid ciliates biorxiv.org 2026-07-17 Unicellular organisms sense, integrate and respond to environmental cues despite lacking neurons or a nervous system.
Excited state Relaxation Activation Energy (ESRAct) of Di-4-ANEPPDHQ Maps Nanoscale Molecular Organization in Biomembranes biorxiv.org 2026-07-17 Live cell plasma membranes show spatially heterogeneous liquid-ordered (Lo)-like and liquid-disordered (Ld)-like regions similar to the co-existing Lo
Coarse-grained simulations of long intrinsically disordered proteins: a benchmark of Martini 3 force-fields biorxiv.org 2026-07-17 Martini 3 is a force field ideally suited to simulating long intrinsically disordered proteins (IDPs) in cell-like surroundings.