Antibody-drug conjugate combination therapy targeting LGR5 and MET with different payloads enhances efficacy in preclinical colorectal cancer models biorxiv.org 2026-07-20 Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a marker of cancer stem-like cells frequently upregulated in colorectal cancer (
FLD Is Required for N-Hydroxypipecolic Acid Accumulation and Associated Growth Defects in Arabidopsis pmr4 Mutant biorxiv.org 2026-07-20 The Arabidopsis mutants lacking the pathogen-inducible callose synthase POWDERY MILDEW RESISTANCE 4 (PMR4)/GLUCAN SYNTHASE-LIKE 5 (GSL5) exhibit enhan
TurboID-based proximity-dependent labeling using SOBIR1 as a bait in potato leads to the identification of novel defense-related signaling partners biorxiv.org 2026-07-20 The plant immune system comprises a complex signaling network that is activated upon perceiving molecules derived from invading pathogens.
Psychedelic drug action at dendrites is gated by behavioral state and serotonin receptors biorxiv.org 2026-07-20 How psychedelics act on cortical dendrites to produce long-lasting structural plasticity remains poorly understood.
The Physics Network is Distinct from the Multiple Demand System in the Human Brain biorxiv.org 2026-07-20 Recent studies implicate regions of the human bilateral fronto-parietal cortices in intuitive physical reasoning -- our ability to perceive, predict,
Enkephalin constrains fear learning via volume transmission to the lateral amygdala biorxiv.org 2026-07-20 Fear learning involves the formation of associations between cues and aversive outcomes, a process that must be tightly regulated to prevent excessive
Spectral organization of individualized connectome harmonics across brain structure, function and cognition biorxiv.org 2026-07-20 Connectome harmonics provide a spectral representation of structural brain connectivity that has emerged as a powerful framework for studying structur
Molecular and cell type-specific determinants of inferior colliculus development and auditory function biorxiv.org 2026-07-20 Sound perception requires sensory information processing through brain regions where alterations to cellular composition or function may impact audito
Deep learning representations of human Immune Health for precision immunology biorxiv.org 2026-07-20 The human immune system is composed of [~]30-50 distinct cell types, each of which can exist in different states of activation or differentiation.
FOXO/DAF-16 modulates the transcription factor ROR/NHR-23 and inhibits the let-7 microRNA to maintain multipotency during dauer biorxiv.org 2026-07-20 Animals rapidly reprogram gene expression to adapt development to environmental stress.
SMART: A Somatic Mutation Annotation and Reporting Tool for cancer genomics biorxiv.org 2026-07-19 Motivation: Translational interpretation of somatic variants from targeted oncology panels is hampered by inconsistent transcript prioritisation and b
Rho ({rho}) Analysis to Dissect RNA Folding and Assembly Pathways biorxiv.org 2026-07-19 The modular structure and energetics of RNA simplifies its folding.
Quantifying Cross-Modal Shared Information Between Histomorphology and Spatial Transcriptomics via Spatiotemporal Trajectory Correlation biorxiv.org 2026-07-19 Histopathological imaging and spatial transcriptomics (ST) provide synergistic morphological and molecular insights into tissue architecture.
Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays biorxiv.org 2026-07-19 Volume-regulated anion channels (VRACs), formed by leucine-rich repeat-containing 8 (LRRC8) proteins, are ubiquitously expressed chloride channels ess
Investigating the mechanism of resistance to indaziflam in Poa annua biorxiv.org 2026-07-19 Indaziflam is an effective herbicide for controlling Poa annua, a weed, in turfgrass, orchards, and rangelands.
In silico framework for benchmarking optogenetic hearing restoration biorxiv.org 2026-07-19 Background.
Non-invasive Vagal Nerve Stimulation as a Potential Treatment for Repetitive Blast Trauma biorxiv.org 2026-07-19 Background: Polytrauma caused by exposure to high explosives (blast) is increasingly common among military personnel and civilians yet treatment for r
A novel rat model of body first subtype of Parkinsons disease biorxiv.org 2026-07-19 The recent growing evidence support the existence of two subtypes of Parkinsons disease (PD), a body first and brain first subtype owing to variabilit
Jamaican fruit bats are susceptible to henipaviruses but rapidly control infection biorxiv.org 2026-07-19 Henipaviruses (HNV), Hendra (HeV) and Nipah (NiV) virus, cause severe pulmonary and neurologic disease in humans and other mammals.
Extended floral longevity does not increase seed production under experimental pollinator decline biorxiv.org 2026-07-19 Premise of research: In plant species that depend on pollinators to produce seeds, declines in pollinator populations should strengthen natural select
Insulin-degrading enzyme activity is modulated by interaction with pyrroline-5-carboxylate reductase 1 biorxiv.org 2026-07-19 Insulin-degrading enzyme (IDE, insulysin, insulinase) is a peptidase that hydrolyzes a number of bioactive peptides including insulin and the amyloid
EndoAge Atlas: Non-linear dynamics of endothelial aging reveal organ-specific vascular trajectories in mice biorxiv.org 2026-07-19 Aging is a complex and multifactorial condition that leads to a gradual decline in organ functions and subsequent vulnerability to various diseases.
Best for the Eye, Not for the Algorithm: Anisotropy in Fitting Atomic Models in Cryo-EM biorxiv.org 2026-07-19 Most atomic model refinement methods in cryo-EM fit models to the reconstructed density map and effectively treat Fourier voxels as equally reliable.
An aptamer targeting TfR1 enhances ASO delivery to muscle tissue biorxiv.org 2026-07-19 Oligonucleotide based therapeutics continue to rise as a significant class of medicines for the treatment of human disease.
Human-Relevant Lead Exposure During Differentiation Alters the Transcriptomic Profile of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes biorxiv.org 2026-07-19 Cardiovascular disease (CVD) etiology is strongly influenced by lead (Pb) exposure, but the underlying molecular and functional mechanisms are unclear
Motor Occupancy Defines Emergent Mechanical States in Cardiac Myosin Ensembles biorxiv.org 2026-07-19 Myosin II generates force through the collective action of mechanically coupled motor ensembles, yet the mechanisms by which these ensembles sense cha
Emergent, cost-free surplus of core biosynthesis governs bacterial fitness biorxiv.org 2026-07-19 Cells often express essential components in excess of the levels required to sustain steady-state growth.
Microbiota-sensitive glial and metabolic programs define a critical window in early postnatal brainstem development biorxiv.org 2026-07-19 Paediatric brain tumours are increasingly recognised as diseases of disrupted development, arising when lineage progression programs, that normally go
Deep anatomical and ultrastructural classification of neurons in the zebrafish olfactory bulb biorxiv.org 2026-07-19 Neuronal circuits in the olfactory bulb (OB) perform computations fundamental to pattern classification including a decorrelation and normalization of
An Inverse Transwell Assay for Airway Mucus Barrier Function Reveals both Virus- and Mucin-Specific Impacts on Infection biorxiv.org 2026-07-19 Respiratory viruses are a significant cause of morbidity and mortality world-wide and an important trigger of acute exacerbation in chronic lung disea