A Bayesian method for estimation of plant soil water content with application to low-cost horticultural robotics biorxiv.org 2026-07-20 Climate change represents a challenge to food security by interfering with the environmental conditions needed for productive plant growth.
Developmental stage-dependent decoupling of molecular and phenotypic responses to heat in wheat grain biorxiv.org 2026-07-20 Heatwaves during flowering and grain development threaten global wheat production, yet the extent to which developmental stage shapes molecular and ph
Exercise Myokine Irisin Enables Behavioral Stress Resistance in Mice biorxiv.org 2026-07-20 Physical activity produces widespread benefits to physical and mental health, including protection against stress-related behavioral outcomes.
Alcohol Cues Invigorate Aversion-Resistant Alcohol Drinking biorxiv.org 2026-07-20 Background: Alcohol use disorder is characterized by continued alcohol use despite negative consequences, also known as aversion-resistant drinking.
Neural Representations of Ensemble Mean and Variance Across Visual Features biorxiv.org 2026-07-20 Humans can rapidly extract summary statistics, such as the mean and variance of visual features, to efficiently represent complex visual environments
When does more data help? Spectral Geometry and Scaling Laws in MRI Transformers biorxiv.org 2026-07-20 Scaling laws describe how model performance improves as the amount of training data increases, and recent theories such as the zeta law suggest that s
The All Window-Size Search method for improved statistical power in multiple comparisons correction biorxiv.org 2026-07-20 Correcting for multiple comparisons is a fundamental challenge throughout the biological sciences, particularly for data sampled over ordered continua
cf-Cabernet: Nick Repair Prior to End Repair Preserves Endogenous DNA Methylation Information in Cell-Free DNA Methylation Sequencing biorxiv.org 2026-07-20 Cell-free DNA (cfDNA) methylation profiling holds great promise for non-invasive cancer detection, yet accurate methylome analysis is compromised by D
Anticipatory discovery of entry inhibitors against emerging viruses guided by viral phylogeny biorxiv.org 2026-07-20 Emerging viruses pose a major threat to global health, underscoring the need to improve antiviral preparedness.
Long-term SARS-CoV-2 Persistence in Syrian Hamsters biorxiv.org 2026-07-20 SARS-CoV-2 persistence has been proposed as a potential contributor to the pathogenesis of long COVID, with reservoir tissues potentially serving as s
CreaSol(R) SSAT (Stabilized Tyrosol) Enhances Creatine on Muscle Performance and Anti-fatigue Capacity in Trained Mice biorxiv.org 2026-07-20 Tyrosol, a natural polyphenolic compound, has been identified as a potent cellular antioxidant.
Muscle mass and denervation explain variability in maximal power and rapid force across the adult female lifespan biorxiv.org 2026-07-20 Background: Dynamic power declines earlier across the lifespan and shows a more pronounced and complex pattern than isometric strength, particularly i
Autonomic and cortical responses to heartbeat-synchronous auditory omissions during an auditory attention task biorxiv.org 2026-07-20 Cardiovascular regulation depends on bidirectional communication between autonomic cardiac control and cardiac afferent signals ascending to the centr
Region-Specific Delta and Alpha2 Relative Power Alterations in Male Adolescent Schizophrenia: Occipital Predominance in Resting-State EEG biorxiv.org 2026-07-20 Resting-state electroencephalography (EEG) studies consistently report increased slow-wave activity and reduced alpha power in schizophrenia.
Effect of Spatial Release from Masking on Listening Effort in Different Semantic Contexts biorxiv.org 2026-07-20 Humans often communicate and learn in noisy, complex listening environments.
Closed-loop control of in vitro neuronal activity using reinforcement learning after in silico pre-training biorxiv.org 2026-07-20 Controlling specific neuronal dynamics with electrical stimulation is critical for therapeutic neuromodulation, yet deriving optimal control policies
The Q1K Integrated EEG and Eye-Tracking Experimental Test Battery for Open Autism Science biorxiv.org 2026-07-20 The Quebec 1000 Families (Q1K) platform has been designed to recruit, phenotype, and collect biospecimens from a large cohort of families with at leas
Selection navigates a degenerate circuit space: behavioral individuation without structural differentiation in constrained neuroevolution biorxiv.org 2026-07-20 Neural degeneracy, the capacity of structurally distinct circuits to perform the same function, is typically studied as an emergent property of biolog
Interconnected reservoirs of multidrug-resistant bacteria and plasmids within the hospital built environment biorxiv.org 2026-07-20 Hospital sinks and wastewater streams are hotspots for contamination and colonization with multidrug-resistant Gram-negative bacteria (MDR-GNB).
GDTR: Layer-wise Settling Depth Reveals Biological Grammar in Genomic Foundation Models biorxiv.org 2026-07-20 Genomic foundation models capture sequence regularities, yet existing interpretability tools rarely ask where in the layer stack a biological grammar
EBD-DTI: Episodic Bridge Diffusion for Zero-Shot Cold-Start Drug-Target Interaction Prediction biorxiv.org 2026-07-20 Predicting drug-target interactions (DTI) for entirely unseen drugs or proteins---the cold-start problem---remains a critical challenge in computation
Neocortical astrocyte diversity stems from distinct developmental origins biorxiv.org 2026-07-20 Key regulators of neural network activity in multiple advanced cognitive processes and essential components of the blood-brain barrier, astrocytes con
Diversity and evolution of the transcriptional regulatory networks of Pseudomonas strains revealed using machine learning biorxiv.org 2026-07-20 The genus Pseudomonas consists of diverse and ecologically significant species that form close associations with both plants and animals.
Patient-Derived Inner Ear Organoids as a Disease Modeling and Therapy Validation Platform For Hereditary Inner Ear Disorders biorxiv.org 2026-07-20 Background Hereditary inner ear disorders comprise a highly heterogenous group of disorders and are a major cause of hearing and vestibular dysfunctio
The Human Rectus Femoris Muscle Receives an Independent Common Synaptic Input During Isometric Leg Extensions biorxiv.org 2026-07-20 The distribution of common synaptic inputs across spinal motor neuron pools within and across synergist muscles reveals direct insight in the neural c
Rhythmic expression of a cAMP phosphodiesterase switches neuronal excitability states in the mammalian suprachiasmatic nucleus biorxiv.org 2026-07-20 How the transcriptome of a neuron determines its electrophysiological properties and how this change in different contexts are major questions in neur
Immunoproteasome Deficiency Impairs Microglial Clearance and Worsens Tau and Amyloid Pathology biorxiv.org 2026-07-20 Immunoproteasome induction is prominent in Alzheimers disease (AD), but whether it protects proteostasis or amplifies neuroinflammation remains unreso
Ferulic acid eicosyl ester enhances cognitive flexibility and modulates arousal-related neural circuits in mice biorxiv.org 2026-07-20 Cognitive deficits are a major contributor to disability in numerous neuropsychiatric and neurodegenerative disorders, yet effective pharmacological t
Ensembles of in silico structures enable T cell peptide-MHC binding prediction biorxiv.org 2026-07-20 Adaptive immunity relies on T-cell receptor (TCR) recognition of peptides presented by the major histocompatibility complex (pMHC).
Development and behavior of Steinernema hermaphroditum nematodes are impacted by a bacterial flavin monooxygenase biorxiv.org 2026-07-20 Beneficial animal-microbe symbioses occur across the tree of life, with observable impacts on animal development and behavior.