Stratified Immune Profiling Uncovers Prognostic Heterogeneity Beyond MYCN Amplification and Age in Neuroblastoma biorxiv.org 2026-07-21 Neuroblastoma is the most common extracranial solid tumor in children, presenting remarkable clinical heterogeneity with survival outcomes ranging fro
Thymus Involution across the Human Menstrual Cycle biorxiv.org 2026-07-21 Importance: Thymic involution in humans has traditionally been conceptualized as a linear, age-associated process.
Slow stress-load accumulation dominates BDNF-dependent gain in a ten-state computational model of stress biochemistry biorxiv.org 2026-07-21 Background.
Co-option of CENP-A for activity-induced neuronal plasticity biorxiv.org 2026-07-21 Neuronal activation drives activity-dependent gene expression that underlies experience-associated synaptic modifications, learning and memory.
Estimating trial-wise modulation of functional connectivity using event-related fMRI biorxiv.org 2026-07-21 Understanding the neural basis of human cognition requires measuring not only localized brain activity but also how functional interactions between br
GeneAutomate: A Browser-Based, Integer-Indexed Platform for Dual-Gene-List Functional Annotation and Interactive Network Visualization biorxiv.org 2026-07-21 Comparative interpretation of two gene lists, for example, two treatment arms, two tissues, or a discovery and a validation cohort, is a routine task
COSMOS: A FAIR-aligned infrastructure for clinical trial data validation, warehousing, and interactive discovery biorxiv.org 2026-07-21 The Clinical Omics System for Metadata and Outcome Storage (COSMOS) is an open-source, FAIR- and GCP aligned clinical trial unit (CTU) infrastructure
Extracellular Matrix Proteomic Signatures Associate with Disease-Free Survival in Later Events of Ductal Carcinoma In Situ or Invasive Breast Cancer biorxiv.org 2026-07-21 Background: Ductal carcinoma in situ (DCIS) is a noninvasive breast lesion with variable risk of progression to invasive breast cancer (IBC).
HDAC3 inhibitor RGFP966 acts on the NF-kB pathway and enhances memory persistence in a biphasic manner biorxiv.org 2026-07-21 Nearly five decades ago, it was first observed that long-term memory consolidation requires waves of transcriptional activity and protein synthesis, w
Synaptic Development of Fine Spatial Scale Organization of Neuronal Orientation Tuning in Mouse Primary Visual Cortex biorxiv.org 2026-07-21 Primary sensory cortices often organize neurons with similar stimulus preference into spatially functional maps.
Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality biorxiv.org 2026-07-21 Chemical modifications expand the functional repertoire of nucleic acids, but the extent to which complex glycans can be integrated into genetic polym
Protective effects of a novel RIPK3 antagonist against neutrophil necroptosis and formation of neutrophil extracellular traps biorxiv.org 2026-07-21 Functionally competent, highly purified neutrophils were isolated from healthy human donors.
Rapid removal of nuclear aggregates via proteasome- and VCP-dependent disaggregation biorxiv.org 2026-07-21 Cells use multiple protein quality control (PQC) mechanisms to counteract the toxic effects of protein aggregation caused by cellular stress, ageing o
Dynamic diffusion analysis of the yeast plasma membrane using Airyscan based microscopic techniques biorxiv.org 2026-07-21 The yeast plasma membrane (PM) is highly compartmentalised into distinct nanoscale domains.
Single-Cell Proteomics Reveals Heterogeneous and Bimodal Proteome Responses to DNA Damage biorxiv.org 2026-07-21 DNA damage response (DDR) involves coordinated activation of repair, checkpoint, and stress adaptive signalling pathways following genomic toxicity.
Transcriptional regulation by Tbx2 paralogs creates diversity within photoreceptor subtypes biorxiv.org 2026-07-21 Photoreceptors are retinal neurons whose subtype-specific opsin expression and mosaic organization enable parallel encoding of spectral and spatial vi
Spatial Patterning of Otic Vesicles in Human Inner Ear Organoids biorxiv.org 2026-07-21 During development axial patterning of the otic vesicle sets up the blueprint for the adult inner ear.
Dynamic knowledge representation of blood brain barrier activation, injury and restitution with a novel agent-based model biorxiv.org 2026-07-21 The blood brain barrier (BBB) tightly regulates the interface between the central nervous system and the systemic circulation.
Thermal variability interacts with infection load and the evolution of host-parasite defense biorxiv.org 2026-07-21 Rising temperatures and unpredictable weather patterns are directly linked to emerging infectious diseases that threaten global biodiversity.
Fat body CLOCK restrains innate immunity and maintains survival under dietary stress in Drosophila biorxiv.org 2026-07-21 Both aging and a high-fat diet (HFD) dampen circadian gene transcription rhythms and promote chronic inflammation.
Riverine input and eddy edge effects on microeukaryotic biodiversity in the Northern Gulf biorxiv.org 2026-07-21 Marine microorganisms drive the biogeochemical processes that sustain ocean ecosystems, such as primary production, nutrient cycling, and the transfer
Termination dynamics set RNAPII elongation rate and gate the response to CDK12 inactivation biorxiv.org 2026-07-21 The transcriptional fidelity of RNA polymerase II (RNAPII) is governed by a tight equilibrium between elongation and termination activities, a balance
DNA Polymerase beta Accelerates Cellular DNA Base Excision Repair by Suppressing Excessive PARP1 Engagement biorxiv.org 2026-07-21 DNA polymerase beta (POLB) is required for rapid rates of cellular DNA base excision repair (BER).
Comprehensive landscape of potential CTCF-binding sites across the complete telomere-to-telomere human genome biorxiv.org 2026-07-21 CCCTC-binding factor (CTCF) is a master regulator of the human genome, directly modulating both transcription and 3D genome organization.
Combining Stability-Centered Atomistic Design with Machine Learning for Targeted Enzyme Optimization biorxiv.org 2026-07-21 FuncLib and high-throughput FuncLib (htFuncLib) generate diverse, functional protein libraries using a stability-centered design; however, this substr
Physiological Cross-Sectional Surfaces: A Method for Estimating Muscle Functional Capacity from 3D Digital Models of Fiber Architecture biorxiv.org 2026-07-21 Physiological cross-sectional area (PCSA) is defined as the summed cross-sectional area of all muscle fibers contracting in parallel and at optimal le
Distinct Effects of the Extracellular Matrix on Tumor Organization and Response to Cancer Virotherapy biorxiv.org 2026-07-21 Extracellular matrix (ECM) regulates tumor architecture and immune accessibility, but its impact on virus-based anticancer therapies is not well under
Rapid reconstitution and kinase-controlled regulation of algal pyrenoid condensates in engineered Nicotiana benthamiana biorxiv.org 2026-07-21 The pyrenoid is an organelle found in nearly all algae that concentrates CO2 around Rubisco to enhance photosynthetic carbon fixation.
miR-10a-5p as a critical molecular regulator of dopaminergic impulsivity in the nucleus accumbens biorxiv.org 2026-07-21 Impulsive-compulsive disorders (ICDs), including pathological gambling, hypersexuality, and compulsive buying, are frequently precipitated by dopamine
Evolutionary trade-offs between growth and reproduction under obesogenic conditions: sex-biased skeletal and gonadal maturation in mice biorxiv.org 2026-07-21 Adolescence is a brief period during which finite energy resources are reallocated from linear growth toward reproductive maturation.