Neural correlates of the subjective experience of free-will during value-based risky decisions: a pilot study biorxiv.org 2026-07-17 Underlying the very notion of choice is the fundamental idea of free-will, which is challenged by decision-neuroscience aiming to explain and predict
Multiscale learning and topological analysis across complex postures enable robust nematode size quantification in pharmacological assays biorxiv.org 2026-07-17 Body size is an important trait that reflects animal development and physiology.
Integrating activation-induced costimulation and cytokine signals enhance TCR-based cell therapies biorxiv.org 2026-07-17 TCR based cell therapies offer broad targeting of tumor antigens with high sensitivity but often low durability due to insufficient costimulation (sig
ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity biorxiv.org 2026-07-17 Natural Killer (NK) cell desensitization induced by persistent stimulation limits durable antitumor immunity, yet the molecular mechanisms governing t
Frequent errors are the worst: robustness to individual failures in collective foraging biorxiv.org 2026-07-17 The collective behavior of complex systems emerges from the actions and interactions of their individual components.
Recent social loss, not chronic isolation, reshapes sleep in Drosophila biorxiv.org 2026-07-17 Drosophila melanogaster is widely used to study social experience, yet it remains unclear whether sleep phenotypes attributed to isolation reflect chr
Turning an object into a scene: buildings activate scene-selective visual cortex independently of visual features biorxiv.org 2026-07-17 Human visual cortex contains regions that selectively respond to both scenes and large objects, particularly buildings.
Habitat specialization structures population divergence and demographic variation in Amazonian floodplain birds biorxiv.org 2026-07-17 Understanding how species respond to environmental change requires linking ecological traits to gene flow and demographic history across dynamic lands
Rapid expansion overcomes inbreeding in cross-hemisphere colonization of Barn Swallows biorxiv.org 2026-07-17 Switching migratory behavior appears to promote speciation in birds through colonization of their wintering grounds for breeding.
A hybrid approach combining a phylogenetic method and Approximate Bayesian Computation Random Forest for phylogenetic network inference: application to the rice domestication process in Asia biorxiv.org 2026-07-17 Asian rice is one of the best documented crops in terms of genetic diversity.
MetaboXcan: A multiomic framework linking genetically predicted metabolites, gene expression, and complex traits biorxiv.org 2026-07-17 Genetically regulated molecular phenotypes, such as gene expression and metabolites, are widely thought to mediate the effect of disease-relevant gene
Assembling and annotating the Tainung 67 rice genome to trace its japonica and indica ancestries biorxiv.org 2026-07-17 Here we reported the 409.0 Mb assembly of the Tainung 67 (TNG67) genome, an early hybrid of japonica and indica cultivars.
VDAC2 stabilizes a membrane-inserted, primed intermediate of BAX activation biorxiv.org 2026-07-17 BAX is a major effector of mitochondrial apoptosis and is activated through a series of conformational transitions that lead to mitochondrial outer me
Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues biorxiv.org 2026-07-17 N-acylethanolamines (NAEs), including the endocannabinoid anandamide, are bioactive fatty acid amides that are normally hydrolyzed by fatty acid amide
Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models biorxiv.org 2026-07-17 The development of cancer immunotherapies requires preclinical models that capture intravenous delivery, immune cell recruitment and intratumoral T ce
Modelling phenotypic plasticity in cancer invasion and metastasis: from microscopic interactions to macroscopic dynamics biorxiv.org 2026-07-17 Cancer progression is driven by the interplay between cancer cell phenotypic variability regulated by EMT/MET, and cell-cell and cell-matrix interacti
It takes two to tango: evolutionary divergence and functional interplay of AZG1 and AZG2 cytokinin transporters biorxiv.org 2026-07-17 The evolution of complex plant body architectures required the refinement of hormone transport networks, yet the evolutionary origins and functional d
FIRST EVIDENCE OF PRESENCE OF RALSTONIA SOLANACEARUM IN THRIPS HAWAIIENSIS (THYSANOPTERA: THRIPIDAE) IN INDANG, CAVITE biorxiv.org 2026-07-17 Bugtok disease remains a major bacterial constraint of cooking banana production in the Philippines and is characterized by vascular discoloration, fr
Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint Restraining Streptococcus pneumoniae Invasion of Respiratory Epithelial Barriers biorxiv.org 2026-07-17 Streptococcus pneumoniae rapidly translocates across polarized human bronchial epithelial barriers, with viable bacteria recovered from the basolatera
Zinc Starvation Drives Respiratory Remodeling and Metabolic Adaptations Associated with Cystic Fibrosis in Pseudomonas aeruginosa biorxiv.org 2026-07-17 Host nutritional immunity restricts microbial growth by altering metal availability.
Nuclear acetyl-CoA production by acetyl-CoA synthetase enables dynamic histone acetylation and gene expression in Plasmodium falciparum biorxiv.org 2026-07-17 A complex transcriptional cascade drives the two-day intraerythrocytic developmental cycle of the most virulent human malaria parasite, Plasmodium fal
Exosome-mediated LNA anti-miR delivery achieves potent miR-21 inhibition and PTEN restoration in podocytes. biorxiv.org 2026-07-17 Background Podocyte injury and loss are central drivers of chronic kidney disease (CKD) progression and are involved in the majority of glomerular dis
Genetically interacting mutations and mechanical stress affect the stochasticity of developmental eye defects in yap1 mutants biorxiv.org 2026-07-17 Congenital abnormalities of eye formation show remarkably variable penetrance with phenotypes even varying between left and right eyes.
Absolute quantitative proteomics guides patient-stratified drug repurposing in clear cell and papillary renal cell carcinoma. biorxiv.org 2026-07-17 Background Renal cell carcinoma (RCC) is a highly heterogeneous disease in which distinct molecular subtypes exhibit characteristic genomic, metabolic
Cisplatin-Induced Plasticity Drives Cross-Resistance to CDK4/6 Inhibitors and Reveals Targetable Vulnerabilities Through HDAC Inhibition in Esophageal Squamous Cell Carcinoma. biorxiv.org 2026-07-17 Esophageal squamous cell carcinoma (ESCC) accounts for 90% of esophageal cancer cases worldwide and carries a poor prognosis, with overall survival be
Molecular organization of the Chlorella sorokiniana pyrenoid biorxiv.org 2026-07-17 To overcome the enzymatic limitations of Rubisco, algae operate CO2-concentrating mechanisms (CCMs) that deliver concentrated CO2 to Rubisco tightly p
Differential Metabolite Production Underlies Disruption of the Cystic Fibrosis Airway Microbiota by Pathogens biorxiv.org 2026-07-17 Cystic fibrosis (CF) is a multisystem disease characterized by the accumulation of mucus in the airways that promotes pathogen colonization, leading t
Age-Related Increases in 40Hz Neural Synchrony Are Specific to Typical Development: A Cross-Sectional Study of Autism Spectrum Disorder biorxiv.org 2026-07-17 Background: The 40Hz auditory steady-state response (ASSR) is a measure of gamma-band neural synchrony sensitive to excitation-inhibition (E/I) balanc
Deciphering the Streptococcus mutans essentialome: multi-omic resolution of hypothetical genes and identification of a functional RocS equivalent biorxiv.org 2026-07-17 Genome-wide viability catalogs produced by transposon sequencing (Tn-seq) and CRISPR interference (CRISPRi) have successfully mapped the essential gen
Stabilising effect of modularity in antagonistic networks depends on intraguild interactions biorxiv.org 2026-07-17 Existing literature on ecological networks provides valuable insights into the structure-stability relation of antagonistic, mutualistic or competitiv