Ultrafast light sensing mediated by dermal iridophores in the silverside fish Hypoatherina tsurugae biorxiv.org 2026-07-17 Light-induced body color changes and direct optical sensing in the skin of amphibians and fishes have been debated for more than half a century.
Decoding the oxytocinergic and behavioral signatures of milk ejection biorxiv.org 2026-07-17 Oxytocin-mediated milk ejection (ME) is pivotal to effective breastfeeding and productive health, yet behaviorally decoding and revealing neural mecha
Task-Based Value Generalization Correlates With Positive Overgeneralization and Bipolar Symptoms biorxiv.org 2026-07-17 Positive overgeneralization -- the tendency to generalize from specific successes to broad expectations of future reward -- has been linked to vulnera
Can the heartbeat-evoked potential (HEP) be separated from Cardiac Artefact (CA) using beamforming? biorxiv.org 2026-07-17 The heartbeat-evoked potential (HEP), a cortical response to heartbeats and a neural marker of interoception, is increasingly considered clinically re
Amplitude-Modulated Kilohertz Stimulation Targeting Beta-Band Activity Disrupts Motor Learning biorxiv.org 2026-07-17 Sensorimotor learning is associated with the modulation of neural rhythms in the primary motor cortex (M1).
Edge controllability is associated with treatment response to repetitive transcranial magnetic stimulation in depression. biorxiv.org 2026-07-17 Repetitive transcranial magnetic stimulation (rTMS) is an established treatment for major depressive disorder (MDD), yet variability in treatment resp
Quorum sensing underlies the establishment and maintenance of marginal zone B cells biorxiv.org 2026-07-17 The marginal zone (MZ) of the spleen harbors B cells that play an indispensable role in immune defense, orchestrating rapid responses to blood-borne p
A machine learning model predicts protein stability of annotated and alternate protein isoforms biorxiv.org 2026-07-17 The regulation of protein stability is essential for cellular homeostasis and is determined by a combination of intrinsic sequence motifs and extrinsi
Targeting cellular senescence alleviates bone marrow aging biorxiv.org 2026-07-17 Aging of the hematopoietic system impairs hematopoietic stem cell (HSC) function and alters bone marrow niche behavior, increasing susceptibility to a
Self-thresholding hierarchical outlier-detection for animal movement tracks biorxiv.org 2026-07-17 1). Erroneous locations are ubiquitous in animal tracking data and prove notoriously difficult to remove, particularly so in an unsupervised manner.
Cessation of diel vertical migration by an inshore dinoflagellate bloom under prey deprivation biorxiv.org 2026-07-17 Many dinoflagellates are mixotrophic and regulate their vertical position to navigate dynamic gradients in light, nutrients, and prey.
From wings to tails: the aspect ratio of propulsive surfaces as a general proxy for vertebrate dispersal potential biorxiv.org 2026-07-17 Dispersal influences many fundamental processes, however, direct measures of dispersal are scarce for most taxa, limiting our ability to evaluate ecol
ClimLimits: a global database of multivariate realized climate limits for animal species biorxiv.org 2026-07-17 Introduction and Aim: Assessing the realized climate limits for a species based on the climate conditions (i.e., different aspects of temperature and
Widespread decoupling between abundance and genetic diversity, and strong local genetic structuring in marine unicellular eukaryotes biorxiv.org 2026-07-17 How abundance, connectivity, and genetic diversity covary across space remains a central question in evolutionary biology.
Shifting resource limitation explains multiphasic patterns of density dependence biorxiv.org 2026-07-17 Several recent studies have presented sublinear density dependence as a universal phenomenon across species, driven by factors unrelated to resource l
A conundrum of pleiotropy: GWAS-derived pleiotropy is weakly negatively associated with co-expression network centrality in Arabidopsis thaliana biorxiv.org 2026-07-17 Pleiotropy, the influence of a single gene on multiple phenotypic traits, is a fundamental feature of genetic systems but remains difficult to quantif
Hybrid breakdown is temporary and not expressed in a novel environment during 50 generations of experimental evolution in Tetranychus urticae hybrids biorxiv.org 2026-07-17 Hybridization, the interbreeding between species or genetically distinct populations, can lead to deleterious fitness consequences, but simultaneously
A high aneuploidy supply rate underlies parallel evolution of fluconazole resistance in Saccharomyces cerevisiae biorxiv.org 2026-07-17 Copy number variants (CNVs) of ERG11 play a major role in acquisition of resistance to the commonly used azole family of antifungal drugs in many path
Chromosome-scale genome assembly of Cycas revoluta provides insights into cycad diversification and species diversity biorxiv.org 2026-07-17 Cycads are an ancient group of seed plants. Despite their ancient origin, many extant cycad genera exhibit high species diversity.
Structural elements required for the efficient loading and activation of HELB on RPA-coated single-stranded DNA biorxiv.org 2026-07-17 HELB is a human helicase involved in DNA repair and replication that interacts physically with the single-stranded DNA binding protein RPA.
A Robust and Generalizable Low-Input Spatial Proteomics Workflow Enabling Deep Proteome Coverage biorxiv.org 2026-07-17 Spatial proteomics has rapidly emerged as a powerful approach for deciphering the molecular architecture of complex tissues, offering critical insight
Multivalent Tau-Fyn interactions cooperatively arrest postsynaptic density condensate dynamics biorxiv.org 2026-07-17 Tau-Fyn signaling at postsynaptic sites is implicated in synaptic dysfunction and neuronal hyperexcitability in Alzheimer's disease and related tauopa
Integrated Interactomics Reveals Novel Protein Associations: The FOXA1-PBX1 Complex as a Case Study biorxiv.org 2026-07-17 Protein-protein interactions (PPIs) are fundamental to cellular signaling networks, yet many remain undetected due to technical limitations of individ
Genetic encoding of 3-cyano-tyrosine and its use in controlling the chromophore isomeric state of the fluorescent protein mKate biorxiv.org 2026-07-17 Switchable beta barrel-type fluorescent proteins are essential genetically encoded probes for super-resolution imaging.
Multi-Omics Characterization of Plasma and Urine Extracellular Vesicles Identifies Non-Invasive Biomarkers for IgA Nephropathy biorxiv.org 2026-07-17 Abstract Background IgA nephropathy (IgAN) is increasingly recognized as a systemic immune-mediated disease characterized by aberrant IgA1 glycosylati
Identification of type III polyketide synthases from Ginger for dehydrogingerdione and curcumin biosynthesis by engineered Escherichia coli biorxiv.org 2026-07-17 Many valuable plant metabolites are synthesized by type III polyketide synthases (PKS) that have become targets for the engineering of microbial produ
Fungal microbial enrichment method enables fungal metagenomics directly from human clinical samples biorxiv.org 2026-07-17 Fungi play important roles in health and disease, but current methods such as culture, PCR, and amplicon sequencing cannot provide genome-level charac
A deployable microfluidic platform for parallel and longitudinal hyperpolarised magnetic resonance metabolic phenotyping biorxiv.org 2026-07-17 Hyperpolarised magnetic resonance (MR) enables real-time measurement of metabolic flux in living systems but remains difficult to deploy for cell-base
Distributed resonant coupling enables high efficiency power transfer to mm-scale bioelectronics biorxiv.org 2026-07-17 Miniaturized implantable bioelectronics offer breakthrough potential in disease treatment, biomarker monitoring, and physiological sensing.
PFM: perturbed flow matching for structure-based drug design biorxiv.org 2026-07-17 Generating 3D molecules that bind to specific protein targets via generative models has shown great promise in structure-based drug design.