Integrating Genome-Wide Association Analysis, Functional Annotation and Regulatory Genomics for the Prioritization of Candidate Variants Associated with Grain Yield in Upland Rice biorxiv.org 2026-07-16 Grain yield is a highly complex quantitative trait in rice, resulting from the interaction of multiple genetic, physiological and environmental factor
A proteomic and phosphoproteomic comparison of mouse spermatogonial stem cells and progenitor spermatogonia biorxiv.org 2026-07-16 In this manuscript, we used an Id4-eGfp mouse line to produce the first proteomic and phosphoproteomic database for mouse spermatogonial stem cells (S
Bacterial-driven development is mediated by Calcium-Dependent Intrinsic Apoptosis in the Squid-Vibrio Symbiosis biorxiv.org 2026-07-16 The presence of beneficial microbes serves as a post-embryonic developmental cue in a wide array of metazoan species.
Validation of a high throughput fluorescent Capillary Electrophoresis Sodium Dodecyl Sulfate method for monoclonal antibody size heterogeneity assessment biorxiv.org 2026-07-16 Fluorescent capillary gel electrophoresis (CGE) with sodium dodecyl sulfate (CE SDS) provides a powerful, high sensitivity alternative to ultraviolet
The genetic architecture of human programmed stop codon readthrough biorxiv.org 2026-07-16 Programmed translational readthrough produces C-terminally extended protein isoforms via decoding of stop codons by near-cognate tRNAs.
Taxonomic Resolution of 16S rRNA, FastANI, Mash, and FastAAI across 30,495 Prokaryotic Type-Strain Genomes biorxiv.org 2026-07-16 Prokaryotic taxonomy now relies on both marker-gene and genome-wide sequence comparisons, but these methods differ in taxonomic range, scalability, an
FUSED: A Functional Representation for Joint Structural and Elemental Analysis of Protein Ligand Binding Sites biorxiv.org 2026-07-16 Ligand binding site representations are central to the analysis of protein-ligand interactions, with applications in functional characterization, bind
Magnetosensitivity of amphibian morphological pigmentation is light- and eye-dependent and consistent with the radical pair mechanism biorxiv.org 2026-07-16 Weak magnetic fields influence a wide range of biological processes, yet the underlying mechanisms are poorly understood.
A multiscale cytoskeletal network model for shear rheological property and its evolutionary mechanism biorxiv.org 2026-07-16 The cytoskeleton is a dynamic biopolymer network whose shear rheological properties are crucial for cellular physiology and pathology.
CHARMM-GUI Covalent Ligand Docker as a Web-based Molecular Docking Platform for Covalent Ligands biorxiv.org 2026-07-16 Covalent inhibitor research is an emerging topic in drug discovery due to its superior performance in specificity and inhibition effects.
A principal-stress rule for cell division in epithelia biorxiv.org 2026-07-16 Dense active materials, from cellular tissues to jammed and glassy systems, must continuously relieve internal mechanical stress to remain structurall
On the Polymorph-Selection Determinants of α-Synuclein Amyloid Fibrils Studied at Atomic Resolution biorxiv.org 2026-07-16 Alpha-synuclein is an intensely studied intrinsically disordered protein whose aggregation into amyloid fibrils is connected to the progression of sev
FENNEC: photon-level deep learning for classifying bursts in diffusion-based single-molecule FRET biorxiv.org 2026-07-16 Single-molecule Forster resonance energy transfer (smFRET) reports on biomolecular conformational dynamics by measuring distance changes between donor
The folding, dimerization and allosteric landscapes of the ALS protein SOD1: a comprehensive mutational atlas biorxiv.org 2026-07-16 Mutations in superoxide dismutase 1 (SOD1) can disturb monomer folding and dimerization, ultimately leading to the development of amyotrophic lateral
A Charge-Encoded Rheostat Permits Helix Nucleation but Limits Propagation in Skp1 biorxiv.org 2026-07-16 Molecular recognition by intrinsically disordered regions (IDRs) is widely thought to involve coupled folding and binding, yet the sequence features t
Ultrafast X-Rays Capture Retinal Traversing Conical Intersection in Rhodopsin biorxiv.org 2026-07-16 G-protein-coupled receptors of the Rhodopsin family are crucial medicinal targets, transmitting signals across biomembranes.
How long is the brain perfusable after global ischemia? A systematic review biorxiv.org 2026-07-16 Background: Global cerebral ischemia initiates a cascade of pathophysiological changes that progressively impair subsequent perfusion of brain tissue.
Locomotor adaptation can persistently reorganize stride-to-stride regulation of centre of mass error dynamics biorxiv.org 2026-07-16 Locomotor learning in novel environments relies on a gradual alteration of motor output to achieve a desired state.
Distinct and shared neural resources between processing of dynamic physical objects and spatial working memory biorxiv.org 2026-07-16 In human brains, portions of the frontoparietal cortex respond when people reason about the physical world (e.g.
Diaphragmatic EMG Uncovers Left-Right Diaphragmatic Imbalance After Ischemic Stroke with Implications for Motor Recovery biorxiv.org 2026-07-16 Background: Stroke-associated respiratory dysfunction has been increasingly recognized, yet whether diaphragmatic impairment after stroke involves lat
Discovering Heterogeneous Neurodegenerative Disease Patterns From MRI Data for Improved Prediction biorxiv.org 2026-07-16 Neurodegenerative diseases exhibit substantial heterogeneity, complicating both diagnosis and prognosis.
Glycogen-Dependent Metabolic Reprogramming Regulates Microglial Activation and Dysfunction in Neurodegenerative Disease biorxiv.org 2026-07-16 Microglia are central regulators of neuroinflammation in Alzheimers disease (AD), yet how metabolic states modulate function remains unclear.
Dissociable Neural Responses to Conditioned Social Threats are Modulated by Spatial Proximity in PTSD and MDD biorxiv.org 2026-07-16 The brain's response to potential threats is shaped by the egocentric spatiotemporal distance to the threat.
A claustro-cortical loop times state transitions for flexible behavior biorxiv.org 2026-07-16 Metastable dynamics, in which neural activity moves between transiently stable patterns, have been proposed to underlie the real-time coordination on
Distinct Computational and Temporal Mechanisms Underlie the Joint Effects of Motivation and Working Memory on Perceptual Sensitivity biorxiv.org 2026-07-16 Human perception is continuously shaped by internal cognitive states, yet how motivation and working memory jointly influence perceptual sensitivity r
Convergent Inhibitory Cortical Circuit Disruption Drives Genetically Distinct Absence Seizures biorxiv.org 2026-07-16 Absence seizures, the most common childhood epilepsy, are characterized by brief involuntary lapses in consciousness and 3-Hz spike-wave EEG discharge
Bacterial histone-like proteins released during antibiotic treatment mediate vascular injury in meningococcal sepsis. biorxiv.org 2026-07-16 Vascular injury and coagulopathy are key drivers of mortality in bacterial sepsis.
Essential Molecular Variables of liverworts in biological soil crusts biorxiv.org 2026-07-16 (1) In plant ecology, functional traits are widely used to predict plant performance in ecosystems.
Combinatorial MAPK states drive opposing gene programmes: a reanalysis of MAP3K-driven transcriptional responses in MCF10A cells biorxiv.org 2026-07-16 Background.
Open Digital Bioassays Enabled by Aqueous Two-Phase Microreactor Arrays biorxiv.org 2026-07-16 Digital bioassays enable precise single-molecule quantification but are difficult to adapt to point-of-care testing (POCT) because conventional protoc