One Health genomic surveillance reveals structured urban rabies transmission and major surveillance gaps biorxiv.org 2026-07-10 Persistent local foci remain a barrier to eliminating dog-mediated rabies.
Joint analysis of multiply perturbed cells improves statistical power and cost efficiency in Perturb-seq biorxiv.org 2026-07-11 Perturb-seq measures transcriptomic responses to genetic perturbations at scale, but conventional designs that enrich for one guide RNA per cell remai
A Genetic Atlas of Direct and Inverse Neuropsychiatric-Cancer Comorbidity biorxiv.org 2026-07-11 Direct and inverse comorbidities between neuropsychiatric disorders and cancer are increasingly recognised as important features of the nervous system
Spatial mitochondrial lineage tracing uncovers a premetastatic niche and microenvironment programmed fate switching in osteosarcoma biorxiv.org 2026-07-11 Osteosarcoma progression involves complex spatiotemporal dynamics, yet the lineage relationships underlying tumor cell fate decisions remain poorly un
Glycine molecule radical: Predicted properties and dipeptide formation biorxiv.org 2026-07-10 Numerous advances in quantum and computational chemistry over the last decades, as well as the development of computer science, allowed utilisation of
MARiO: predicting cancer variant pathogenicity by integrating in silico evaluation and patient-level mutational contexts biorxiv.org 2026-07-10 Comprehensive genomic profiling (CGP) supports precision medicine in cancer care, but accurate assessment of missense variant pathogenicity, especiall
Benchmarking AI-Driven PTIm-mAb Across Eleven FDA-Approved Bispecific Antibodies: A Cross-Tool Validation Study biorxiv.org 2026-07-10 Background.
Safeguarding open-weight genomic foundation models through weight locking biorxiv.org 2026-07-10 Background.
Interaction-finder: automated literature-based discovery of biological entity associations with quote-level provenance biorxiv.org 2026-07-10 Identifying interactions between biological entities is a cornerstone of molecular research, but assembling such lists from the literature is slow and
MAERM: Predicting Enzyme-Reaction Matching Relationships with a Mixed-Attention Model biorxiv.org 2026-07-10 Harnessing enzyme specificity requires a thorough understanding of enzyme promiscuity, which determines enzymes' catalytic scope; however, measuring t
Comparative Modelling of Actin-Tropomyosin Interfaces biorxiv.org 2026-07-10 Tropomyosins are coiled-coil dimers that polymerize head-to-tail along actin filaments.
Evaluating the cross-species transferability and scaling of sequence-to-function predictions in AlphaGenome biorxiv.org 2026-07-10 Deep learning models that predict molecular phenotypes directly from DNA sequence offer a powerful framework for interpreting genomic variation.
Improved 3D Radial Phyllotaxis Trajectories for Uniform Density Distribution of Readout Directions and Sequential Binning biorxiv.org 2026-07-10 Purpose: To develop 3D radial spiral phyllotaxis trajectories that provide a uniform density distribution of readout directions and support retrospec-
AtlasLens: Metadata-centric exploration and analysis of single-cell atlases biorxiv.org 2026-07-10 Motivation: The rapid expansion of single-cell RNA sequencing (scRNAseq) atlases has generated datasets comprising millions of cells annotated with in
Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems biorxiv.org 2026-07-11 Abstract Background: Calcineurin inhibitors (CNIs) are indispensable for transplantation immunosuppression, yet cyclosporine A (CsA) produces renal to
Fetal sex shapes placental inflammatory responses to extracellular mitochondrial DNA biorxiv.org 2026-07-11 Aberrant changes in circulating cell-free mitochondrial DNA (ccf-mtDNA) across gestation are associated with adverse pregnancy outcomes.
Hepatitis C Virus Remodels Lipid Droplets to Promote Mitochondrial Fatty Acid Accumulation and Metabolic Activation biorxiv.org 2026-07-10 Here, we investigated the temporal remodeling of LD-associated metabolic pathways during HCV JFH-1 infection of human hepatoma Huh7 cells.
AI-Driven Discovery and BSL-4 Validation of Cross-Filovirus Ebola-Marburg Inhibitors and their Synergistic Combinations biorxiv.org 2026-07-10 Filovirus outbreaks caused by Ebola virus (EBOV) and Marburg virus (MARV), pose severe global health threats characterized by high rates of fatal hemo
Paraspeckles translate microbial insult-induced inflammation into neurovascular remodeling by enhancing CYR61-FGF2 signaling via RBM14 sequestration biorxiv.org 2026-07-10 Objective: Systemic inflammation triggered by microbial insults can disrupt endothelial homeostasis, impair blood-brain and blood-retinal barriers, le
Evolutionary Dynamics of the Complete Chemosensory Repertoire in Kissing Bugs of the Genus Rhodnius: Divergent Odorant Receptors Contrast with Conserved Gene Families biorxiv.org 2026-07-10 Chemosensory systems play a central role in host detection, feeding behavior, and habitat selection in hematophagous insects.
Integrating Bottleneck Size into Selection Tests for Biological Diversity Data biorxiv.org 2026-07-10 Population bottlenecks profoundly shape genetic diversity, but distinguishing stochastic drift from selective pressure requires precise estimation and
AAV VP1 unique region (VP1u) determines GPR108 dependence for AAV transduction of human airway epithelium and its rescue by Doxorubicin biorxiv.org 2026-07-10 rAAV2.5T was identified through directed evolution of an AAV capsid library in polarized human airway epithelium (HAE) cultured at an air-liquid inter
Diverse and novel lanthanide-binding PQQ-dependent enzymes biorxiv.org 2026-07-10 First described pyrroloquinoline quinone-dependent (PQQ) eight-bladed {beta}-propeller proteins are calcium (Ca)-dependent, but many homologous bacter
A nitrite-responsive regulatory RNA locus sustains commensal resilience against nitrosative stress biorxiv.org 2026-07-10 Commensal microbes in the gastrointestinal tract are central to host health, yet they must adapt to frequent perturbations such as intestinal inflamma
Microcystin-Driven Control of the Carbon-Concentrating Mechanism Shapes CO2 Fixation Dynamics in Microcystis aeruginosa PCC 7806 biorxiv.org 2026-07-10 Bloom-forming cyanobacteria thrive in highly dynamic light environments, yet the mechanisms enabling rapid acclimation to fluctuating irradiance remai
Iron Metabolism and Adaptative Traits Associated with Virulence in Enterobacter cloacae Complex biorxiv.org 2026-07-10 Iron is an essential micronutrient that shapes host pathogen interactions during infection.
Chronic Disease Emergence in Coevolving Social Networks via Behavioral Feedback and Demographic Turnover biorxiv.org 2026-07-10 Chronic diseases emerge within social systems where individuals reorganize their ties, adapt their behaviors, and turn over through demographic proces
Transformer models of mutation risk at base-pair resolution identify non-coding hotspot cancer driver mutations biorxiv.org 2026-07-10 Recurrent somatic mutations reveal cancer drivers, but in whole genomes many non-coding hotspots are passengers generated by localized mutational proc
Concerted evolution and unorthodox recombination of human subtelomeres biorxiv.org 2026-07-10 Human subtelomeres contain duplicated sequence that is shared among the ends of non-homologous chromosomes and provides a substrate for ectopic exchan
An endogenous retrovirus insertion disrupting bovine ALKBH8 causes a failure-to-thrive syndrome with immunodeficiency associated with juvenile mortality in Brown Swiss cattle biorxiv.org 2026-07-10 The Brown Swiss (BS) cattle breed is one of the major Swiss dairy breeds.