ELDR-Glo, a biosensor for cell age and quiescence depth biorxiv.org 2026-07-10 Fluorescent reporters are powerful tools to reveal intercellular heterogeneity among proliferating cells.
Reduced LANCL1-AS1 in old human skeletal muscle diminishes mitochondrial activity, shortens mt-mRNA poly(A) tails, and suppresses myogenesis biorxiv.org 2026-07-10 Regeneration of skeletal muscle preserves muscle mass and function, which decline with age.
Biogenesis and antigen presentation properties of dendritic cell-derived apoptotic bodies biorxiv.org 2026-07-10 Dendritic cells (DCs) are an important type of antigen presentation cell that regulate immunity by initiating antigen-specific immunity and tolerance
METTL1 regulates glioma proliferation through internal m7G methylation of EPHA2 biorxiv.org 2026-07-10 BackgroundMethyltransferase-like 1 (METTL1) is highly expressed in organs like the pancreas but less so in the brain.
Endotome as a Source of Human Peri-Aortic Brown Adipocytes biorxiv.org 2026-07-10 Brown adipocytes (BAs) hold therapeutic promise for obesity and metabolic diseases.
TAOK3 inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancer biorxiv.org 2026-07-10 TAOK3 is a lesser-studied MAPK family serine/threonine kinase our group has shown to be targeted by HPV integration, suggesting a potential role in dr
Autonomous computational prioritisation of colorectal cancer vulnerabilities via multi-scale AI swarms biorxiv.org 2026-07-10 The acceleration of automated scientific discovery has been fundamentally bottlenecked by the epistemic gap between the semantic reasoning of large la
Kinome-wide CRISPR/Cas9-knockout screening reveals critical protein kinases in vasopressin V2-receptor signaling biorxiv.org 2026-07-10 Identification of signaling networks is an essential goal in systems biology.
Dynamic Histone Lysine Methylation and Demethylation in Wood Frog (Rana sylvatica) Liver During Anoxia biorxiv.org 2026-07-10 Anoxia is a major stress for most vertebrates and frequently accompanies harsh winter conditions, particularly in species that spend much of the seaso
The structure of the apo-PIWI HSP90 complex biorxiv.org 2026-07-10 PIWI proteins are members of the Argonaute family and together with piRNAs protect metazoan germlines from transposons.
Challenges in reconstituting the peroxiredoxin 2:STAT3 transient redox-relay complex in vitro biorxiv.org 2026-07-10 Peroxiredoxin 2 (Prdx2) mediates redox signaling by transferring oxidative equivalents to target proteins such as STAT3, a redox-sensitive transcripti
Insulin synthesis is sustained by Tent5 poly(A) polymerases biorxiv.org 2026-07-10 Insulin is an essential regulator of glucose homeostasis in vertebrates, and impairment of its synthesis or action leads to diabetes with severe healt
Cardiomyocytes possess an intrinsic catecholaminergic machinery that regulates cellular homeostasis and electrophysiological stability biorxiv.org 2026-07-10 BackgroundCatecholamines play a central role in cardiac performance, coordinating myocardial contractility, conduction, metabolism, and electrophysiol
Semi-automated reconstruction of glomerular architecture from 3D confocal microscopy data biorxiv.org 2026-07-10 Nephrons are the functional units of the kidney; within each nephron, the glomerulus is the initial site of selective filtration that allows removal o
Neuropeptide Y4 receptor activation delays autoimmune diabetes by reprogramming β-cell stress and immune tolerance biorxiv.org 2026-07-10 Type 1 diabetes (T1D) involves immune-mediated destruction of pancreatic {beta}-cells, yet current disease-modifying therapies mainly target immunity
TLR7 Signaling Regulates Embryonic Hematopoietic Stem Cell Development by Sensing microRNA-146a in Vertebrates biorxiv.org 2026-07-10 The specification of hematopoietic stem cells (HSCs) is tightly regulated by multiple transcription factors and signaling pathways.
Sulfoquinovosylacylpropanediol monotherapy suppresses canine hemangiosarcoma patient-derived xenograft models with vascular remodeling biorxiv.org 2026-07-10 Canine hemangiosarcoma (HSA) is an aggressive endothelial malignancy with limited therapeutic options, and its progression is closely associated with
Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity biorxiv.org 2026-07-10 Background/ObjectivesGlioblastoma is an aggressive primary brain tumor that develops within a chronically low-oxygen microenvironment, yet most precli
Peer-Led Leadership, Mentoring and Promotion: Conversations Among Female Academics from South Africa, Ghana and the United Kingdom biorxiv.org 2026-07-10 The focus was on leadership, mentoring and promotion.
The Drosophila FET orthologue Cabeza is an essential cofactor for ETV4-mediated activation of GGAA microsatellite neoenhancers biorxiv.org 2026-07-10 The conversion of transcriptionally silent GGAA microsatellites (GGAASats) into functional enhancers by FET::ETS oncogenic fusions is a hallmark of Ew
Deconvolving the spatiotemporal chromatin landscape through the cell cycle biorxiv.org 2026-07-10 Profiling genomic processes during the cell cycle is challenging because synchronized populations gradually lose synchrony as individual cells progres
The atypical RHO-GTPase RND3/RHOE interacts with FLRT3 to regulate cortical migration and folding biorxiv.org 2026-07-10 Cortical gyrification, characterized by the formation of sulcal fissures and gyral peaks, is a distinctive feature of large mammalian brains and is as
Integrative multiomics profiling of cortical brain organoids reveals a druggable alternative splicing program in schizophrenia biorxiv.org 2026-07-10 Clozapine (CLZ) is the only available pharmacological option for treatment resistant schizophrenia (TRS), but its use is limited due to adverse drug r
Parvalbumin and somatostatin interneurons support distinct computations during auditory scene analysis biorxiv.org 2026-07-10 Auditory scene analysis requires cortical circuits to preserve target-sound representations while suppressing interference from competing sound source
Neurophysiological Evidence for Reduced Use of Prior Sound Patterns to Shape Speech Processing in Autism biorxiv.org 2026-07-10 Reported perceptual differences in autism may arise from reduced use of prior context to shape incoming sensory input.
Learning the wiring rules of a mammalian cortical column biorxiv.org 2026-07-10 Characterization of neural circuits' architecture typically relies on measurable neuronal features such as morphology, molecular identity, and spatial
Human medial temporal lobe neurons link future reward coding with intertemporal choice and impulsivity biorxiv.org 2026-07-10 The ability to delay gratification emerges early in life and is linked to long-term health and economic success.
Protracted Maturation of Proactive and Reactive Systems Predicts Cognitive Stability and Psychopathology : A longitudinal multi-cohort study biorxiv.org 2026-07-10 Inhibitory control matures progressively from childhood to early adulthood, yet the neural mechanisms driving this development and their relevance to
Correlation analysis of changes in the expression of C1qtnf superfamily genes in the hypothalamus, thymus, and lungs against the background of chronic social stress during the development of Lewis lung adenocarcinoma in mice biorxiv.org 2026-07-09 It has been previously shown that chronic social defeat stress caused by paired agonistic interactions between male mice is accompanied by the develop
Abbapolin inhibitors of the PLK1 PBD as Prostate Cancer Therapeutics, in vivo activity and synergy with androgen therapy biorxiv.org 2026-07-09 Polo-like kinase 1 (PLK1), a key regulatory protein controlling entry into and passage through mitosis, has been targeted through its kinase domain (K